Should I change my Peyronies treatment because I am younger?

Hi,

www.howtoincreasepenisize.com

I am a young man in my thirties. My torture with Peyronie's started two years ago. Following masturbation I damaged myself at the tip of my penis.  I knew at the time is was a major event and one that would change my life irreversibly for the worse.  It was caused by pulling the foreskin back too far with force.

Following it, I had considerable pain for a year and a half. I went to casualty, multiple doctor's but no-one could tell me what it was. Surprisingly, the first doctor I saw guessed maybe Peyronie's because I had a bit of fibrosis at the tip but it was not a nodule – it was clearly calcification along what I thought was a nerve. It soon circled round the head as a thin band. The pain continued and intensified and after a few operations on the skin, a circumcision was suggested as the only cure.

I had that done and it removed the ring of tissue, but no I just had pain when I came to a climax. The original injury happened just before climax so I hypothesized that it was still the same problem. Gradually the pain turned into Peyronie's with a big nodule just behind the head, neither at the top, bottom, left or right but in the middle. Where I had the pain at the top left, scar tissue was forming. The pain was intense, day in, day out. I am a very fit young man and nothing seemed to stop it, sometimes its subsides but then it comes back to remind me and worse than before.

I have tried pentox with Cialis and also Tamoxifen having gone to a specialist. I am quite well studied and just can't understand this disease. I also tried using a stretching device but that was the worst advice in my opinion and stopped quickly afterwards. I have read studies, have read your book and am interested in what happens to younger men.  No one seems to know. I am 1% of a sample size of 1% of the population – aren't I lucky. I am not giving up, your book makes a lot of sense which is why I started off with your mid plan and have now bought everything I can get my hands on. I do take pentoxyfilline at the same time though as I feel it does help blood flow although it doesn't fix anything.To summarize therefore, at the moment, I have changed my diet (as much as I can), now just started taking everything on your list (although I am still nervous about DMSO but it is a calculated risk) and pentoxyfiline.

Having said that, it is all slowly getting worse. I have days with intense pain and all the time I have some pain. I think your point about digestion is valid as I do struggle with digestion and find it hard to go to the toilet.

I would really like your help. Currently I have a very fibrous penis all throughout. Sometimes it feels better than others but it isn't good. I am a positive guy but I am at my limit. I have a beautiful girlfriend who doesn't mind and I am great at sex, but I can't climax. I don't actually have pain during intercourse but erections are getting harder.

My personal hypothesis is that Peyronie's is caused by a chemical that is released through damage. In my case it is a nerve at the tip of the penis. This chemical went everywhere due to the great trauma and now the scar tissue is just finding where the chemical is. If I can find the inhibitor, I might get my life back.

What are your thoughts? I may be barking up the wrong tree but I need hope. In short, forget my hypothesis, is there anything I should do.  Should I change my treatment because I am younger? Should I take more of one thing and less of another? I am completely open to ideas. Like I say, I think it is beatable at any stage, you just have to find what works for you. I think there are many types of Peyronies caused by many types of things (which is why drug treatments are inconsistent).

Let me know what you think. I really appreciate your approach and thoughts.

Many thanks,

Steve

Greetings Steve,

Welcome to the large body of men who do not understand Peyronie's disease.  PD is a mass of contradictions and irregularities and this accounts for the ongoing difficulty not only in making a diagnosis, but also treatment.

You ask for my thoughts.  To begin with, several aspects of your story makes it sound like you have an extremely atypical, or not standard, case of Peyronie's disease.

Your 2nd and 3rd paragraphs are very interesting.  Bear with me, but based upon the scenario of the development and progression of your problem as you present it, I can make a different interpretation of your problem.  From a slightly different vantage point I interpret your report differently.  I can see it is possible that your penile problem was not originally Peyronies.  It is possible that you only developed later into Peyronies after the rigors of “a few operations on the skin, plus a circumcision. Starting a penis problem by pulling the foreskin tightly down tightly during masturbation, a superficial and circular pattern of fibrosis at the tip of penis, and constant severe pain for 18 months are not at all typical of PD; fundamentally, Peyronies is a problem of the tunica albuginea located in the shaft, not in the tip of the penis. Your problem is not even in the usual location for it to be Peyronie's disease.  Furthermore, you do not mention a deep nodule in the shaft and you do not mention penile distortion.  Very little of your initial complaints during the first 18 months of your ordeal sound at all like Peyronie's disease.  It is only later, after you were under medical care and had several penis surgeries for these unusual complaints, when you were probably catheterized several times or used Cialis several times, or were traumatized while using a mechanical penis stretcher, that you started to have complaints more consistent with Peyronies. 

I mention this observation because it is important for you to explore the possibility that you are dealing with a complex problem that could actually be two or more different problems that are superimposed on top of each other.  Perhaps I am incorrect in this regard, but based on what you have reported in your statement I think the case could be made that you initially had a superficial tissue abrasion or tearing that later developed into fibrosis, and only after receiving drug injections into the shaft during surgery or from catheterization after surgery did you develop PD.  Something to think about. 

You ask if you should change your plan because you are in your thirties, which you apparently consider to be younger than average to develop PD.  Based on many years of experience, you are not young to have PD; many men I would with are in their 30s, and 20s; I deal with many sad cases of teenage boys with PD.

Regardless, whatever your age might be, age is not the reason to change your plan. You should change your plan because whatever you are doing is not working; if your current Peyronies treatment plan is not providing benefit or improvement, and you have not changed it by now, then you definitely should change what you are doing.  You did not mention how you are using your medium size plan, or what your individual dosages are, so there is no way for me to suggest how to best modify your plan since I do not know what you are currently doing for yourself.   

The best way to handle this is by working together in direct discussion during a telephone call.  We can get a lot done in just 30 minutes or so if we put our heads together.   Please go to the PDI website to arrange for a telephone call together so you and I can directly discuss your situation in detail.  TRH

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Is it possibile for Viagra, or any other medication, to cause Peyronie disease?

Is anyone doing research on the possibility of Viagra causing Peyronie disease or any other type of medication causing this disease?  Mine seems to have started after I took Viagra . Thank you,  Floyd Mathis

 

Greetings Floyd,

Sorry to hear of your problem with Peyronie's disease.

Yes, there is growing evidence that Viagra, Cialis and Levitra (all the PDE5 inhibitor drugs) can cause Peyronie's disease in some men.  I have reported this and written about this observation for many years now.  You can read more about this topic in these posts from the PDI website:  Viagra Peyronie's disease connection and Viagra, Cialis and Levitra Use with Peyronie’s Disease and Peyronie’s Disease Plaque, Viagra, Cialis, Levitra, and Blood Supply .  There are more articles that are available but I think you will get the idea from these. 

The basic way the injury happens that leads to the start of Peyronie's disease is from "over inflation" that damages the internal tissue of the penis called the tunica albuginea.

I was talking to a man the other day from Australia whose PD started from just a single use of one of these PDE5 drugs. He told me that he developed an erection that was so hard and large that he was scared what might happen to him.  He said he thought he might explode.  Obviously that was the last and only time he took any drug like that.  About two months later he had three internal Peyronie's plaques and a curved penis of 45 degrees.  Because he did not have any sexual activity for months before that event or after it he is positive it was the drug that injured him. 

He went to his medical doctor who told him that this sometimes happens to men.  You will notice that there is a caution on inside drug product information that warns that men with PD should not use these PDE5 drugs.  

What strikes me as especially careless and inappropriate is that there are medical doctors who actually prescribe Viagra, Cialis and Levitra to men who already have Peyronie's disease to help them have an erection when they show signs of erectile dysfunction.

Yes, there are other drugs that are said to be associated with or to cause Peyronie's disease.  The common list includes beta blockers used for heart problems and all of the statin drugs used to lower cholesterol.    

I suggest that you review some of the Alternative Medicine treatment ideas on the PDI website to learn how you can use Peyronie's natural treatment to help yourself correct this problem.  Please let me know if there is anything I can do to help you.  TRH 

Is there a connection between using Cialis and Peyronies disease?

Is there a connection between using Cialis and Peyronies disease? The reason being is because I had no signs of the disease developing. I woke up one morning to find the scar/plaque on my penis when I went to the bathroom. Overall I took about 13 pills over 6-7 weeks, only taking one at a time. My doctor examined me and confirmed that I have it but did not offer anything solutions or why it happened. He did say he was surprised that it just came on as fast as it did which was like overnight for me.  I know my body and I was completely surprised.

Greetings,

Cialis is a member of group of drugs called PDE5 inhibitors, used to treat symptoms of erectile dysfunction (ED). Other members are Viagra and Levitra.

Yes, there definitely appears to be a connection between using Cialis and Peyronies disease.   Over the years I have encountered many men whose Peyronie's disease started after using just one dose of a PDE5 inhibitor.  There are many lawsuits pending in this regard.

Here are a few of the posts I have written about this subject over the years: Peyronie's disease plaque, Viagra, Cialis, Levitra and blood supply, and Peyronie's disease treatment and Viagra, Cialis and Levitra; there are others if you look further on the website.  TRH

What are your thoughts about Peyronie’s disease after second prostate biopsy?

I never had a problem with my penis til the last year. I am 63 yo, WM who has had two prostate biopsies over the last 6 yrs…each biopsy came back negative. After this second biopsy I notice my cock bends towards my tummy when erect and that it has lost about 3/4 of a inch…this is substantiated by my wife. Also, I have trouble obtaining and maintaining a erection even with the use of ED drugs.  Please help with your thoughts.

Thank you,

Peter Martin

Greetings Peter,

Your upward distortion and lost of penile length suggest the possibility of Peyronie's disease.  I suggest you have yourself examined to see if that is true or not.  I also suggest you go to a urologist different than the one who did the biopsies to assure a more non-biased and straightforward discussion.

Many men with Peyronie's disease develop it as a result of repeated catheterization associated with prostate surgery and biopsy.  Please refer to "Possible Peyronie's Cause:  Catheter and Cystoscopic Trauma."   Much abuse to the shaft and urethra can and does take place during these procedures and this could lead to Peyronies disease developing; since this traumatic effects tend to accumulate, all the more so.  

Further, repeated use of ED drugs (PDE5 inhibitors like Viagra, Cialis and Levitra) can also lead to a curved penis.  For more information you should read "Peyronies and Viagra" and "Peyronie's Disease Plaque, Viagra, Cialis, Levitra and Blood Supply."

There are some good things that Alternative Medicine can offer you in the way of Peyronie's treatment.  Please read the PDI website for information on a way out of using more drugs and procedures that can make your problem worse than it is now.   TRH  

Herbal products to help with ED sex problems associated with Peyronie’s disease?

I believe I got PD using ED drugs been married 30 yrs & need some erection help. Have stopped using the drugs, can you suggest something herbal I can use to replace them. Thanks Dave

Greetings Dave,

What you report is rather common.  I have communicated with hundreds of men who tell me their Peyronie's disease and sex started after using PDE5 inhibitor drugs (Viagra, Cialis, Levitra); this can happen after just one use or repeated uses.  For more information see Peyronie's disease and Viagra, Levitra and Cialis and Peyronie's treatment and Cialis.

If you go to the PDI shopping cart and scroll about 3/4 the way down until you see BetterMAN and about 5-6 other sex stimulant products. The most important of the group is a product called Stimulin. You would definitely want to include Stimulin with whatever else you use.  

All of these herbal products are much more gentle than your drugs and will not worsen your PD problem.   Many men use them while undergoing their natural Peyronie's treatment plan.  TRH

What is my opinion of prescription drug injection?

What is the Dr's opinion on using the prescription Edex injected with a syringe? 

Bryant from Ohio

 

Greetings Bryant, 

You ask for my opinion about Edex injections.  I will not comment on the drug, because that is the decision of your treating doctor.  But I will make a few observations about injections in general and how they could further injure the tunica albuginea.

Anytime you inject ANYTHING – even sterile water – into the penis and directly or indirectly contact the delicate tunica albuginea, you are taking a serious risk of making your Peyronie's disease worse. This could either occur just from the simple act of piercing the tissue of the tunica albuginea, or the placement of a concentrated chemical that is foreign to that tissue, or both.

I have communicated with many, many men whose Peyronie's disease started or was made worse from penile injections of a variety of substances.

If your problem is PD, why are you taking an ED medication? Some MDs prescribe Viagra, Edex, etc to their PD patients in the belief that this increases the local circulation which in turn is beneficial to PD.

What if you could take a drug that would enable you to lift a ton of weight above your head and keep it there for an hour? Nice trick, very impressive, but your body is not built to take that kind of pressure. It would cause great damage to internal organs, your spine, your blood vessels, all major joints, etc. Simply put, “It just ain’t natural.” Same with Viagra, Levitra or Cialis. The increased pressure created by these medications can be very damaging to the delicate tunica albuginea, and can result in or worsen a case of PD. What would happen to your car tires if you happened to over-inflate them with 100 pounds of air pressure, even though they were built to take just 40 pounds of pressure. You would be running the risk of damage to the internal structure of tire, wouldn’t you? Of course.

The same thing can happen if the penis is over-inflated and then given a “rough ride.” This is where the problems start, and this is what I wanted to bring to your attention. It is very likely that the MDs who prescribe these medications to men with PD will not agree with this thinking. MDs tend to favor a chemical “fix” even if it is temporary, so you would tend to expect a prejudice from an MD to use drugs to solve most problems.

A penis that is predisposed to PD in the first place cannot tolerate the kind of stress that these erections drugs create.  If you think independently and logically about what happens when these drugs are used, you should have no trouble understanding how this could work against you.  That is just the way I see it and I feel compelled to share this rationale with you. Use of Viagra and other related meds like it could easily be worsening the very problem you are attempting to heal. Something to think about.  TRH

Pentoxifylline and Peyronie’s Disease Treatment

Pentox for Peyronie’s treatment is an off-label use

Every now and then I get an email asking for my opinion about using Pentox (Pentoxifylline) for Peyronie’s disease treatment.  Over time I have developed a few ideas about this controversial drug that is gaining some popularity as an off-label Peyronie’s treatment.

Those MDs who prescribe Pentox are still trying to figure out the best way to use it, not only for PD but for many other conditions.  While the primary use for Pentoxifylline is based on its ability to increase peripheral blood circulation, hence it is used to treat senile dementia and intermittent claudication, Pentox is gaining acceptance with the medical community for Peyronie’s treatment.

Some MDs who have learned the hard way that PDE5 drugs (Viagra, Cialis, Levitra) are not at all a safe or effective Peyronie’s treatment have instead begun to prescribe Pentox to increase blood flow in Peyronies.   But to have that make any sense at all you have to believe that PD is caused by reduced blood flow in the first place, or that merely increasing the blood flow will somehow help PD.  I can totally agree with that thinking if you have evidence that your penis suffers from reduced blood flow (it is cold and blue).  But if your penis is not cold and blue and bent, then you probably will not benefit from Pentox in the way that most people think.

It is my opinion that when Pentox is said to help men with PD it is because as the blood flow is increased to the periphery, it also brings in an increased flow of nutrients to assist the healing process.  Further, when Pentox helps a case of PD it is because of the totally secondary benefit of increasing the body’s ability to heal and repair the PD plaque when there are more nutrients in an area of the body.   It is a small point, perhaps, but a vitally important point to understand that it all comes down to the body healing the PD scar – not the Pentox having some curative ability by itself.   If Pentoxifylline can increase general circulation more safely than Viagra, Cialis, and Levitra, then great I am all for that.  But you have to consider that if you do not have a circulatory problem in the first place, then why take any of these drugs at all?

If the benefit of Pentox is to bring more nutrients into the tissues, to assist healing and repair of the PD plaque or scar, that is wonderful.  If it is beneficial to bring more nutrients into the tissue, would it not be a more logical and effective Peyronie’s treatment to intentionally and intelligently supply a wide variety of nutrients at a higher than average dosage to the body to assist the healing process?  After all, that is what PDI has been doing since 2002 and it works in a great percentage of cases when it is done correctly.

Since extremely few men actually have any evidence of a circulatory problem in the pelvis, taking Pentox or even Viagra, Cialis, and Levitra, will not make a difference because that is not the problem that is going on with PD.   If the problem is that you did not heal your tunica albuginea injury because of poor nutrient availability then I suggest it would do you a lot of good to increase the nutrients directly, not indirectly by playing with the circulatory system when there is no circulatory problem.

You notice that I do not say, “Do not take Pentox,” I only say it is new so use caution.  I also say that when Pentoxifylline helps it probably does so only because it helps the body work better by increasing available nutrients, not because it specifically increases blood flow.  If you want to help your pelvic blood flow:

1.    Wear boxer shorts

2.    Uncross your legs when you sit

3.    Do some Kegel exercises

4.    Put a moist hot pack on your privates when you watch TV

Most MDs are taking the attitude that while they do not know if Pentox helps PD, or why it helps when it appears to help PD, at least they currently have no evidence that it makes PD worse – so what the hell, take it and let’s see what it does for you.  This is how many medical patients get hurt in the long run with such a cavalier attitude about drugs.

I say better to take an Alternative Medicine approach to your problem to help your body heal and repair the Peyronie’s pathology naturally.

Viagra Peyronie’s Disease Connection

Greater Viagra use and increase of Peyronie’s disease

 

In a 2002 article in the International Journal of Impotence Research about possible causes of Peyronie’s disease, authored by Sikka and Hellstrom of Tulane University, these two medical researchers observed that with the increased use of Viagra, Peyronie’s disease also increased.

In my work with the Peyronie’s Disease Institute, while corresponding with six to 10 men daily who have Peyronie’s disease concerning various aspects of their problem, I have also made this observation – that with greater use of Viagra, Peyronie’s diseases clearly increases.  The difference between Drs. Sikka and Hellstrom’s and my explanation why Peyronie’s disease is becoming more common as the use of Viagra – and other PDE5 drugs like Cialis and Levitra – increases around the world.

Their explanation, quoting Drs. Sikka and Hellstrom’s report:

“Peyronie's disease usually affects 13% of males between the ages of 40 and 70, and the number of patients with such lesions have increased since the advent of oral sildenafil (Viagra, Pfizer) either because more men are becoming manifest and/or not hesitant anymore to come to clinics for such evaluations.”

In other words, these two Tulane researchers say the only reason PD appears to be increasing is that more men are willing to talk about it, now that men are talking more about erectile dysfunction with the greater awareness brought about with the frequent TV and magazine ads about this problem and drug solution of it.

While they offer the simple explanation that because men are becoming less hesitant to talk about their sexual problems, they assume more men are inclined to enter medical clinics asking for help – like asking for a prescription for Viagra, Cialis and Levitra.  That is certainly a possible explanation of perhaps some merit.   But that does not match my experience in talking with men who actually  have Peyronie’s disease.

Peyronie's and Viagra

Men I talk to about starting Peyronie’s treatment still ask about how the mailing package will be labeled and if the return address will mention “Peyronie’s disease,” lest their letter carrier will learn they have PD.   I am asked if the credit card statement will mention that their therapy products are for treatment of PD, lest someone at the credit card company will learn they have PD.   I am asked by men how to explain the problem of Peyronie’s disease to a new girl friend so that she will not be scared away from a relationship with someone who has a disease of the penis.  I talk with men who do not want to talk at work about their PD lest someone overhears the conversation.  I learn from men that the worse thing about PD is not the pain associated with the scar development, but the loss of penile girth and length – something that most men would seem hesitant to tell the world about.

I do not doubt for an instant that men are more relaxed and casual about admitting to a problem with erectile dysfunction, and more willing to ask for a Viagra prescription than they were a few years ago.  This is a more sexually open society – for good or for bad.  Yet, I doubt that men are just as willing to admit that they have Peyronie’s disease in which their penis is shockingly smaller than average or that can be so distorted as to be incapable of entry to engage sexual intercourse.

Erectile dysfunction is one problem related to advancing age that perhaps has some dignity related to it and hope of easy drug solution, but Peyronie’s disease might not be seen in the same way since it is associated with permanent deformity and reduction of the size of the male organ.

My opinion is that Drs. Sikka and Hellstrom are reluctant to discuss the possibility that these PDE5 drugs sporadically, irregularly and without warning cause severe injury to the tunica albuginea by extensive over-inflation of the corpora cavernosa of the penis.  The mechanism of this possible route of injury was discussed on 8-17-09 in the Peyronie’s Disease blog under the title, Peyronie’s Disease Treatment and Viagra, Cialis and Levitra, and again on 8-1-10 under the title Viagra, Cialis and Levitra Use with Peyronie’s Disease.

These doctor’s hesitance to discuss or speculate that the increase of PD parallels the increase use of these drugs due to yet another drug side-effect of yet another group of drugs itself can be speculated upon.   Each man with PD must make up his own mind if this possibility makes sense to him, and if it is further reasonable to avoid the use of these drugs if he wishes to avoid further injury to his penis.     

Cause of Peyronie’s Disease

Trauma frequently seen as Peyronie’s cause

While the cause or causes of Peyronie’s disease remains open to speculation, some theories are more popular than others.  However it starts, it is important to remember that Peyronie’s disease is a disorder of the tunica albuginea.

Among the several explanations for a possible Peyronie’s disease cause, trauma or direct injury to the penile shaft is almost always mentioned as either a primary cause or at least a significant secondary cause.  More specifically, the cause of Peyronie's disease is universally explained as a wound that does not heal in the normal way, whether related to injury usually associated with sexual activity or a medical procedure. Even when other causes are mentioned it seems that injury will usually be associated in some way.

Role of wound healing in Peyronies disease cause

The penis contains two sponge-like, tube-shaped chambers (corpus cavernosae) with many tiny blood vessels that fill with blood during an erection.  Below the two corpora cavernosae is the corpora spongiosum through which runs the urethra or passage way to release urine from the bladder.  Each of the corpora cavernosa are enclosed in a thin and flexible sheath of elastic tissue called the tunica albuginea, which stretches slightly during an erection. Injury to the penis can cause inflammation and damage to the tunica albuginea.

If an injury heals as it should then usually there are no long-term problems.  But if the healing of the injured tunica does not proceed as it should, it can lead to excess internal scar formation, known as Peyronie’s disease.  The area of the injured tunica albuginea is not as flexible as before injury.  With the area less flexible, when the penis attempts to become erect the region with the scar tissue doesn't stretch, and the penis curves, bends, develops a dent or becomes distorted in some other way (bottle neck or hourglass deformity).

The tunica albuginea has many layers, with very little blood circulation between them.  When an injury to the tunica albuginea occurs, the tissue fluids associated with the inflammatory process can remained trapped between these layers for many months. During this time the cells found in the inflammatory fluid can release chemicals that lead to increased formation of fibrous tissue (fibrosis) that causes reduced elasticity of that area, internal scar tissue and possibly calcification.  The combined effect of these tissue changes is the characteristic penile deformity associated with Peyronie’s disease.

Inherited abnormality as cause of Peyronie’s disease

There is some evidence of a genetic cause or predisposition to PD related to an inherited abnormality of human leukocyte antigen B27 (HLA-B27).  Peyronie's disease is statistically more likely to occur in men whose immediate family members also have PD, or systemic lupus erythematosus (a connective tissue disorder).  PDI research shows that 37 percent of men with Peyronie's disease also experience Dupuytren's contracture, in which hard contracted develops on the palms of one or both hands.

Other conditions as cause of Peyronie’s disease

  • Vitamin E deficiency has been associated with the Peyronie's disease, primarily because early Peyronie’s disease research showed treatment with vitamin E demonstrated success in a significant number of cases.  Since that time less interest has been shown in using vitamin E as a Peyronie’s treatment.
  • Inderal and the PDE5 inhibitor class of drugs (Viagra, Cialis, Levitra) used to chemically stimulate development of an erection have been known to cause Peyronie's disease.
  • Diabetes when severe or prolonged will precipitate damage to the blood vessels in any area of the body, including the penile shaft.  PDI research shows that 21 percent of men with PD also have diabetes.

Regardless of the cause of Peyronie’s disease, it is important to start treatment as soon as possible to increase your ability to heal and repair the underlying injury to the tunica albuginea. Refer to the Peyronie’s Disease Institute website to learn how to start Peyronie’s disease treatment using Alternative Medicine.

Drugs Can Cause Peyronie’s Disease: Beta blockers & PDE5 inhibitors

Prescriptions drugs that start Peyronie’s disease

The cause of Peyronie's disease remains unknown.  However, among the more commonly suspected causes are injuries as during intercourse, penile trauma as during a difficult catheterization procedure or surgery, genetic predisposition, or a problem of the immune system.

Because medical Peyronie’s disease treatment is also poorly defined, with no standard drug receiving formal approval, one must wonder about the drugs that are currently being prescribed by medical doctors for their Peyronies patients.

Several prescription medications list Peyronie's disease among the potential side effects.  While no formal research exists that proves these medications cause Peyronie's disease, presumptive evidence and frequent patient complaints of strong association with these drugs supports these as possible causes.

  1. 1. Beta Blockers – These are the most common medications in popular use that list Peyronie's disease as a potential side effect.  Beta blockers is a class of drugs used for various indications, but particularly for the management of cardiac arrhythmias, protection of the heart after a myocardial infarction (heart attack), angina pectoris, atrial fibrillation, cardiac arrhythmia, congestive heart failure, glaucoma, migraine prevention, mitral valve prolapsed, and hypertension (high blood pressure). They tend to diminish the effects of epinephrine (adrenaline) and other stress hormones in the body, thus reducing cardiac demands.  If you have ever been treated for any of these conditions, and were treated with a beta blocker, this might explain a current case of Peyronie’s disease. Commonly prescribed beta blockers:

Acebutolol                  Alrenolol                     Atenolol
Betaxolol                 Bucindolol                     Carteolol
Carvedilol                   Celiprolol                    Esmolol
Labetalol                    Metoprolol                  Nadolol
Nebivolol                    Penbutolol                  Pindolol
Propranolol                Sotalol                        Timolol

  1. Interferon – This prescription medication is used to treat multiple sclerosis, leukemia, and hepatitis.  Its manufacturers list Peyronie's disease as a possible side effect.
  2. Dilantin – This is a well established anti-seizure medicine, also reported by its manufacturers as a potential cause of Peyronie’s disease.
  3. PDE5 drug group (Viagra, Cialis, Levitra) – this is a group of inhibitor drugs that block an enzyme process of the smooth muscle cells lining the blood vessels supplying the corpus cavernosa of the penis.  As a result of this influence, these drugs act to increase blood flow in the penis in response to sexual stimulation.   The maker of each of these three drugs advises that men with Peyronie’s disease should consult with their doctors due to possible adverse effects on the penis.

The bottom line concerning all these drugs is that every one of them has side-effects and related ways of complicating the problem of someone who is already sick.  Drugs should be used with great reserve and discretion, and avoided if at all possible.

Once PD is present and a man learns that there is no known medical treatment available, he should consider using Alternative Medicine for Peyronie’s treatment options.  This is an option that the Peyronie’s Disease Institute has researched and developed since 2002, with considerable success.