What type of Peyronie’s treatment should my husband try?

Dr. Herazy,

My husband has been struggling with accepting he has Peyronie’s disease.  The purchase of your book has really helped inform us about this disease. He is also a diabetic. What type of treatment should he try to help with his condition? He has not tried anything yet due to the fact of feeling like there is nothing that can be done or that will work. His case does not seem to be severe. We would appreciate any advice/support.
Thank you!

Your husband should start with the most aggressive therapy plan he is comfortable following so he will get the best results possible. If he is inclined to want to do everything possible to help himself, then perhaps he could consider using what is called the “Large (Best) Plan” for personal treatment. The “Medium (Better) Plan” is perhaps the most popular of the three plans. There is a “Small (Good) Plan” that is also well designed. These products and plans are found at Peyronie’s treatment products.   All plans can be modified, by subtracting or adding, to suit your personal Peyronie’s disease treatment philosophy.
Or, you can design your own therapy plan using the information found on this website. You do not have to use any of these model plans, they are only examples – but they make sense and they have helped hundreds of men improve their Peyronies plaque and reduce the bent penis of Peyronie’s disease.
For a starting point for treatment, go to Peyronie’s treatment help starts here.

However, there is a larger issue, isn’t there? If he has taken the word of people who have played with using vitamin E for their Peyronies, or dabbled with taking Neprinol, and found that their results were not good, then he is in trouble. So many people love to get on the Peyronie’s disease forums and write, “I tried PABA (or something else), and it did not work. Nothing works!” I know from many hundreds of cases I have dealt with each year since 2002, that when someone writes something like that they have not gone about their treatment in the correct way. Using a single therapy is not the way to get results with PD. Their lack of good results is not surprising.

We are not conducting formal research, nor is it possible to collect meaningful research data based on the way that I have no way to monitor how people are following their plans. What I can tell you is that I receive 10-12 phone calls and emails telling me of Peyronie’s progress and improvement, for every one phone call and email I receive saying nothing is happening. That is a good rate of success. When I learn what these men who say they are not progressing are actually doing, it is easy to understand their lack of progress.    

If your husband is waiting for some Peyronie’s treatment that comes with a guarantee, then he is in for a long wait. No PD treatment works all the time or works well in every case.

It could be that he is in a state of depression and denial about having Peyronie’s disease. If you think that might be the case, please suggest to him that he calls so I can speak to him. I will be happy to do what I can to help him.   TRH

Any suggestions for using a DMSO “wrap”?

Hi Dr.Herazy my question is about using "wraps" im only using DMSO/Vitamin E/Castor oil wrap, im just curious what is the best way to leave a cloth/wrap that a guy uses to keep it in place, i tried using duct tape to keep the cloth on my penis it works but the thing is i can't keep it in one place, kinda loose on my penis so i feel like my penis isn't getting the complete benefit if i were to find a tighter wrap or bandage somewhere at or store… because i can't keep the cloth from sliding off, so i would like to know is there something i can buy like at Walmart or something im thinking of a way to keep the cloth adhere to the penis skin so i'll know the wrap with the 2 oils are getting into the plaque online some websites say to use a rubber band to keep it in place but that frightens me, so what is the best way and a place i can find a wrap that can adhere too the skin so it isn't so loose wrapped around the penis. It's so frustrating trying to use a DMSO wrap but can't keep it in place… any suggestions for people going this route?


Stop what you are doing for two reasons:

  • What you are doing is potentially dangerous – by applying prolonged compression to the penis with rubber bands or duct tape you cannot help but cut off blood circulation, and this is a good way to develop Peyronie's disease.  One of the proposed mechanisms of developing PD is by micro-reduction of blood circulation, and this is what you are doing.  Just like we are warned to release a tourniquet for a minute every ten minutes, you do not want to cut off blood circulation for too long to any part of the body.  Many men develop PD from using a "cock ring."  Your method of holding the wrap in place could easily do the same thing to you.
  • How you are using DMSO does not make sense – DMSO works in just a few minutes and does need to held in place for hours.  DMSO is a great PD therapy, but it must be used correctly and safely.   When you buy DMSO form this website you will be given complete instructions how to use it properly and without harm to you.  There is absolutely no reason to leave a "wrap" in place for hours on end, because nothing happens under that wrap after a very short time.  Your DMSO does its maximum work in the 1st seven minutes or so after you apply it to the skin, and after that not much happens. Using DMSO is not like sunbathing, when the longer you do it the more will happen.   If you feel a sensation of warmth, it is only because you have your shaft wrapped in a cloth that is covered by plastic.    

It is really amazing what dangerous and upside down thinking I see on the Peyronie's disease forums from people who promote ideas without knowing  what they are doing.  I think you were given some bad information.    

You are apparently, for some reason you did not explain, using a modification of the Thacker's formula.  If you intended to use the Thacker formula you were given false information about that, also.

There is a better way to use DMSO, just go to the PDI website to read how it should be done.   

Are male enhancement pills effective in helping Peyronie’s diease?

I am using vitamin C, E, Scar-X, PABA, Fundamental Sulfur, Fibrozym, Nattokinase, Stimulin and Male Booster-X.  I have an hourglass curve at the base of my penis together with an upward bend. I am seeing some slight reduction in the deformity. My penis remains about an inch shorter than it was originally, Is there anything else I can do to regain the length. I tried the stretching exercises from your video with no result.  Are male enhancement pills effective?



There are many things to say about your email and how you are approaching your problem:

1. Listing your therapy products by name without telling me how many you are taking of each, and when you are taking them, is not helpful.  I need details of how you are using the therapy products you are taking.   I also need to know how long you have been using this plan.

2.  Stimulin and Male-X Booster are not intended to help Peyronie's disease.  I think you got the idea that sexual stimulant supplements can be used this way because many MDs prescribe Viagra for PD.  Viagra can be harmful to PD and even cause it; the sexual stimulants we suggest you use are mild enough that they will not harm you.   However, these two products will only increase sexual response (which is a good thing if you are having problems that way), but they do not help reduce the PD scar. 

3.  I am happy for you that you are seeing reduction of your deformity – congratulations.  But, that is not the way to go about monitoring your progress or determining if your therapy plan is working.  PD is all bout the Peyronie's scar.  Your deformity gets your attention and stresses you, and you want to get rid of your deformity, but it is the PD scar that is causing your deformity.  You must carefully monitor your scar to know how you are doing.  Your treatment plan is NOT determined by your deformity, but by the size, shape, density and surface features of your PD scar.  Please, you need to get "Peyronie's Disease Handbook" to learn how to do this; all of the important information about monitoring your scar is located in chapter 4 of that book. 

4. You have no way of knowing if the stretching exercise video did or did not help because you do not know the size, shape, density and surface qualities of your scar.  You are just guessing at this point if your stretching work was or was not helpful to you.  Besides, there is no way to isolate that one therapy did not help you while you are doing so many others.  All of your therapies work together to make changes in your overall condition.   You say your distortion is better, right?  How do you know the stretching exercises did not contribute to that progress?  Also, you need to tell me if you were able to feel the "deep dull ache" that is mentioned so often in the video while you were doing the penis stretches. 

5. Lastly, all your therapies are internal in nature.  This is a flaw of your plan.  You need to do some external therapies to round out your plan.  If you need help making that decision, let me know.  You cannot assist your recovery with a plan that is unbalanced between internal and external therapies.   

You cannot give me a few lines of vague information and expect me to help you.  Details please.    TRH   

Advice about penis spitting whitish yellow drops


I am having this problem and i am very conscious about my penis being disturbed. I have research a lot on your website and concluded that i am suffering from Peyronie's disease with slight left penile curvature without any constrictive ring or hourglass. 

My penis is spitting whitish yellow drops whether i am awake or sleeping and I am helpless to do anything.  I started throwing all my underpants and pajamas.   I used to masturbate a lot before 3 to 4 months, and used to grab my dick head to stop wasting the sperm, until one day it hurt me very bad.  But ignoring that day i slept  and after a couple of days i started feeling heavy pain that I used to hold my piss for a whole day or even 2 sometimes getting afraid of the pain.  Then gradually it decreased, and now again i am feeling pain with every piss.   My penis is curved slightly left and spitting drops very often.  I have postponed my wedding due to this, and really is very dishearted of the situation.

Please help me out.  I will always pray for you and your family in good or bad times.  A detailed and prompt answer would be highly appreciated

Best regards,  Umair


Greetings Umair,

Based on your description it is possible that you injured your urethra by your practice of masturbating but pressing on the head of the penis to prevent complete ejaculation.  I think it is not likely you have Peyronie's disease, even though you do have a penile curvature.

I strongly encourage you to go to your local medical doctor and explain your problem to him for prompt medical attention.  

Good luck to you.  TRH

Is there a treatment for my hypospadias?

i don't think i have this condition, but what is the matter with me is, i never was circumcised and i have a false opening. i urinated from beneath the head of the penis through a very tiny opening. after all these years, i can't even ejaculate  anymore. Is there a treatment for my problem?



As you are probably aware, you were born with a condition called hypospadias.  This is a birth defect that affects 400-500 births in which the opening of the urethra (pee hole) is not in the normal location.  When hypospadias occurs in boys, the opening is located on the underside of the penis, and when it occurs in girls the opening is into the vagina.  Surgery is most often elected to be performed before the child reaches puberty. 

There is no association of hypospadias and Peyronie's disease.  

I suggest you find the most competent and skilled surgeon specializing in genital reconstructive surgery for consultation.  

Good luck to you.  TRH  

What about using Kegel exercise as a Peyronie’s treatment?

2 very simple short questions do kegels exercises help peyronies i read it will or may because it's said to be a exercise that women used but it can be used in men and online says it can force more blood into the penis and help with the healing process. The other i have on my mind is i read W What does it mean to "Break Up Scar Tissue" I was reading about castor oil and they said it "breaks up" internal/external scar tissue and breaks them up? Is it different than "reducing" Could you clear up this definition? Thanks, and hope this wasn't too much to ask, but i just didn't want to forget the other question so i just put them both here in one, thanks again Dr. Herazy.


Yes, spend a of of time in our video. "Massage and Exercise" for Peyronie's disease to give you specific measures to assure you do Kegel exercises correctly for PD.   I have advocated Kegels for PD for many years, and used them as part of the Peyronie's disease treatment protocol when I got over it. 

You will have ask those people who use these terms – breaking up and reducing scar tissue – what they mean when they use them.  To me it sounds like careless use of words.   TRH

What are the chances my Peyronies will stabalize soon?

i am a healthy 50 yr old who has been diagnosed with Peyronie's disease about 14 months ago.  I've had a dent about 1 inch from the base approx.2 inches long during erection.  I thought it was stabilizing but seems to be getting slightly worse, moving towards the head.  I now think I'm starting to get some ED.  No treatment except vitamin E.  Starting to stress,what are your suggestions on treatment?   What are the chances this will stabilize soon?  Should i expect this to get worse?  Are the ED drugs (Viagra) a good idea to use?


You are asking several questions, most of which are answered many places within the PDI website.  I suggest that if you wish to learn more about PD you spend a little time reading what is here for you.  I will go through the questions and points you raise in order.

What looks like movement of the indentations is more likely the result of changes in the internal scar tissue, causing different patterns of pull on the tunica albuginea and layers of fascia within the shaft.  There is a wide variation of development of Peyronies, so be aware that your particular situation might be different from others you read about.  for many men these small but accumulative changes of the PD plaque or scar causes deformity changes over a period of many years.

There are two probable ways you could be experiencing ED at this point:  Physical – from the growth or contraction the PD scar material causing the internal valves of the veins of the shaft to remain open, thus preventing development of internal hydraulic pressure that creates an erection.  Sometimes this is a widespread problem affecting the entire shaft, and sometimes a local problem causing dents or bottleneck deformities.  Emotional – you are, as most men feel, angry, confused, scared, and/or embarrassed about what is happening to you.  The emotions have a great impact on the development of the erect state.

Using vitamin E by itself is almost no treatment   Vitamin E as a Peyronie's treatment is a great therapy, very essential, but it must be combined with other therapies to get the right kind of tissue response you are looking for.  

Treatment is the most thoroughly discussed subject on this website.  See "Introduction to Alternative Medicine treatment of Peyronie's Disease," and "Guide for Peyronie's Disease Treatment," and many others.

The PDE-5 category of drugs (Viagra, Levitra, and Cialis) can cause problems due to excessive erection development, resulting in over-inflation and possible tearing of internal tissues of the shaft.   See "Peyronie's Disease Plaque, Viagra, Cialis, Levitra and Blood Supply"  and  "Peyronie's Disease Treatment and Viagra, Levitra and Cialis" and many others.

Far better to learn about Alternative Medicine treatment of Peyronie's disease, take control of your situation, stop feeling so helpless and reduce your stressful state.  If you have specific questions about treatment please let me know.     TRH   

Is it really possible that Peyronie’s disease completely disappears?


Is it really possible that Peyronie's disease actually completely disappears?

One often-quoted study says that 13% of cases improve spontaneously after one year. This, however, includes very small curvature or plaque reduction. However, I have not heard of one single reliable and medically documented story of complete remission. It seems that even if some treatments appear to be effective in reducing or even dissolving the plaque, the tunica can never regain its original elasticity.

Can you give us your thoughts about this please.

Best regards,



Greetings Leo, 

Thank you for the excellent question.

How often, and to what degree, Peyronie's disease spontaneously recovers is such an interesting and important PD topic that I wrote,  "Spontaneous Remission and Natural Cure of Peyronie's Disease."    You might consider reading this also for additional ideas.

Anyone who has looked for help with Peyronie's disease knows why it has been called the bastard-child of medical practice.  No one should be surprised it has never been the subject of investigation to determine the frequency or degree of spontaneous recovery or natural healing.  I could not find any information about what criteria is used to determine a complete response to treatment or a spontaneous remission of Peyronie's disease.  For example, when all outward signs of cancer disappear after treatment, this is called a "complete remission" or a "complete response."   These terms do not necessarily suggest the cancer has been cured.  It only means the cancer cannot be detected in a way that it was previously used to identify it.  If after treatment the cancer is still present but in a reduced capacity to incapacitate the patient or of a reduced size, it is called a "partial remission."  In regard to Peyronie's disease these concepts might also apply, but this has not been worked out clinically for PD.  For this reason, the words we use (remission, recovery, response, cure, improvement, complete, partial) are subject to controversy because they have not been defined in relation to Peyronie's disease.  

Thus, there is room for interpretation when you ask if Peyronie's disease ever "completely disappears."   A consensus would have to determine if a practical (functional) or anatomical (structural) definition of recovery was to be used for Peyronie's disease.  Previously I have written, "the average man would not care at all that he had Peyronie's disease if it did not cause a penile distortion that denies him from having sexual intercourse.  If the Peyronie's lump did not interrupt sex activity, the problem would be essentially ignored." 

While i understand the thought and motive behind asking about a study of spontaneous remission of Peyronie's disease, I believe it is unlikely for the pharmaceutical or medical industries to actually spend money to research if this problem goes away on its own.  Their focus is far more likely to be directed toward drug creation or surgical advancements.  In preparation for writing this reply I Googled "spontaneous remission cancer" and "spontaneous recovery flu" and could not find any medical studies for those searches.  That this information is not available should not be interpreted that these things do not happen, but only that no one yet has taken the time, effort and money or has a vested interest to study these topics.   

For a majority of men, from a practical or functional standpoint, restoring sexual function would define "complete recovery" if this occurred as a result of direct treatment, or "spontaneous remission" if this occurred without treatment, regardless if the Peyronie's plaque persisted or the tunica albuginea was less elastic.  To underscore this prevailing and practical attitude that men take about their Peyronie's condition, I have communicated with many men who have told be that they like having Peyronie's disease because their particular direction and degree of penile curvature increased the sexual pleasure of their partner and thus they saw themselves as better lovers. Their interest in correcting their Peyronie's disease was equally practical and sexually motivated:  they were concerned that if the curvature worsened, they would not be able to engage in intercourse.  Conversely, from a clinical or anatomical standpoint, restoring previous physical normalcy (external appearance of the shaft, elimination of the internal fibrous plaque, complete elasticity of the tunica albuginea), would define "complete recovery" if this occurred as a result of direct treatment, or "spontaneous remission" if this occurred without treatment.  Without these terms being defined it is difficult to communicate accurately.

Yes, I am aware of that study reporting 13% of cases improve spontaneously; others reports suggest up to 50% of Peyronie's disease cases simply go away without treatment.  This variation in numbers is probably due to a different set of criteria for determining what degree of improvement constitutes a real improvement  or recovery; this is discussed in the 3rd paragraph. Given the nature of the problem It is easy to understand why there is still controversy and revision (usually upward) of the reported rate of occurrence of PD in the general population, to say nothing of the rate of spontaneous remission for the problem. 

When I developed Peyronie's disease I struggled frantically looking for a way out of the Peyronie's nightmare.  After reading reports of 20-50% spontaneous recovery from PD my thoughts turned in a more positive and productive direction.  The pivotal insight that occurred to me was:  "If 50% of men heal their own PD, then the body has a cure – even if the MDs do not.   All I have to do is increase my immune response to this PD scar in whatever way makes sense to me, and I believe I might be able to heal my problem like those lucky men who spontaneously correct their own problem.  Now I am in control."  Before that I held the common negative and hopeless victim mentality displayed on many of the Peyronie's forums. This little bit of information so encouraged me and uplifted my thinking, that I eventually developed the treatment protocol that enabled my body to heal my PD problem.  This same protocol (now improved in several significant ways) has since been used many hundreds of times by men who learned about it on this PDI website.

From my experience in working with men since 2002 I have used the informal, uncommitted, and long-distance format of the internet, emails and telephone calls.  Since I am not conducting formal research, I have no way to control, monitor or verify how anyone is conducting his PD therapy plan.  Men do what they want to do.  I can only offer suggestions and hope my message gets through.  Not only does everyone seem to create a slightly different therapy plan, but each man goes about using his plan in a different way.  The non-uniform and irregular application of the ideas you see on the PDI website makes it difficult to evaluate effectiveness or degree of improvement achieved.   Not only that, men are notoriously bad communicators about this aspect of their private life.  Once Peyronie's disease is eliminated from a man's life he quickly disengages from the problem and happily returns to his previous life, rarely contacting anyone about his success.  They gladly try to forget about the condition that so humiliated them and nearly ruined their lives.  Men are reluctant to discuss or report on the stigma of diminished size, erectile dysfunction and disfigurement associated with Peyronie's disease.  For these reasons the number of men who experience spontaneous improvement of their PD will always be much more speculative than even the number of men who have PD, which is wracked by speculation for the same reasons.      

You are correct, there are no formal medical studies of complete Peyronie's remission.   But what of those published medical statistics reporting 13-50% of cases that get well without treatment or outside intervention.  Is that not more than the medical acknowledgment or the single story of complete remission you asked for?  Further, what of the hundreds of urologists and family doctors each day around the world who advise their newly diagnosed Peyronie's patients to "come back in six months to see it it goes away"?  Aren't each of these MDs implicitly saying that from their experience they see a sufficient percent of PD cases clear up on their own, thus justifying the standard wait-and-see strategy they all use?  "Wait-and-see-back-in-6-months" is part of the standard medical protocol and must exist for some reason; do you think that spontaneous remissions happen often enough to build a treatment protocol around it?  I do.

I offer a simple speculation about the condition of the tunica albuginea after favorable Alternative Medicine treatment, because I do not know.  The body eliminates to the best of its ability what it does not need.   I have a scar on my knee from a childhood injury.  Over the years it has slowly faded and now is barely visible.  I assume that if there is no useful purpose for the PD scar within the tunica albuginea, the body will pick up the collagen fibers over time.  This might not be a fast process like the body removing the cells of inflammation, but it should at least in theory happen if only because the body is designed to eliminate foreign matter.  Along that line of thought, I am a retired chiropractor with a highly refined sense of touch developed over 42 years of practice.  When I report that I cannot find any evidence of my previous gang of PD scars, you can believe that they are either gone or so dramatically diminished in size.  Of course, this is ultimately speculation because surgery would be required to verify the actual state of my tunica.       

Lastly, it is difficult to know how to label my particular improvement of Peyronie's disease or the experiences of those men with whom I have worked.  They no longer come to the PDI site for treatment information because they are apparently satisfied with their previous Peyronie's problem after following their version of PDI therapy protocol.  I do not know if I can say my body eliminated or cured my Peyronie's disease, or not. I do not know if I can say I had a "complete remission" or a "partial remission" because those terms have not been defined clinically. 

All I know for a fact is that back in 2002 when I was at my worst, I could easily describe 4-5 different plaque primarily on the left and dorsal aspect of the shaft.  My primary distortion was a combination 35 degree curve to the left, a ten degree curve upward, with a counterclockwise rotation.  I say primary distortion because twice while I had this combination curve and twist, it was replaced for a few weeks by a severe bottle-neck deformity that made me sick to look at.   After following an aggressive and faithful PD therapy plan that I devised over many months, all of that went away.  I was able to monitor the slow and gradual reduction of the size, shape, density and surface features of each of those 4-5 plaque.  As I observed them slowly fragment and disappear, my distortions disappeared and my lost length and girth returned.  Today I cannot find any PD plaque and my shaft is straight.   I have worked with many men who have reported various stories along that same basic outlineOf course, some men respond better to Alternative Medicine therapy than others; not all respond well, and some do not get any improvement at all.  When I learn of men who are not making improvement I can usually trace it back to a small and non-aggressive application of the PDI therapy concepts that is revealed by meager and irregular purchase of therapies. Conversely, those men who report better results ask more questions, follow a more faithful and aggressive plan of action, and overall seem to be more focused and serious about their eventual recovery.       

Back to your original question, "Is it really possible that Peyronie's disease actually completely disappears?"   By that question I take it that you mean, "Is it possible that the tunica albuginea returns to a completely normal state after what you call a self-repair, self-healing or spontaneous remission?"  To that question l answer that I do not know.  I must assume that in order for my curvature pattern to improve, for my scars to be undetectable, for my lost length and girth to have been returned, that some favorable and demonstrable tissue change must have occurred within substance of my tunica.  This in turn should have caused the tunica to become more elastic than when it supported the nasty Peyronie's plaque.  Speculation, for sure, but logical.

For me, and I believe for the men who come to the PDI website looking for some straight information about what they can do to help themselves get well, I wish to say we do not care if the tunica albuginea completely returns to normal or not.   I am satisfied when a man tells me he cannot find his PD scar any longer; that he can have intercourse for the first time in many years; or that his penis is now straight.  At this time I am more interested in learning how to more effectively help the men who have Peyronie's disease so they can more quickly and efficiently eliminate their problem, than I am in splitting hairs while defining the words cure, healing, recovery and remission.

Again, thanks for the great question that gave me the stimulus to put a few thoughts on the internet that were not there previously.

Good luck to you and I trust that you are successful in dealing with whatever prompted your interest in this subject.  If you have interest in learning about Alternative Medicine Peyronie's disease treatment, please let me know.    TRH

What would you suggest I do to treat my Peyronies at this point?


I am the same man who is 73 years old now. who developed PD when I was 57. You responded to my recent question if there is anything I can do for myself or if after 16 years of having PD the time for treatment has passed.

I took Potaba (24 tabs a day for 2 years) when I was first got my PD.  What would you suggest I do at this point?  If you need more information, please contact me at the above email address.

Thanks, Jim Young


Greetings Jim,

First, please reread a part of the response I gave you yesterday.  I have already given you that exact information what you should do next when I wrote:

I think the healthiest and fairest way for you to approach your decision if you should
attempt treatment is to first learn what is involved in the Alternative Medicine approach
to recovery from Peyronie’s disease.  Then decide what is a reasonable length of time you
should be willing to devote to an aggressive and faithful program of care; maybe 4-6
months.   If it all makes sense to you, then begin care with the attitude that you will do
your very best.  

            “A good place to begin learning about this unique PD treatment is start Peyronie’s treatment.
Let me know if I can assist you in any way.”

I trust you went to that link and read carefully everything that is there for you.

Already I have told you what I think you should do:  read and learn about how this PDI method of Peyronie’s treatment works, then decide if it makes sense to you and if you can make the commitment to do it well. This is a fairly straightforward answer that should have been enough to get you going in the right direction.

But, I believe I understand your problem knowing what to do next. Your follow-up question, a common one, is basically asking me to take over for you to decide what you should do.  I cannot do that.  You are asking me to be your doctor, and I cannot do that from a 1,000 miles away without having examined you.  You are not my patient.  Actually, I would be a fool to make that kind of decision for you under these circumstances, and you would be a fool to listen to me. 

Almost everyone who first comes to the PDI website is in a common frame of mind in which you feel hesitant to take more control in the decision making process about your physical condition.  In this modern era in advanced countries a patient goes to the doctor, gives answers to a few questions and the doctor tells the patient what to do.  The patient often is given very little time and very little information about the problem or its treatment.  This is different.  In this situation I try to help you learn how to do this process of increasing the ability of your immune system to eliminate the PD scar, and you making all important decisions.

Sixteen years ago you learned what happened when you received the standard medical treatment for Peyronie’s disease.  The doctor decided you should take POTABA for two years –  that probably caused a lot of abdominal pain and digestive problems –  and nothing happened.  I will assume the doctor did not tell you much about your problem or treatment, and they were all rather fast office calls. You just did what you were told and that was about it.  This is different.  You have to be in control because I cannot.  You learn as much as you can about the process of using Alternative Medicine for your Peyronies problem.  When you run into a problem or have a question, you can return to the PDI website to get an answer.

As a further suggestion, for you to accept or not accept, if you are still having a difficult time deciding on how to get started, you might consider looking at the three model Peyronie’s treatment plans at the top of store front.  These are examples of what a good treatment plan looks like.  They are balanced and they fit into different price ranges.  Each of them can be modified by adding or subtracting the ingredients if you want to do that.  Your decision which you should use, if any. 

You will be pleasantly surprised, if you decide to use Alternative Medicine to assist your healing process, how much detailed educational information is included with each order PDI sends to you.  Written instructions are included with each order, providing information about the correct use of whatever you purchase from PDI and Natural Health Education LLC.   We attempt to provide all the information you need to make a good decision for yourself.        TRH

Do you have any natural Peyronie’s treatment to replace Flomax?

I am using your program of PDI.I am using flomax for prostate enlargement. Do you have any natural treatment to replace the flomax which destroyed my sex life.I will send any fees in advance. I am grateful for your help. Thank you Sami Shenouda

Greetings Sami,

Flomax is well known for its long list of unpleasant side effects.  Many men decide these side effects are worse than the symptoms of prostate enlargement.   You should talk to your doctor about the side effects of Flomax and discuss alternatives with him before changing your prescription drug intake. 

PDI does not have any natural Peyronie's treatment that would take the place of Flomax.

Because Peyronie's disease commonly occurs in men who are in the same age group in which BPH (benign prostate hypertrophy) occurs, I am often asked about working with BPH at the same time as PD.  For this reason PDI lists two very good herbal products, BioProstate and Prostate Supreme.  I have taken Prostate Supreme daily for many years. You can find them by going to the PDI store front; look for the button to get there in the upper right corner of the Peyronie's Disease Institute website. 

Please talk to your doctor before making any change with your prescription drugs.   TRH

Can I treat Peyronie’s disease after 16 years?

I have had PD since I was 57. I am now 73. Is there anything I can do at this point or has the time for treatment passed?


Yes, there is a lot you can do to treat Peyronie's disease even after this long, and this might make you feel good about yourself for the first time in a long while.

From my experience in working with men who have Peyronie's disease, most stop looking for information and help after just a year or two.  These men are defeated by the negativity they encounter on most Peyronie's forums.  The great majority of men who contact PDI for assistance have had their problem for less than five years.  Occasionally someone will contact me who has had PD for 10 years.  The longest standing case I have worked with previously was 12 years old.  Your 16 year old case of PD puts you in a special category.

While working with these men whose problem is older than average, I have always been impressed with the ability of the Peyronie's plaque or scar to still respond favorably.   As with those whose PD is still in the common five-year range, the response to Alternative Medicine treatment still seems to be in direct proportion to the aggressiveness and faithfulness of care provided. 

There is no way for me to predict or anticipate how anyone will respond to non-drug and non-surgical Peyronie's treatment.  I think the healthiest and fairest way for you to approach your decision if you should attempt treatment is to first learn what is involved in the Alternative Medicine approach to recovery from Peyronie's disease.  Then decide what is a reasonable length of time you should be willing to devote to an aggressive and faithful program of care; maybe 4-6 months.  If it all makes sense to you, then begin care with the attitude that you will do your very best.  

After so long living with this lousy problem, I commend you for not being beat down by all the negativity and hopelessness that surrounds Peyronie's disease. 

A good place to begin learning about this unique PD treatment is from the home page of the Peyronie's Disease Institute website.   Let me know if I can assist you in any way.  TRH

Is it possible for the Peyronie’s scar to be that small?


Please allow me to explain what's going on with me and advise on if I should proceed with treatment.

I've been having painful erections for 6 months now. It was an immediate progression and the pain has not subsided at all. It begins as i'm getting erect and the pain is quite substantial for the first few minutes after which it subsides quite a bit. There is additional pain when I squeeze/flex it…like you would if you tried to stop peeing midstream. This leads me to believe that it's something with the blood stream. The range of motion is extremely limited and is very painful whenever it's moved too much. I'm now at the point where i'm not getting as hard as I used too and part of it is a mental block because I know it's going to hurt. I haven't been able to achieve a full hard erection on my own for a couple months now.

I've gone to my general practitioner and a urologist and left without a resolution. I've searched tirelessly for an answer and peyronie's is the only thing that even remotely fits my symptoms. I've been checked for STD's, did a urine and blood sample, and everything checked out. My hesitancy with the diagnosis is I have no deformity with my penis and I'm unsure of any plaque buildup. There is a very small hardness in the center of my penis when flaccid that is a little painful when I press it. I would relate it to the size of the tip of a ballpoint pen. But it's not rock hard because it still feels somewhat squeezeable. Is it possible for the Peyronie's scar to be that small?

Could I be in the beginning stages and still feel this much pain? Is it safe for me to treat myself as if I have it to see if works? I keep reading about where this could lead and it's quite scary. My experience with traditional doctors has been very frustrating and expensive. The urologist didn't even consider peyronie's until i mentioned it but both doctors checked for it and neither felt any buildup. He said to take some vitamin E and that should fix it. I've been taking an extensive amount for 2 months now and nothing has changed.

'm 32 years old and in great health with an active sex life. I'm extremely concerned with these issues and i feel completely lost in finding a solution…please help.



Your story creates a picture of some poor care. 

First some basics about a few statements or observations made about Peyronie's disease in general and your situation in particular.  I will just respond back to what you have mentioned:

  1. Peyronie's symptoms can be rather variable from one man to the next.  You are having more pain, and more consistent pain, than most men experience with PD, but that does not mean it is not PD.   Some men have no pain with their PD condition.  
  2. Not having the advantage of having examined you, I can only speculate about the source of your pain.  My educated guess is that it is not coming from a blood vessel but from the PD scar pressing on the tunica albuginea and another layer of penile tissue called Buck's fascia which is rick in pain fibers.  If you had constant pain, or if your pain coincided with your heart beat I would then consider it could be related to a blood vessel.  Both of these tissues I mentioned could be irritated and stimulated enough to generate pain when being squeezed.
  3. You say you left two medical offices without resolution, meaning they did not come up with the diagnosis of PD.  What did they speculate could be your problem.   Did they just leave you hanging with no ideas, no follow up?  So it is you who has come to this possible conclusion of Peyronie's disease on your own after doing some reading on the internet.  The fact that you mention your blood work was negative makes a case for not having a serious or life threatening problem going on, my speculation is that this supports PD as a possible diagnosis.  Personally, I have to suggest that you go to a third doctor to see if you can find a doctor who will take your problem more seriously than the first two.
  4. Peyronie's disease does not always cause a deformity, especially as early i the problem as you could be at six months duration.  Do not expect all cases of PD to demonstrate deformity, or to have it so soon; some do, and some do not.
  5. The small area of hardness you feel when flaccid that is the size of a ballpoint pen tip, could be your PD scar.  Did you show the MDs this area?  What was their response?  Many times a rushed medical examination will miss a small lesion like this.  You should have shown it to both of them, and demanded more time and attention to your problem. 
  6. Not all PD scars are rock hard. Some are so soft as to be almost undetectable.  This is why so many are missed on examination.
  7. Yes, you could have this much pain in the early stages of your problem.   It is amazing to me that you could have seen two doctors about your PD and not have been given this basic information. 
  8. Considering you were told you have Peyronie's and they only extended vitamin E as a treatment option, it is up to you to determine how you wish to proceed.  It is also up to you to determine the safety and appropriateness of undergoing a therapeutic trial of care for Peyronie's disease using Alternative Medicine  I cannot make that judgment; you have to take that responsibility for yourself.   I have had many men take this approach and were glad that they did.
  9. The PDI website is full of information for you to read and learn.   I suggest that you go the PDI website to learn how to start Peyronie's treatment if that is what you decide to do.  

Good luck to you and let me know if I can answer any questions as you look into this further.    TRH

Could Peyronie treatment plans still possibly help my congenital curvature?

I have been searching for a possible remedy for my penis. I have a slight downward curve, I believe it is congenital because I've always had it, and there is no scarring underneath my shaft or pain. Could your treatment plans still possibly help my congenital curvature? even if i don't have Peyronies? PLEASE HELP, this is causing me so much emotional discomfort doc!


The PDI Peyronie treatment plans are specific for Peyronie's disease.  However, I have been told by men who have congenital penile curvature that they used the information and technique from the PDI Manual Penis Stretching CD with great benefit.  I suggest you review that information to see if it makes sense to you and proceed accordingly. 

Additionally, since most congenital curves tend to be gradual and mild, I suggest that you could be making more of your lack of total straightness than it deserves.  Perhaps your values and sense of self-esteem exaggerate your emotional response to your variation.  It might be helpful for you to read "Peyronie's Disease and Sex" to get some insight into the way you are feeling about yourself.  TRH

Spontaneous Remission and Natural Cure for Peyronie’s Disease

Helping nature to remove the Peyronie’s plaque 

Peyronie’s disease is filled with unknowns and controversy. There is even controversy about how often this problem simply goes away on its own. Some say it never goes away; that once you have Peyronies you have it for life. And there are those who say it goes away half of the time, and those who say it rarely goes away on its own.       
The term “goes away on its own” is another way of saying “self-healed” or “spontaneous cure” or “the body healed itself without outside assistance” or a spontaneous remission of Peyronie's disease. This is not an example of playing with words. In my world of working to help men reverse their Peyronie’s disease by improving their ability to heal or correct this problem, there is no difference in what these terms mean. It is important – even critical – to realize that when the body is able to rid itself of a disease process or abnormality it is an instance of true healing or a self-cure. Hence, it cannot be said that there is no cure for Peyronie’s disease. The body is able to cure Peyronie’s disease; it happens either rarely, or up to 20-50% of the cases, depending upon whom you choose to believe – but it does happen.
This is an extremely important point to consider in regard to using Alternative Medicine to treat Peyronie’s disease. When you use the different internal and external therapies to rid yourself of the Peyronie’s scar all you are attempting to do is to increase your body’s ability heal or cure itself of PD.         
Most of us would be in agreement that the body can and does rid itself – by a process in which the immune system heals, or “cures itself” – of Peyronie’s disease. How often this happens might be of some disagreement, but I think it is fair to say that most people know the body is able to cure or heal the Peyronies problem in some cases. This is an important point to keep in mind when you read or hear that there is no cure for Peyronie’s disease.
When the medical doctor says there is no cure for Peyronie’s disease what he really means is that there is no drug that he can prescribe that is a Peyronie’s cure. We have established that the body can and does heal the Peyronie’s plaque in an undetermined number of cases. With the Peyronie’s Disease Institute therapy program we are attempting to increase that natural healing ability.   

Is cancer more difficult to treat than Peyronie’s disease?

A spontaneous healing, also called spontaneous remission or spontaneous regression, is the unexpected cure or improvement of a disease which previously appeared to be stable or worsening. These terms are typically used to explain unexpected improvement of a cancer. The spontaneous regression and remission from cancer was defined by Everson and Cole in their 1966 book, Spontaneous Regression of Cancer, this way: "The partial or complete disappearance of a malignant tumour in the absence of all treatment, or in the presence of therapy which is considered inadequate to exert significant influence on neoplastic disease."


Because most of our medical information is presented through medical sources, it has long been suggested spontaneous regressions, let alone cures, from cancer are rare. Frequency of spontaneous healing was estimated to occur approximately at the rate of 1 in 100,000 cancers. Everson and Cole report that at least for small tumors, the frequency of spontaneous regression had been was drastically underrated and underreported. In their carefully designed mammography study they found that 22% of all breast cancer cases underwent spontaneous regression. They explain spontaneous regression from cancer: "In many of the collected cases … it must be acknowledged that the factors or mechanisms responsible for spontaneous regression are obscure or unknown in the light of present knowledge. However, in some of the cases, available knowledge permits one to infer that hormonal influences probably were important. … In other cases, the protocols strongly suggest that an immune mechanism was responsible".

When you read that in 20-50% of the cases the Peyronie’s disease goes away on its own, these are the instances in which the body was able to heal itself of the excess Peyronie’s scar. This issue of spontaneous resolution and tendency for improvement of Peyronie’s disease has been commonly cited. 1-4 If the body can cure cancer on occasion, why not Peyronie’s disease if you are doing many things at once to encourage this to happen?
All of this should give you some encouragement that the Peyronie’s Disease Institute therapy program is following a logical and reasonable course of action to help the body remove this problem, as the body was designed to do.

Is it OK to eat only the white part of the egg while following the Peyronies therapy plan?

Hi Dr. Herazy, 

I have recently been diagnosed with Peyronies and I have bought your book and just started the medium plan.

I have always been interested in nutrition and thought that my diet was OK but now I realize that I actually need to change what I eat a lot. I am just about to change my diet based on the recommendations you have laid out in your book. However I have a few questions about the diet:

I have noted that eggs and diary products are on the avoid list. Is it OK to eat only the white part of the egg?

At breakfast I often eat porridge made of oat flakes and water together with cottage cheese, fruits and milk. Is it OK to still eat cottage cheese if it is low in fat if I cut out the milk?

The reason for these questions is that I try to understand what is not good with eggs and milk. I assume it is because of the yellow part of the egg with cholesterol and because of the fat in the milk. However there may be other factors so I would be most grateful if you could pls let me know if I can still eat cottage cheese and the white part of the egg. I want to have an aggressive approach to cure my Peyronies disease and I am ready to change my diet, do various exercises and follow my supplement plan as long as it takes.

Pls give a comment also on my plan as follows:

Daily I will take the following:

vitamin e factor 400/400 – 2 pills per day
vitamin e factor maxi-gamma – 1 pill per day
vitamin c natural c – 1 pill per day
vitamin c ascorbplex 1000 – 1 pill per day
MSM 10g per day – 5g in the morning and 5g in the evening
Fibrozym – 2 pills x 3 times a day
nattokinase – 2 pills x 2 times a day
Scar x – 3 times a day
DMSO + cupper + Unique E oil at least once a day after shower

Added to my plan:
Paba – 1 pill x 2 times a day
OmegaT – 1 pill per day
Quercetin Bromelain Complex – 1 pill twice a day
Acetyl L-Carnitine – 1 pill twice a day

Would be most grateful for any feedback. Thank you so much for having created this service. Rik

Greetings Rik,

Thank you for your diet questions and the detailed report on how you are approaching your Peyronie's therapy plan.  

You have obviously taken to heart the dietary recommendations found in chapter 5 my book, “Peyronie’s Disease Handbook”   In this chapter is discussed the dietary aspects of treating PD in which I present the idea that certain foods and styles of eating can contribute to PD.  

In that same chapter of the book that talks about different dietary issues, at the very beginning I say that most of the dietary suggestions are based on ancient Oriental concepts that are used in the practice of acupuncture and yin/yang.  I go on to say that it would require an explanation that could run for several books to completely and thoroughly explain these concepts.  You are asking a simple and direct question that from a Western standpoint should have a simple and direct answer – that makes sense.  But the answer is not so simple or direct – it is very complex without a good understanding of traditional yin/yang concepts. 

The chapter that you are referring to is very clear on this point,  that this list represents Eastern thinking, not Western thinking.   Many of the food items mentioned in the list to avoid are really good nutritional foods – from a Western standpoint.  However, these foods are not considered from a Western perspective but from an Eastern perspective.  This is where the idea of avoiding cheese, eggs and banana comes from; not from a nutritional standpoint but from an energetic standpoint.  It is not related to fat or cholesterol as you suggest, but from the Eastern concepts of energy creation, movement and stagnation of that same energy.  

The closer you follow these dietary guidelines, even it does not make sense to your Western thinking, I believe you will see your results follow. You can decide to eat all or part of the egg hte

If you really want to know more I suggest that you simply get several acupuncture text books and study the subject thoroughly.

Your PD therapy plan is balanced and is a reasonable start in Peyronie's treatment.  Congratulations.  There is nothing I can see that is essentially wrong with it.  As you are using your plan right now, it could help take you all the way to reversal of your PD problem, or it could be insufficient to help you.  There is no way to know if a plan is correct for you by looking at it.  You must put it into action and see what it does after 10-14 days to change or reverse the size, shape, density of your scar that is always the ultimate determinant if your plan is correct or not. 

If following this plan causes changes in your scar, then continue with your plan until your scar is either gone or stops responding to it.

If following this plan causes no changes in your scar, then modify it in some way and again re-evaluate your scar in 10-14 days to see if your scar changes in some desirable way.   If you need help in determining what to change in your plan, please provide a detailed description of your scar as you learned to do in chapter 4 of that same book so I might understand what is going on with you a bit better and I will offer you some suggestions to consider.

Follow your plan faithfully and aggressively and let me know if I can help you in any way.  TRH 

Will either of these Peyronies treatments also help with energy?

Will either of these treatments also help with energy? I am  thinking of ordering the Best Plan because of the curve.  My erectile dysfunction is really bad without taking a pill.


You did not mention any Peyronie's treatment in particular to know how to answer your first question. Since all metabolic processes in the body require the use of vitamins and minerals as found in all of the PDI therapy products I am sure you could say that using any of our plans would be helpful for energy conversion in the body.

The PDI Best plan is becoming our most popular of the three because it is so broadly based and aggressive in design.  It does not cost much more than the PDI Medium plan to resupply every month since the greater cost of the PDI Large plan is due to the one-time expense of the Genesen Acutouch therapy pens.  

Many men with PDI fall into the trap of erectile dysfunction since there are so many emotional issues related to dealing with PD.  Additionally, the Peyronie's plaque is notorious for disturbing the ability of the penile veins to close, and thus prevent blood being trapped in the penis as it should to create an erection.  

Let me know if I can help you in any way with your Peyronie's therapy.  TRH                                                                                   

Start with the large Peyronies treatment plan and other therapy later?

Dear Dr Herazy,

I have had PD for about 9 months and I am about to start the full PDI therapy programme, based on the advice you give in your book "Peyronie's Disease Handbook".  I received the PD Treatment Plan-Large, but I now notice that some of the recommended supplements were not included: Acetyl-L-carnitine, PABA, Neprinol, etc.

Can I assume that you recommend getting started with those supplements in the Large Plan and add others later?

Thanks Peter (based in France)


Greetings Peter,

The large Peyronies treatment plan does not include all available therapy items that could be used.  There are 12 different forms of therapy contained within the large plan, and as you correctly point out there are several that are not included. There are several reasons the large plan is limited to these particular therapies:

1.  Additional therapies might not be needed beyond what is in the large plan.  Many men do quite well on the large plan just as it is, and do not need to spend more time, energy and money using more therapies than these current 12.

2.  The wide variety of therapies in the existing large plan allow for enough opportunity to experiment with treatment dosage to take several months of active work.  If the large plan provides insufficient, then there are additional therapies to include at a later time for further experimentation.

3.  The large plan is time consuming to use as it is currently designed.  Making it larger would only place an unreasonable burden on men who might not need to spend additional time and effort taking an even larger number of pills. 

4.  The large plan is expensive at the current level.  Expanding the number of therapies would only prevent men from affording the higher cost of entry. 

Stay focused with that large plan; you will be busy.   TRH

18 year old wants help determining if he has Peyronie’s disease

I am 18 years old and need help figuring out if I have peyronie's disease. My penis first started curving to the left about 1 and 1/2 years ago. It was only slight so I wasn't too worried. About a week ago it curved a little more to the left and now I'm worried that it's going to get more severe. Since I was a kid (long before I had any curvature) there was always a slight lump on the right side of my penis. I believe it has gotten slightly larger recently. Do I have peyronie's disease? How do I stop it from curving more? And does masturbation cause it to curve more? If you could please help me out I would greatly appreciate it, I'm really stressing out over this.


Given your history of a longstanding childhood penile mass in someone who is currently 18 years of age, I strongly encourage you to consult with a urologist about your situation.  Since your penis curve is aimed to the left and you say your lump is on the right, those two findings do not seem to correlate; this is not typical of Peyronie's disease.  But is is not possible to confidently tell you if you have PD or not based on the limited information.  This is not the kind of problem you should attempt to figure out on your own.

If you have not told your parents or some adult you trust about your problem, now is the time to do so.  You do not have to go into great detail.  Just say, "I have a urinary problem and I think I should see a doctor."  If you are pressed for details, and you are uncomfortable giving any, you can always say, "I am really uncomfortable about this, and I would prefer to discuss this with a doctor."  Any reasonable adult should respect your right to privacy.   

Put aside any embarrassment you might feel and allow a medical professional to determine your diagnosis. Getting yourself examined to determine exactly what is happening to you would be the wise and mature thing to do.  Please let me know what you are told.   TRH 

Is there a specific treatment for Peyronie’s disease that occurs after a prostatectomy?

My PD occurred nearly four years ago after a laproscopic prostatectomy.  What is your opinion about the efficiency of your treatment after such a delay?   Is there a specific treatment for Peyronie’s disease that occurs after a prostatectomy?  Thanks, John 

Greetings John,

Peyronie’s disease is a fairly common reaction that can occur as a result of trauma to the urethra during a laproscopic prostatectomy.  I have discussed this bad result in another area of the PDI site, Possible Peyronies Cause: Catheter and Cystoscope Trauma

Many men start their PDI treatment plan three and more years after the onset of their problem.  Actually, it seems that many men begin PDI treatment three to five years into their PD problem.  At this time I have not noticed any great difference in the effectiveness and end results of those who have a late start or an early start working to increase their ability to heal and repair the PD scar.  What seems to be a more important factor for overall success of treatment is the level of faithfulness to the treatment plan and the diversity of treatment; those who follow a large and aggressive therapy plan and do it without deviation are usually most successful.

There is no special or different treatment for Peyronie’s disease based on how it occurred.  Your treatment would be the same regardless of how it started since it is the scar that is the important aspect of Peyronie’s disease treatment regardless of how it actually started. 

One of the important elements of a good treatment strategy is to do a variety of Peyronies disease exercises along with using vitamins, minerals, enzymes and herbs to support your natural recovery, especially if you notice the muscles and supporting tissues of the pelvis are tight since your surgery.  TRH

Do you think using vitamin E by itself will help my Peyronie’s disease?

Greetings Doctor,

My urologist recommended taking 400 I U of vitamin E daily when he first told me I had Peyronie's disease, although he was not too specific about the quality or type of vitamin E I should use, or anything else for that matter.  Before he ran out the door he did not say what the next step would be if that did not help me, but he did stress that I should return in six months for another visit.

Thank you for the helpful information about vitamin E on your Peyronies website.  At least I know now how to do it, and I will get mine from you so I know I will be taking the best vitamin E for this purpose.  I will try my doctors recommendation of just using vitamin E by itself and keep my fingers crossed.  Do you think using vitamin E  by itself will help my Peyronie's disease?   Paul

Greetings Paul,

No, I do not.  Vitamin E for Peyronies treatment is great, but it needs a lot of support from other kinds of therapy to get the job done.  And finger crossing has nothing to do with successfully treating your Peyronie's disease.  

Success is based on hard work, determination, dedication and focus to a broad based Alt Med plan that will increase your body's ability to heal and repair the Peyronie's scar.  I suggest you do all you can during these next six months to learn about your PD and the process of natural correction. The PDI treatment protocol has a high degree of success when it is done correctly.  The problem is that many men try to bastardize the PDI treatment protocol to save a few bucks, or is too lazy to do what is required, or is always looking for the easy way out.  I trust you are not that way.

Go ahead and follow your urologist's idea of using vitamin E as a solo therapy.  I have never heard of anyone who has been successful with this idea – and neither has your urologist.  He is just telling you to do that because that is what the text books tell him to say and he cannot get into trouble for repeating what is accepted current medical thinking. What is probably on his mind is that at your next office visit in six months he will be able to follow the same current medical thinking and tell you that you need Peyronie's surgery because the vitamin E did not work. They have a great thing going for themselves. 

I suggest you spend a little time on the PDI website educating yourself about the non-drug and non-surgical treatment of Peyronie's disease.  If you need any more information please let me know.  TRH     



If you miss a treatment dose does it matter?

Hi Doc,

If you miss a dose with either a therapy product that should be taken with a meal, or 1-2 hours before or after meal, does it matter?  Can you make it up?

Thanks for all your help.  



Greetings Bud,

Sure it matters. Can you make it up? No, not really.

So don’t forget.  That is what I mean when I say, “Stay focused.” You will get out of this what you put into it.

It does not take too long to learn that following an aggressive Peyronie's treatment plan is work, and it can be boring.  believe it or not, this is what makes some men so down on treating their PD that they quit after a few weeks.  Do not be one of those men.  TRH 

Should I add Neprinol to my Peyronies treatment plan?

Hello doctor,  My bottles of Fibrozym and Nattokinase from my first order are almost finished.  I am already beginning to see my scars getting smaller and softer so I am really encouraged.   You had recommended replacing these two with Neprinol when I reorder my other therapy products.  Is this the best time for that order of Neprinol, or should I reorder Fibrozym and Nattokinase and also add Neprinol to my plan.  Thanks,  Larry


Greetings Larry, 

You are very early in your care and you are already seeing some positive changes, so I will assume that more change and progress is possible once you determine the best therapy plan for your particular problem.

Everyone must work to figure out what is the best therapy plan for himself.  I suggest you should think about doing this, based on your response to your current strategy: try using only Neprinol for awhile, and see what happens.  Experiment a bit and see what happens. 

Take the Neprinol in a slowly increasing dosage based on the general information you receive when you order from PDI. If taking Neprinol as the only enzyme therapy causes your positive changes to regress or slow down, then it is a mistake and you should go back to Fibrozym and Nattokinase – but it really should make a greater improvement. If taking Neprinol as the only enzyme therapy causes further positive changes, then stay with that for a while.  After a month or two of good changes on Neprinol only, then continue using Neprinol but add Fibrozym and Nattokinase back into your plan so you are taking three enzyme products. See what that does to your scar reaction.

EVERYTHING gets back to how your scar responds. You and I can make up all kinds of treatment strategies, but you must test any of them against what they do to your scar.  It does not make any difference what you and I think might be helpful to reduce the PD scar.  You must prove to yourself that what you are taking is working by actually measuring positive changes in your PD scar.  This is the PDI treatment philosophy that makes sense to everyone.   

Your scar is the enemy – destroy it – and it will tell you exactly what it will take to do the destroying if you know what to look for in scar behavior.  However, you must be paying very close attention to what it is telling you in order for you to learn from it.  TRH

How often should a person with Peyronies use DMSO?

How often should a person with Peyronies use DMSO?  Can you use it daily with other topicals?   Will the stuff you put on after DMSO still go on?   Online it says put to put DMSO on LAST.  What if you put the DMSO on first is it still effective?


Based on the basic nature of your questions about DMSO (how often to use it; combining it with other topical therapies; frequency of application) I have the sense that you have not gotten your DMSO from PDI.  Anyone who buys from PDI knows the answers to these questions and more.  PDI provides specific information and details for correct use with all the PD therapy products we sell.  We help you every step of your journey so you get the best results you can; you would not have these questions if you were dealing with PDI.  And this brings me to my biggest concern about you…

Some men make the mistake of using the highest concentration OF DMSO they can find, thinking that stronger is better and it is not.  You cannot use effectively use a high concentration DMSO for PD treatment very long without it quickly irritating the delicate skin of the penis.   This is why PDI offers the PMD DMSO brand of DMSO that was formulated in cooperation with Stanley Jacobs, MD, the man who in the late 1950s did the first medical DMSO research on humans.   Our DMSO formula has the best concentration for PD treatment, and it also contains PABA, MSM and urea for added benefit.  No other DMSO product is made specifically for Peyronies treatment but our PMD DMSO. 

Lastly, I must mention that you need to be very careful what you combine with DMSO when it is on your skin.  You mention applying "stuff" with DMSO.  This concerns me.  I have had contact with many men who decided to experiment by applying all types of chemicals along with DMSO over their PD scars.  Some men have crushed up and diluted drugs, applied solvents, slats and hormones and added DMSO to their experiments.   All of this can be extremely dangerous and counterproductive.  Please do not experiment with DMSO in this way.     

Now that I have had my say about DMSO in general, here are the answers to your questions:

DMSO can be used up to three times daily. 

It can be used daily with other appropriate safe topical therapies. 

It is best to apply DMSO last if you are also using other topical therapies; if you apply DMSO first there will still be reduced transfer of those topical therapies you applied first.     

Is it normal for the flaccid penis to change texture?

This may be a silly question, but here goes. Is it normal for the penis in the flaccid state to change texture. Sometimes my penis in the flaccid state is soft and long and sometimes its as hard as a rock and short.  Is the scar tissue causing this?


You pose your question asking about the flaccid state of your penis presenting different textures, and present your observations that seem to be contradictory. 

You mention one state is soft and long, and the other is hard and short.   This last description sounds very much like an erection that is  shortened because of the inability to lengthen due to contraction of the penile soft tissue, and not another state of a flaccid penis.  It is not consistent to say that you are both flaccid and hard as a rock.   For the most part, you are either soft or hard, flaccid or erect, but not at the same time. 

The erection process is complex and the presence of the Peyronie's plaque or scar, a foreign mass of collagen tissue situated within the erectile tissue, can created some unusual reactions and alternations of the usual erection a man can experience.

I think perhaps what you are confusing is the lack of lengthening of your erect Peyronie's penis with still being flaccid.  TRH

Question about Peyronie’s treatment

Dear Sir,

I M.A. Mujeeb from India is suffering from Peyronies. Up to May 2010 I was quite well in sex but May or June 2010 onwards my penis is bending from both side (stem side and ring side) While incursing I am getting pain. I request you to tell me whether this medicine is effective for the above problem for me.

Thanks and regards,



Greetings M.A. ,

Any or all of the different Peyronie's treatment ideas found on the PDI website can be successful when combined in an aggressively and faithfully applied treatment plan.  The likelihood for that success is increased by following a broad based plan that includes both systemic, topical and external therapies.

Even if you did mention several Peyronie's therapies there is no way for anyone to intelligently predict the outcome of your use of any therapy.  Treatment results is far too complex, with far too many variables, to give a meaningful answer to your question if you could be helped.  It is always something that each man must attempt to learn for himself how he will respond. 

To assist you I suggest you read at least a few of these articles:  "Peyronie's disease treatment frequently asked questions" and  "Peyronie's treatment philosophy" and "Peyronie's disease natural treatments: introduction."  





Is it possible my Peyronies plaque or scar is like a piano wire?

Dr. Herazy, I wrote you last month and you really helped my confidence with what I am doing. Is it possible that my PD scar is like a piano wire from the base to the head? That is the only irregularity I can find. Thanks Dick R.

Greetings Dick,

Yes, it is certainly possible that your scar feels like a piano wire. The Peyronies plaque or scar material presents in a wide variety of ways, just as most everything about PD seems to be variable. 

Although you did not say so, I will guess the long ridge of scar material tissue you say feels like a piano wire is located on the top or dorsal surface of the shaft.  This is a very common location for long narrow PD scars.  It is the anatomical structure, called a septum, where the tunica albuginea of the two chambers meet in the mid-line, and it runs from the base of the penis to the head (glans).   This septum is especially susceptible to separation during trauma, and can consequently develop a long thin scar.  

You can assume this is your only, or your primary, Peyronie's scar if your curved penis is directed upward.  

While you might be correct that it is only as thin as a piano wire, I suggest that you examine this thin ridge again to determine if you can detect that it tapers down to a flat band.  Almost like the gable roof of a house, your piano wire structure might just be like the uppermost ridge of the roof that gets thinner as it slopes down laterally.  I mention this speculation because it is always beneficial to have a clear and accurate visualization of each scar so you can closely monitor it  for changes as you continue to treat your PD. 

You might find, if I am correct, that this flat tapered surface on either side of the piano wire will undergo changes in size, shape, density and surface features as your scar deteriorates as your treatment progresses. 

If you do not know it is there, you will not have this useful information available to you to guide your treatment.  You must try to know everything there is to know about each of your Peyronies scars.


Do you think this is a bad idea?

Can you tell me what you think of using DMSO and possibly vinegar since it contains acetic acid, i used it and it didn't hurt but the mixture got very warm to almost hot, and it wrinkles the skin, i got this on a website… Wikipedia and other sources say….Diluted acetic acid is also used in physical therapy to break up nodules of scar tissue via iontophoresis. So can't you use dmso to deliver the acetic acid in vinegar similar to iontophoresis to break up peyronie's plaque? Do you think this is a bad idea to try?



Yes, I think this is a bad idea.  You got lucky that you only felt a hot sensation and that it just wrinkled your tissue.  I suppose had you left the vinegar on longer, or used it a second time, or in some other way increased your exposure to it, you would have probably developed a deep and serious burn of the penile tissue.  Do you know what would have been the likely result of a burn-injury to the deeper tissue of the penis for someone who already has Peyronie's disease?  More Peyronie's disease. 

Acetic acid of vinegar is a dangerous acid that will affect different tissues of the body in a variety of ways. The thin tissue of the entire genital region is unusually vulnerable to a burn injury caused by acetic acid.  When it is combined with DMSO the damage can be even more severe. 

Please do not do use vinegar again this way for your Peyronie's disease.  TRH