Pain pattern not seen with Peyronie’s disease

my husband started hurting out of the blue real bad at the bottom of his penis and top of his testicles, but its deep inside.  the pain comes and goes but when he is hurting he can't hardly move or walk.  it don't hurt when he pees.



This pain does not sound like it is associated with Peyronie's disease.

I suggest your husband goes to your family doctor to have this checked out real well, and tell the other doctor all that you have written here.   TRH 


Does this sound like Peyronie's disease to you?

Hi Dr. Herazy,

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I’m glad to have found your site. I recently was diagnosed with Peyronie’s disease after having gone through numerous urologists who were stumped as to what the issue was. My initial symptoms were pain and swelling of the glans specifically the coronal ridge. This ridge now appears more pronounced than before and although I no longer feel soreness I have the sensation of the glans feeling separate from the shaft. Soon after I noticed a dent on the underside of the shaft right below my glans which is only noticeable when erect. This area also feels somewhat numb to touch. My glans also do not get as hard as before I had this dent. My urologist mentioned a “distal neurovascular bundle” which is obstructing and preventing blood staying in the head.

Have you come across such a dent accompanied by soft glans and what is the likelihood of this being permanent damage?

Suffice to say this has caused tremendous stress however I am optimistic that the body given the right conditions and support can heal almost anything.

I appreciate any comments or advice you may have regarding this matter,


Greetings Chris,

From the limited information I would say you have at best a Peyronie's-like condition. Peyronie's disease is not associated with a neurovascular bundle, but a formation of collagen and other cellular components within the tunica albuginea tissue layer of the shaft. Numbness, glans swelling, glans softness and ridge formation are not part of the Peyronie's picture. While an indentation does sometimes occur with Peyronies I think this is perhaps more of a coincidence of a similar phenomenon and does not offer sufficient support for the diagnosis you say you were given. Perhaps you misunderstood?

Keep in mind I did not examine you, and the others did see your problem, so my opinion is of limited value. But still this diagnosis does not add up to me. Further, you say that several urologists were at a loss to determine the nature of your problem. Perhaps this is just what you were told so that they were off the hook to give you a diagnosis.

From my experience it is common that when several specialists get involved in a problem like yours, it is common for them all to be more concerned about not offending each other or being guilty of contradicting anyone that the patient is often forgotten. I say see another specialist and do not tell him anything about the other doctors so that this next opinion is more honest. TRH


Are my excess keloids the same thing as Peyronie's disease plaque?

Last year I had some minor surgery to remove some moles.  When they healed, they healed with massive keloids which I understand to be excess collagen. Earlier this year, one day I looked down and saw that my penis was bent about mid-shaft at a 40-45 degree angle to the left.  I then later noticed there was a long lump on the left side and a couple of smaller ones elsewhere, one of which causes a depression when erect on the bottom mid shaft.  I also understand Peyronie's disease to be the result of excess collagen?  Is it just a coincidence that in a period of less than a year my body is producing excess collagen all over my body?  What should I do? I don't want it to get any worse.  If it does, its going to start affecting my sex life.


There is a cellular difference between keloid formation and Peyronie's plaque formation; they are not exactly the same.  While both problems involve an excess of collagen protein, there are cellular and other differences between the two conditions that differentiate them.  A keloid forms within a scar on the surface of the skin and is actually an overgrowth of type 3 collagen, known as granulation tissue; it is composed not only of collagen but other types of cellular elements.  A Peyronie's plaque has a similar but not identical cellular formation found only within the tunica albuginea of the penile shaft.  What is most confusing about this whole issue is that the Peyronie's plaque is often called a scar, although it is not technically a scar.  

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Pointing out the difference between the two problems:

1. People who have an abundance of validly diagnosed keloid scars on their body tend to statistically not develop Peyronie's disease.

2. Verapamil, which is a drug that sometimes affects Peyronie's disease, does not affect a keloid at all.

I suppose you could explain the development of these two problems at about the same time as just a coincidence.   What is most important is that you do something about the development of  what you say is Peyronies disease.  I suggest that you look at “Start Peyronie's treatment.”   TRH


Are your treatments effective for Peyronie's disease with an hourglass deformtiy?

I have the hourglass form of Peyronie's disease. The hour glasses is right at the base of my penis. In 15 months I have lost more than an inch in length. The specialist I saw indicated my scarring was severe. He also used the word very thick. He recommended injections to the penis. Although he sounded more skeptical then confident. My scarring is on both sides and the top of my penis. Like I said all scarring started at the very base.

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Are your treatments effective for this type. I am at a total loss as to what to do. My wife of 32 years And I have gone from sex 4 X a week to almost not at all.

I cannot believe how this has affected me emotionally.


There is much you can do to help yourself; do not lose hope and confidence in your body's ability to remove this problem. The treatment outlined by the Peyronie's Disease Institute is intended to restore and support your natural ability to remove the Peyronie's plaque like the 50% of men whose PD goes away naturally.

Many MDs will not consider delivering injections into the Peyronie's plaque because repeated injections into such a small area, usually over a series of 12 office visits, represents another form of injury. Usually 8-20 injections are given at a single office visit to a small area where the scar is located, and this is done at 12 different office visits. This represents a lot of pin holes created in a very small area of delicate tissue. For this reason injections can cause Peyronie's disease, regardless of the drug being used, simply because of what the needle does to the delicate penile tissue.

There does not seem to be any difference in response to Peyronie's disease that causes an hourglass deformity, or an bottleneck deformity or a curve or dent or twist or combination of any of these. Regardless of how the Peyronie's plaque affects the appearance of the penis, it all comes down to helping the body remove the foreign fibrous material. Please look at use of any of the suggested therapy plans to see which one makes most sense to you.

Many men are wracked by the emotional aspects of Peyronie's disease. I suggest you read “Peyronie's Disease and Sex.” TRH


Is treating penile scar tissue similar to treating Peyronie's disease?

Hi. Dr. Herazy

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My question is regarding the differences and similarities between Peyronie disease and that of scar tissue without a plague, and whether or not treating scar tissue is similar to treating PD. I've been told by 3 urologists that I do not have Peyronie's disease, merely scarring as a result of an injury.

Almost two years ago I suffered the injury to my erect penis during intercourse. It bent awkwardly, causing pain, but I did not show any signs of having suffered a fracture. My original urologist told me I might have bruised it, told me it should clear up in 3 to 6 months, then shuffled me out of the office before I could ask any questions.

Now two years later the pain and curve has progressed to the point of impotency. I believe partly because I suffered subsequent injuries when my wife and I were trying to get pregnant this past winter. Around this time I also woke up abruptly in the night after feeling a tear in my erect penis, causing it to now bend downward with considerable pain without support during erection.

I waited almost a year to see a specialist in my area who is considered one of the best. He is the most recent of the 3 urologist I've seen. I was almost certain he was going to diagnose me with peyronies, but after his examination and an ultrasound he said it is a large scar and not a PD plaque. He gave me Cialis and told me it should clear up in 3 months. I'm really tired of uro's telling me it will clear up in 3 months when it has only become worse.

I hope you can provide your general insights on my condition. I appreciate all you do.

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Greetings Andrew,

Part of the difficulty of answering emails such as yours is that I cannot get a full sense of all the necessary information I need to offer a reply I can feel comfortable with. You did not indicate why the MDs who have examined you thought you did not fulfill their criteria for making a diagnosis of Peyronie's disease. What symptoms or signs of PD do you not present that would have enabled that diagnosis?

I would like to assist you more, but at best all I can do is to suggest that you consider trying a brief therapeutic trial of care to determine if and how much improvement you might be able to make to assist your effort. Treating penile scar tissue can be similar to treating Peyronie's disease since the concept involves helping the body remove foreign fibrous tissue cells. The PDI treatment protocol could assist the removal of scar tissue in some cases; in your case you could simply give yourself a few months of treatment to determine how you respond.

MDs, even specialists, sometimes make mistakes. This could be substantiated by the fact that all three have been wrong about your problem clearing up in three months. Further, sometimes when one MD makes a diagnosis it happens that a 2nd or 3rd MD that is seen for another opinion will only “rubber stamp” what the 1st one said for reasons of not wanting to make trouble within a tight medical fraternity. It happens. TRH


Do you think I need a penis traction or penis extender device?


About 2 years ago I injured my penis during sex/girl on top slip. I noticed right away the right chamber close to the foreskin was not full. I have been fine up until a few weeks ago. Now I have a constant dull burning sensation in the area. My erect penis is not curved/slightly. But after I ejaculate it cures to the left. I'm am so scared and depressed. I ordered all these supplements from Dr Lin who people think is a quack. But I'm scared to take because there are so many ingredients in them, I have bad anxiety thinking about the side effects.

1.) do you think I need the traction device? I am really broke right now.. Poor I should say.
2.) are the supplements and creams safe you recommend?
3.) can you write out when I should take these, and when to use the creams. I didn't see instructions on the site.

Is this real? I am so depressed.

Thank you,


Greetings Christian,

You did not say so directly, so I will have to assume that you have been properly diagnosed as having Peyronie's disease. If you have not had that done yet, please do so.

Your description of the injury is very common, and taking about two years for active symptoms of PD to begin is also fairly common. Chances are that as the next year or two passes you will begin to notice more definite bending of your erections as the Peyronie's plaque develops. In regard to your questions:

1. I have no idea what traction device you are referring to. Generally, I take a stand against mechanical penis stretchers because of the injury they can create. Please see Penis extender claims and Peyronie's disease.

2. In over 10 years of working with the various supplements we use to support the ability to reduce Peyronie's disease there has never been a report of any problem more serious than a few days of diarrhea, that can be controlled by simply reducing dosage.

3. All supplements and therapies that you order from PDI come with complete instructions for correct and safe usage.

Peyronie's disease is real and can be a real shock when first diagnosed. Let me know if I can help you with ideas and comments. TRH

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If I stop taking the drug that caused my Peyronie's disease, can I expect that it will go away?

I have been on Sectral for approximately 20 years for mild-hypertension. I developed Peyronie's disease approximately 3 years ago. I am a 58 year old white male and weigh 195. I just learned about the relationship between PD and Sectral.

My question is… If I were to stop taking Sectral (under my Doctor's care) should I expect that my PD will go away or correct itself?

Thank you.

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No, stopping the drug that caused your Peyronie's disease would not reverse the progression of the tissue changes that have occurred over the years. In order to do that you would have to use one of the treatment plans you see on the PDI website to reverse the damage that has been done. TRH


What are the ingredients and concentration (%) of the DMSO to treat Peyronie's disease?

Have a few questions about the “PMD DMSO Gel” if you don't mind.

Was curious the ingredients or concentration(%) of the DMSO (dilution)?

I had some irritation before from a 80% DMSO, but I wasn't using it for Peyronie's.



Our PMD DMSO is a special formula that was developed specifically to be used for Peyronie's disease treatment. This formulation was created with the cooperation and help of Stanley Jacobs, MD, who did the original DMSO medical research that made it so popular in the late 1950s.

The PMD DMSO is a 60% DMSO, 10% urea, 10% PABA, 10% MSM, and 10% distilled water combination. Since it contains 60% DMSO it tends to not irritate the tissue and can be used often enough to do some good for treating PD; only rare men have trouble with skin irritation and this is solved by applying it less often. As you have learned, if the concentration is too high it cannot be used at all. It does no one any good to use a 100% concentration of DMSO but then not be able to use it. Our formula allows for repeated applications and this is where the real benefits come into play. Lastly, PMD DMSO is formulated in a gel form for easier and cleaner application since it tends to stay directly where it is applied and does not run down to create a mess.

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It is strongly recommended that before applying PMD DMSO that our Unique-E vitamin E oil and Super CP Serum (copper peptides) are applied over the area of Peyronie's plaque to increase the therapeutic benefit of using DMSO.

Of course, these three therapy products are topical applications and they should be combined with various internal therapies as described throughout the PDI website. TRH


Lack of progress with his Peyronie’s treatment plan

My Peyronie's disease  symptoms began approximately 3 years ago. I noticed a slight indentation on one side of my penis. I noticed no curvature but did experience a loss of length and girth. I immediately sought the advice of my doctor who referred me to an urologist. Over the next few months I visited three urologists; one being a reported specialist in the area of pd. All three urologist had nothing to offer. The specialist was only interested in me as a surgical candidate. Not being such a candidate, he gave me erectile dysfunction meds (which I didn't take) and sent me on my way.

I discovered your site approximately 2 1/2 years ago and first purchased your PDI handbook and Neprinol. I very soon expanded my treatment with the medium plan; adding the genesen Acutouch Pointers shortly after that. For over two years I have been taking:
Neprinol AFD 3-5 per day.
Omega "Lovaza" 4 day
PABA 500mg 1-2 day
Acetly-L-Carnitine 500mg 1-day
Vit E 400/400 1 day
Vit E Maxi Gamma 1-day
Fund. Sulfur 2-day
Quercetin Bromelain Complex 1-day (this was added within last year)
Vit C 1000 2-day
And using Pointers (daily)
PDM, DMSO Vit E castillo oil 1-2 times day

I regretfully report that I have not seen any appreciable positive change during my treatment. From your handbook, I know you say that in such a situation, I should increase dosages. You don't give specifics about increased dosages and I've been hesitant to increase the amounts of many of these treatments without guidance. I would appreciate any suggestions your may have.

I have read your handbook many times. I must admit the one difficult area of compliance is with your dietary suggestions. Could you please explain the reasons why I should never consume "cold" beverages and foods. I have not been able to find any information regarding this.

Otherwise I am very good with compliance. I have taken a few treatment breaks during my treatment; mainly to see if I noticed anything different. I did not.

Thank you for your assistance.



Shame on you for following your PDI plan for this long without asking for help until now.  You have made a great mistake to go so long without results and not contact me.  I can tell a lot of things from the way you describe your Peyronie's treatment plan, and it suggests you have not been aggressive enough with your problem.  This is your fundamental error.

Every day I communicate with men who think they are following the PDI protocol and they are not.  The one great mistake you have made for over two years that I have repeatedly warned you about is that you have blindly followed the same therapy plan over and over again without checking for changes in the size, shape, density and surface features of your PD scar. 

You say you have read my book many times, and yet you ask about the cold restriction in the suggested diet.  If you would look up this concept in any acupuncture text as I have suggested you would have the answer.  It is not my interest to teach acupuncture to people.     

We have a lot of work to do to get you going in the right direction.  But it can be done.  You have previously not been using the PDI concept correctly. First things first:  What is the size, shape, density and surface features of each of your scars?   With this information I will have an idea in which direction to increase your current plan.  It is currently very weak and needs to be increased.  TRH

Do you know a urologist in my area to diagnose a possible case of Peyronie’s disease?

I live in Portland, Oregon. I would like to get a medical diagnosis of my (possible) Peyronie's disease.   Do you have a recommended urologist in my area?


Sorry, I do not know of anyone in your area I have confidence in.    I suggest you call around to find a urologist who has been in practice for at least 25 years.  I also suggest you speak to any nurses you know for a recommendation; they always know who is good and who is to be avoided.    TRH