L-Arginine for Peyronie's disease treatment is based on its ability to increase NOS levels in the blood, which has an anti-fibrotic effect. The use of L-arginine for Peyronie’s disease has been a relatively recent discovery.  More and more I hear from men whose doctors encourage the use of L-arginine use for PD because of the encouraging research science behind it.

Lawrence Levine, MD, a urologist who is widely thought by some to be one of the leading PD authorities in the world advocates for the use of L-arginine.   He states that his experience using L-arginine  with his PD patients has been good.

This use of L-arginine as a Peyronie’s treatment is recommended because it stimulates NOS activity and hence NO synthesis, which in turn can inhibit collagen development and reduce the development of fibrous tissue elements in the body, thus acting as a anti-fibrotic agent. This supports the hypothesis that the increase in NO may be effective in reversing the fibrosis of Peyronie’s disease.

The usual suggested dosage of L-arginine is 500 mg., twice daily, for a total of 1,000 mg.


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