Is a larger single dosage better than smaller divided dosages for Peyronies treatment?

Dr Herazy,

Does taking the Peyronie's treatment at irregular intervals disrupt the efficacy of the supplements? I'm not referring to dosage.  I mean, still taking the recommended dosages per day, every single day (or whatever dosage the body needs to self correct) but, for example, instead of 2 Nattokinase twice a day, if someone took 4 of them all at once. Is this wrong? There are quite a few pills and given peoples' schedules and such, it seems unlikely they would be able to 100% of the time be able to take them right on schedule at regular intervals.

Also, when deciding to up the dosage of one of the therapies, how does one go about choosing which therapy to increase? Is it literally random, a best hunch? Or is there more of a science to choosing which one to increase?

Thanks for your time and information



Greetings A,

Thank you for the interesting question.

There are two ways of looking at what you propose in your example of taking four Nattokinase once a day instead of taking two Nattokinase twice a day.  The question is, since both methods deliver four Nattokinase to the body at the end of the day, is a larger single dosage more effective than a smaller divided dosage?

One of the methods that I suggest to men who wish to alter their Peyronies treatment dosage is to try to bundle up their dosages (especially the systemic enzymes like Neprinol, Nattokinase and Fibrozym) if the divided approach does not seem to be working as expected. 

The concept with the larger single dosage of systemic enzymes is that it would perhaps be more beneficial to flood the body with a large mass of enzymes all at once for maximum effect on fibrous scar material.  The concept of using smaller divided dosage of systemic enzymes is that it would perhaps be more beneficial to keep a relatively steady and constant application of the systemic enzymes working for maximum benefit.  Either approach could make a difference in treatment outcome and would only have to be used for a short time to determine the effectiveness. All treatment is judged by how it affects the size, shape, density and surface features of Peyronie's plaque – not what you or I think.

There is a third alternative approach that I often suggest that could be thought of as a combination of both approaches to dosage that you mentioned.   Let us say in the case of someone who is using nine Neprinol daily, it is often effective to alter the dosage during the course of the day by taking two Neprinol mid-AM, three Neprinol mid-afternoon, and four Neprinol before bedtime, since this will also flood the blood at a time when it will be most effective.  This altered approach totals to the same  nine Neprinol, but they are used so that there is a greater dosage available during the night hours when the blood is less likely to be carrying protein that might otherwise be attacked by the enzymes found in Neprinol, so they are more likely to do the good you hope for.  This strategy makes a lot of sense and often turns things around for a lot of people who are not getting the result s they want.   

Getting back to your example, I must admit that any serious Peyronie's plan usually involves use of much more than just four Nattokinase daily.  That is a relatively low dosage on the scheme of things.

Most increase of oral therapies involves working with Neprinol, Nattokinase, Fibrozym, PABA, Vitamin C, and Acetyl-L-carnitine, in that order.  

I cannot be more specific with information about what element(s) of our plan you might want to consider increasing since that is based on the specifics of the entire plan, not just looking at one small portion of it.  If you want help getting your plan in a more effective mode, contact me and we can work together.  TRH


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