November 1, 2011 Newsletter - Vitamin E and Prostate Cancer + Email exchange

November 1, 2011 Newsletter

Greetings to all PDI Warriors,

Welcome to this November 2011 PD Institute newsletter.I trust all my friends are well.

The first part of this newsletter will be a very brief comment from me added to a very interesting communication I received from the A.C. Grace Company, the manufacturer of Unique-E Vitamin E products.It is a very good answer to the recent JAMA report about vitamin E causing an increase of prostate cancer in men who take vitamin E.

I have received phone calls and emails from men and women who heard about this disturbing report, and wanted to know if they should keep vitamin E in their DCI and PDI treatment plan.If you are concerned and want an excellent explanation of this situation, you will greatly benefit from this authoritative and detailed explanation.

The second part of this newsletter will use the familiar and popular format of presenting a simple exchange and blending of emails between one of your PD brothers and me.For those of you who are part of our DCI readership, please simply apply the ideas expressed here about PD treatment and dosage to what you are doing for your DC.

Read this series of combined emails like the back-and-forth of two people talking while one occasionally interrupts the other to make an important point or answer a question.To understand the flow of the conversation, keep in mind that the text in black is from FPXXXXX and the text in red is from me.

Because we all use SPAM filters on our emails, I had to edit the content of these emails from FPXXXXXXXX before including them in this newsletter.He naturally and appropriately uses the word P_ _ _ S in several of his emails to me to discuss that part of this body.If I used that word as often as he does in a newsletter all of your SPAM filters would reject this newsletter to your junk folder. To avoid this problem, I have substituted the word SHAFT for this other word so that no one will have a problem receiving this issue of the newsletter.

FPXXXXXXXX is doing very well with his PD treatment.One of the reasons for the success of his PD treatment is that he has asked a lot of questions and pays attention to the suggestions I make.I had just answered a question of his about treatment with moist heat, when he wrote me an email telling me about the condition of his curved and distorted shaft, but said nothing about the size, shape, density or surface features of his scar.This is the point of our discussion that we will start this series of emails you will read.

Here we go, first with the Vitamin E/Prostate cancer report, followed by the email exchange:

If you are concerned about using vitamin E in your DCI and PDI treatment plan you need to carefully read this article from A.C. Grace. At the very least, read the most important section of the article written in red.Also read the helpful and interesting links at the bottom of the article.Since we do not sell the synthetic and potentially harmful alpha-tocopherol form of vitamin E, you are protected.

A.C. Grace Company

Press Release

FOR IMMEDIATE RELEASE

Vitamin E Prostate Cancer Risk Study:

What FORM of Vitamin E was used?

As you, our customers know – The FORM or TYPE of Vitamin E you take is important! That is why, since 1962, we have provided a Natural form of Vitamin E — UNIQUE E® Mixed Tocopherols (Optimum E Complex) — that is HIGH in gamma-tocopherol and includes all four tocopherol isomers (alpha, beta, gamma and
delta) in a pure form. We also provide pure UNIQUE E® Tocotrienol — high in delta-tocotrienol with NO alpha-tocopherol (which has been shown to inhibit the assimilation of tocotrienols).

The recent information concerning “Vitamin E” (alpha Tocopherol only – not the full Vitamin E complex) and prostate cancer from the SELECT study is misleading due to the use of a synthetic esterified form of alpha tocopherol as all rac-a-tocopheryl acetate. The majority of evidence points to gamma-tocopherol and the tocotrienols as the compounds of the Vitamin E complex with potential benefit for prostate cancer. You will find support of this information in the following data
(see below).

You also know that the SYNTHETIC forms of Vitamin E are nowhere near the quality or provide anywhere near the benefits of a natural form.

Why do they publish studies using low-quality synthetic forms and not the Pure, Natural form? And, why do they publish these studies in a way that appears to diminish the benefits and performance of a natural form of vitamin E?

This has been going on for decades, and will most likely continue to go on.

Help spread the TRUTH about PURE, NATURAL forms of Vitamin E.

A. C. Grace Company, and doctors all over the world, have been educating their patients and customers on the benefits provided by the natural form of Vitamin E products. We have 50 years of Doctor Tested: Application-Based ScienceTM
that helps users of UNIQUE E® Mixed Tocopherols (Optimum E Complex) and UNIQUE E® Tocotrienol understand the value of daily supplementation with the ‘right kind’ of Vitamin E and the appropriate dosage.

We ask you to share this email with your friends and colleagues. It is vitally important that people DO NOT STOP supplementing with Vitamin E! It is such an important part of our diet of which our present-day foods cannot supply, naturally, at the required levels.

Below is supporting information about Vitamin E and some links to some studies by several sources that refute the JAMA Vitamin E Study. Please feel free to review them at your leisure. If you have questions about the different types of Vitamin E available to you or your patients, please feel free to give us a call at any time.

It is important that you fully understand the ‘truth about Vitamin E!’

The A.C. Grace Company Team

800-833-4368

www.acgrace.com

Why is UNIQUE E unique?

http://acgrace.com/why-is-unique-e-unique.html

SUPPORTING DATA:

They refer to the SELECT study http://www.crab.org/select/

The bottom line

1. They used the synthetic esterified form of alpha tocopherol as all rac-α-tocopheryl acetate.

See http://jama.ama-assn.org/content/301/1/39.full

Study Design; SELECT is a phase 3 randomized, placebo-controlled trial of selenium (200 μg/d from L-selenomethionine), vitamin E (400 IU/d of all rac-α-tocopheryl acetate).

High doses of alpha-tocopherol (natural or synthetic) cause depletion of the other tocopherols and tocotrienols in the blood and the tissue.

At the heart of this mechanism is the alpha-tocopherol transfer protein which recognizes the alpha-tocopherol and preferentially puts more of it in the blood. Conclusive evidence showed that supplementation with alpha-tocopherol, especially at high levels, causes depletion of gamma-tocopherol and probably of the other tocopherols in the blood and the tissues. The major significance of this depletion on the efficacy of vitamin E received increased attention following results of major human clinical studies such as the Selenium and Vitamin E Cancer Prevention Trial (SELECT) and the Heart Outcomes Prevention Evaluation (HOPE) Study and several metaanalyses. As a result the efficacy and even
the safety of supplemental vitamin E as alpha-tocopherol were questioned. These results, coupled with increasing, research based, understanding of the role of the other tocopherols and the tocotrienols in nutrition and health, contributed to the emerging perspective on vitamin E.

2. The majority of the evidence points to gamma-tocopherol and the tocotrienols as the ones

with potential benefit for prostate cancer.

Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1128-35.

Supplemental and dietary vitamin E intakes and risk of prostate cancer in a large prospective study.

Wright ME, Weinstein SJ, Lawson KA, Albanes D, Subar AF, Dixon LB, Mouw T, Schatzkin A, Leitzmann MF.

Source

Divisions of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA. mewright@uic.edu

Abstract

Supplemental vitamin E (alpha-tocopherol) has been linked to lower prostate cancer incidence in one randomized trial and several, although not all, observational studies. The evidence regarding dietary intake of individual vitamin E isoforms and prostate cancer is limited and inconclusive, however. We prospectively examined the relations of supplemental vitamin E and dietary intakes of alpha-, beta-, gamma-, and delta- tocopherols to prostate cancer risk among 295,344 men, ages 50 to 71 years and cancer-free at enrollment in 1995 to 1996, in the NIH-AARP Diet and Health Study. At baseline, participants completed a questionnaire that captured information on diet, supplement use, and other factors. Proportional hazards models were used to estimate relative risks (RR)
and 95% confidence intervals (95% CI) of prostate cancer. During 5 years of follow-up, 10,241 incident prostate cancers were identified. Supplemental vitamin E intake was not related to prostate cancer risk (for >0-99, 100-199, 200-399, 400-799, and > or = 800 IU/d versus never use: RR, 0.97, 0.89, 1.03, 0.99, and 0.97 (95% CI, 0.87-1.07) respectively; Ptrend = 0.90). However, dietary gamma-tocopherol, the most commonly consumed form of vitamin E in the United States, was significantly inversely related to the risk of advanced prostate cancer (for highest versus lowest quintile: RR, 0.68; 95% CI, 0.56-0.84; Ptrend = 0.001). These results suggest that supplemental vitamin E does not protect against prostate cancer, but that increased consumption of gamma-tocopherol from foods is associated with a reduced risk of clinically relevant disease. The potential benefit of gamma-tocopherol for prostate cancer prevention deserves further attention.

Carcinogenesis. 2010 Apr;31(4):533-42.

Cancer-preventive activities of tocopherols and tocotrienols.

Ju J, Picinich SC, Yang Z, Zhao Y, Suh N, Kong AN, Yang CS.

Source

Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

Abstract

The cancer-preventive activity of vitamin E has been studied. Whereas some epidemiological studies have suggested a protective effect of vitamin E against cancer formation, many large-scale intervention studies with alpha-tocopherol (usually large doses) have not demonstrated a cancer-preventive effect. Studies on alpha-tocopherol in animal models also have not demonstrated robust cancer prevention effects. One possible explanation for the lack of demonstrable cancer-preventive effects is that high doses of alpha-tocopherol decrease the blood and tissue levels of delta-tocopherols. It has been suggested that gamma-tocopherol, due to its strong anti-inflammatory and other activities, may be the more effective
form of vitamin E in cancer prevention. Our recent results have demonstrated that a gamma-tocopherol-rich mixture of tocopherols inhibits colon, prostate, mammary and lung tumorigenesis in animal models, suggesting that this mixture may have a high potential for applications in the prevention of human cancer. In this review, we discuss biochemical properties of tocopherols, results of possible cancer-preventive effects in humans and animal models and possible mechanisms involved in the inhibition of carcinogenesis. Based on this information, we propose that a gamma-tocopherol-rich mixture of tocopherols is a very promising cancer-preventive agent and warrants extensive future research.

3. There is research including clinical studies supported by the National Cancer Institute

looking at gamma-tocopherol and tocotrienols and their role in cancer.

(Details available at ClinicalTrials.gov)

Vitamin E Supplements in Preventing Cancer in Patients at Risk of Prostate Cancer or Who Have Prostate Cancer

Verified on May 2011 by University of Medicine and Dentistry New Jersey

First Received on May 7, 2009. Last Updated on May 9, 2011

Sponsor:	University of Medicine and Dentistry New Jersey
Collaborator:	National Cancer Institute (NCI)
Information provided by:	University of Medicine and Dentistry New Jersey
ClinicalTrials.gov Identifier:	NCT00895115

Vitamin E δ-Tocotrienol Administered to Subjects With Resectable Pancreatic Exocrine Neoplasia

This study is currently recruiting participants.

Verified on September 2011 by H. Lee Moffitt Cancer Center and Research Institute

First Received on September 25, 2009. Last Updated on September 20, 2011

Sponsor:	H. Lee Moffitt Cancer Center and Research Institute
Collaborator:	National Cancer Institute (NCI)
Information provided by (Responsible Party):	H. Lee Moffitt Cancer Center and Research Institute ( H. Lee Moffitt Cancer Center and Research Institute )
ClinicalTrials.gov Identifier:	NCT00985777

Now for the email exchange mentioned above:

From: Dr. T. Herazy [mailto:herazy@sbcglobal.net]

Sent: Friday, October 7, 2011 6:31 AM

To: ‘FPXXXXXXXXX’

Subject: RE: Moist Heat

Greetings FXXXXXXXXX,

I must remind you that to only focus or comment on your bent penis, and say nothing about the size, shape, density and surface features of your scars does not tell me anything – and I fear you are approaching your treatment incorrectly because you only mention details about your bent shaft.The correct way to evaluate your progress is by what changes happen, or do not happen, with the scar structure.

Please see below for additional comments…

From: FPXXXXXX

Sent: Tuesday, October 11, 2011 2:09 PM

To: Dr. T. Herazy

Subject: Re: Moist Heat

Greeting, Dr Herazy

Did you check this email? What can you tell me about the pelvic massage?

Regards,

FPXXXXXX

2011/10/7 FPXXXXXX

Hi Dr Herazy, thank you for your previous answers.

Yes, I understand that I have to evaluate my scar in many other aspects. I tried a lot of times, but I can’t find any different tissue. What I mean is that the only thing I felt, in the place where the magnetic resonance image showed a scar before, now seems a lot with other parts of my shaft. Are you massaging the shaft directly?If so, please stop since this might harm you. What part of your body are you evaluating? I asked for my girlfriend’s help and she felt something different, so I’ll ask her to help me to evaluate it in details. Also, there is a scar that is under my pelvic bone, so, it seems that is not possible to evaluate this one.

Anyway, it is a big deal for me that I am able to make love again, since the pain eased down. Only I didn’t see any improvement in the curve. You should not be concerned with the curve, but with the scar. What have you noticed about the size, shape, density and surface features of your scar?

About the tissue massage, you say in the book that “When you locate an area of contracted and tight tissue, you will note that the same fingertip pressure that was nicely comfortable in other neighboring tissue of the pelvis will suddenly cause discomfort you did not feel in other areas”.

What I’m telling is that I do the massage but never feel any pain, like there was such points which I should be looking for and working on.Yes, the only areas and points of tissue you should really be concerned about and massaging are those that are painful to a light or gentle touch.You should not have to press or work very hard to feel this kind of discomfort.The tissue that you should be concerned with will be unusually sensitive to touch; your same light touch will not cause pain in all general areas you are looking but will only cause discomfort in a few spots; those are the areas to work with.If you are having trouble with this just look at the Massage and Exercise video again.TRHI can keep doing the general massage if
it is worth it.

Regards

FXXXXXXXXXXX
2011/10/7 Dr. T. Herazy <herazy@sbcglobal.net>

2011/10/12 Dr. T. Herazy <herazy@sbcglobal.net>

See below for my comments to your email…

Regards,

Theodore Herazy, DC, LAc

Peyronie’s Disease Institute

Dupuytren’s Contracture Institute

Em quarta-feira, 12 de outubro de 2011, FPXXXXXX

escreveu:

Greetings, Dr Herazy,

As I said, I find it really difficult to locate the scar because I always find that the part of the shaftwhich seems to be the scar looks like many other parts as well.

About the tissue massage, I am massaging the pelvis, as you explain in the book and video, not the shaft. and I don’t feel pain in any area of contracted and tight tissue.

Regards

FXXXXXXXXX

From: FPXXXXXX

Sent: Tuesday, October 18, 2011 12:25 PM

To: Dr. T. Herazy

Subject: Re: Moist Heat

Greetings, Dr Herazy.

Remember this email? I told you that me and my girlfriend weren´t able to find the scar. As I told you, every time that I found some surface that seemed to be different, I realized that in other parts of the shaft were like that.

Well, I saw the urologist that first told me about the PD one year ago. I asked him for some help to find the scar so I could monitor it. It happened that the urology doctor couldn´t find the scar either. He told me that in his notes he has found a plaque at that time in my shaft when he first examined me. But now he had the same impression I had: that he couldn´t tell for sure what could be a scar or what was some vein (he used a specific name for those veins that I can´t remember right now).

The curvature remains, the pains is getting better. I had an exam that showed one of the plaques under the pelvic bone. This scar I can´t find or monitor. Maybe is this one that is still causing the curvature? If it is correct, maybe the other one is gone and so I should continue the treatment I am doing right now, take the same medicine.

Well, I would like to hear your opinion on that.

Regards

FXXXXXXXXXX

Em terça-feira, 18 de outubro de 2011, Dr. T. Herazy<herazy@sbcglobal.net> escreveu:

Greetings FXXXXXXXXX,

As I understand your report, you are saying that the urologist who first found your scar a year ago cannot find it now in that same location. That is great news.

My educated guess is that there is still enough reduced or smaller scar that cannot be felt, yet it is still large enough to cause some of the curvature you are still able to see. My further educated guess is that the curvature is also reduced and you would know it is reduced if you had spent some time measuring or drawing it out before you started your PDI treatment. These things can be extremely difficult to remember for sure once the changes begin to occur.

I suggest that you continue to follow your plan in the hopes that your scar continues to reduce and your curve does the same.

Regards,

Theodore Herazy, DC, LAc

Peyronie’s Disease Institute

Dupuytren’s Contracture Institute

From: Dr. T. Herazy [mailto:herazy@sbcglobal.net]

Sent: Wednesday, October 26, 2011 6:31 AM

To: ‘FPXXXXXXXXX’

Subject: RE: Moist Heat

Greetings again FXXXXXXXXX,

Sorry for the delayed response; your last email got lost in a large group of emails that arrived at the same time.

See below for comments…

Regards,

Theodore Herazy, DC, LAc

Peyronie’s Disease Institute

Dupuytren’s Contracture Institute

From: FPXXXXXX

Sent: Thursday, October 20, 2011 2:06 PM

To: Dr. T. Herazy

Subject: Re: Moist Heat

Greetings, Dr Herazy!

This is great news indeed about the doctor not being able to find the scar that he felt before! Hope your guess is right.

I was using only nattokinase and fibrozym till now, I just got into neprinol. Since the results I achieved were with the other 2 enzymes, I wonder if I should continue that. Using the Neprinol by itself or in combination with Nattokinase and Fibrozym is something you can experiment with. Men use Neprinol both ways – as a total substitute for the other enzyme products, or in addition to them (usually with the Neprinol being the primary enzyme source and the others being used as a minor role). The choice is yours. Do it both ways for a month or so and see what happens to your scar and your curve. When I successfully treated my own scars that is what I did – I used the Neprinol as the primary and largest supply of systemic enzymes, and then added in a few of the others per day.

I suggest you consider first trying just the Neprinol by itself, and see how it works for you and your scar. If that is not enough to keep your scar to change favorably, then bring back the Fibrozym or Nattokinase, or perhaps you could consider also increasing Quercetin/Bromelain if you think it is necessary, or all of them. You must keep experimenting to learn what makes your scar, or your curvature if you no longer can locate your scar, respond favorably and then continue with that.

I am also using Quercetin and Acetyl. I am taking acetyl with food and the quercetin with the enzymes.

The Quercetin also contains lots of vitamin C. May I decrease the Vitamin C alone to 1 capsule a day? In my opinion, the Quercetin-Bromelain product does not contain “lots” of vitamin C; I think it is a small amount when you consider we always think in terms of larger therapeutic dosages. This particular product is not about supplying a large amount of vitamin C.It contains only what is referred to as a synergistic amount – just enough vitamin C to allow the primary nutrients to function chemically when taken into the body.How much vitamin C you actually take is, as always, your decision.Keep in mind that the amount of vitamin C in Quercetin Bromelain is 200mg per capsule. All of the standard vitamin C capsules themselves contain 1000mg per capsule. Since I see that you
are taking six Quercetin Bromelain capsules daily (containing a total of 1200mg of vitamin C) that means you are taking just a little more than the equivalent of one vitamin C capsule daily when you take these six Quercetin Bromelain capsules – this is not very much vitamin C when compared to what most men take. From what I know most men take 3-6 capsules of 1000mg of vitamin C, or 3000-6000mg of vitamin C, along with any other vitamin C that might be contained in other therapy products. This is what others do; you have to see how your body responds. You might not be able to tolerate that much of the standard vitamin C. If this is so, you should definitely use the buffered form of vitamin C called Ascorbplex 1000 that will not bother your stomach lining.

I would appreciate if you take a look at my schedule and give me your opinion:

Morning, around 7:00 am: 2 Neprinol, 2 Quercetin, 1 Fundamental Súlfur

(Is this all right, taking all the in between meals capsules at one time?) Yes; no need to separate those.

Breakfast, around 9:00 pm: Colchicine and Vitamin E 400

Lunch, around 12:00 pm: Colchicine, Vitamin C and Vitamin E Maxi Gamma

Between meals, around 5:00 pm: 2 Neprinol, 2 Quercetin, 1 Fundamental Súlfur

Dinner, around 7:30pm: Colchicine and Vitamin E 400

Before sleep, 2 hours after dinner: 2 Neprinol (to increase after 1 week till 5), 2 Nattokinase and 2 Fibrozym, 2 Quercetin, 1 Fundamental Sulfur

As you see, I kept the Nattokinase and the Fibrozym at night before sleep, and I am also willing to increase the Neprinol till 5 capsules at that time.

What I think about your plan is not important. The important thing is how your plan affects the size, shape, density and surface features of your scar. If this plan you are using – which looks good to me – is helping you to reduce your scar to the point that your MD cannot find it any longer, then this is the plan you should use. If you find that after time the scar or the curve stop changing, then you will have to decide how to modify your plan so that your favorable tissue changes continue to occur. We can work on that later if it becomes necessary. TRH

Regards

FXXXXXXXXXXXX

That for now is the conclusion of this discussion with FPXXXXXXXXXXX. I hope you all were able to benefit from this exchange of information.In particular I hope everyone noticed how he is using his plan and how he is modifying it carefully to assure his best therapy results.

Let me know if you have any questions about what you are doing.Stay focused to your treatment.

Regards,

Theodore R. Herazy, DC, LAc