Peyronie’s and Verapamil

Verapamil and Peyronie's disease treatment

Verapamil is used in Peyronie’s disease treatment by injection directly into the Peyronie’s plaque or a topical Verapamil cream is applied to the skin over the Peyronie’s plaque.   For more information about this method, see Peyronie's disease treatment via direct drug injection.

Verapamil is a calcium channel blocker of the phenylalkylamine L-type.  It works by relaxing the muscles of the heart and blood vessels. Verapamil is an anti-arrhythmic drug approved by the FDA in 1981 to treat hypertension, angina, cardiac arrhythmia, and recently, cluster headaches.  No oral or transdermal Verapamil is approved for Peyronie’s disease treatment.  Most used for Peyronie’s treatment is in the form of a topical Verapamil cream that is applied twice daily for many months.

There are many different companies that compete against each other with their own unique patented Verapamil formula, creating difficulty to know what to believe about the use of Verapamil for Peyronie’s disease treatment.

With so much competition among companies and unsafe practices of illegal companies, some even resort to making inferior and dangerous topical Verapamil cream products.  As a result, Peyronie’s patients who use counterfeit Verapamil have reported:

  • Changes in blood pressure, causing dizziness, fainting, heart beat irregularities, often requiring changes in other medications to become stabilized
  • Severe skin irritation
  • Skin burns and blistering

Peyronie’s Verapamil connection

As with many popular medications, the exact way Verapamil is supposed to benefit Peyronie's disease is not entirely known.  Keep this in mind when someone says they do not know how vitamin E or acetyl-L-carnitine or PABA helps Peyronie’s disease.

It is proposed that long term use of Verapamil blocks calcium from entering into the Peyronie’s plaque or scar.  Another theory s that Verapamil increases fibroblast activity to make more collagenase that breaks down the Peyronie’s plaque or scar. However, calcium is an essential mineral that must have free access and movement in all tissues and hundreds of different normal and healthy chemical, enzyme and hormone functions of the body.  The body needs calcium to function normally and healthfully, and it does not do well when it is blocked by a drug like Verapamil.

Peyronie's disease and Verapamil side effects

When taken topically or orally for Peyronie’s, Verapamil can cause side effects that may impair thinking or abnormal organ function because of calcium metabolism interference.   Care should be used when driving a car, operating dangerous equipment, or any skill in which mental alertness or memory is needed.

Verapamil and Peyronie's disease warning

Men treating Peyronie’s disease with Verapamil must deal with extreme fatigue, loss of energy, blood pressure problems and skin reactions that often occur.  Also, if Verapamil is stopped suddenly any side effect or problem for which it is being taken (like Peyronies) may become worse.

You should not use Verapamil if you are allergic to it, or if you have:

  • Serious heart conditions, especially "sick sinus syndrome" or "AV block" (unless you have a pacemaker)
  • Low blood pressure
  • Recent heart attack

Personal experience with Verapamil and Peyronie's disease

After attempting to treat my own Peyronie’s disease with topical Verapamil cream for eight months, my overall health suffered from weakness, fatigue, memory failure and low blood pressure caused by the Verapamil in my blood stream.  However, worst of all, while using Verapamil my Peyronie’s disease worsened.   The size of each Peyronie’s plaque increased and my Peyronie’s curve doubled.

Shortly after using Alternative Medicine to eliminate my Peyronie’s problem, I started the Peyronie’s Disease Institute with my MD colleagues I was working with at the time.  With this organization I communicate with dozens of men daily about their problems with PD.  Considering the information outlined above, it seems fewer and fewer medical doctors use Verapamil for Peyronie’s disease management.

Dr.Herazy

2 thoughts on “Peyronie’s and Verapamil

  1. Dan Cook says:

    I have been diagnosed with Peryonie’s Disease and have recently seen a urologist. During our discussion he wrote a list of several options I could research as I didn’t want to make an immedient decision on a treatment and I didn’t know too much about the disease. My internet search has left me with more Peyronie’s disease questions than answers and I still don’t know how to procede before my next appointment with the doctor.

    The deformity in my penis started about a year ago and it is now pointing nearly 90 degrees up when erect but not as painful as it once was. I have been trying the recommended vitamin E and Actyl L Carnitin along with L arginine and Saw Palmetto with no success. I am cautious about what I read on websites about Peyronie’s disease but your information sounded good so I would like to know your recommendations.

    Thank you in advance for your help,

    Dan Cook

  2. Dr.Herazy says:

    Greetings Dan,

    Thank you for your kind comments about your experience with Peyronie’s disease.

    Simply “taking” vitamin E, acetyl-L-carnitine and L-arginine for your Peyronie’s disease is not the way it is done. It is necessary that they be combined with other standard nutrients you find on the PDI website in the correct dosages, and in the correct way. In addition to nutrients that are taken internally, we have found great benefit in combining them with several external therapies that are also helpful. These dosages must all be slowly increased over time. How all of this is done and how these broad combinations are created is explained in detailed information that is provided to you when you place your first order with PDI. Nearly 20 pages of notes are included with orders so that all PDI customers are told how to use whatever products they order.

    By the way, I have not learned how saw palmetto might be helpful in treating Peyronie’s disease. TRH

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