Peyronie’s Disease Treatment Via Direct Drug Injection

Injections can cause Peyronie’s disease

Peyronie’s disease treatment using drug injection into the delicate tunica albuginea of the penis is a medical therapy that is fast loosing favor for treatment of the Peyronie's penis.  One of the reasons is the lack of good results, the other is that it has been shown that injections can cause or aggravate Peyronie’s disease in many cases.

I have personally communicated with hundreds of men whose Peyronies started after a series of penile injections that were undertaken for a variety of reasons.  It appears the drug is not so much the issue that causes injury to the tunica membrane, but the repeated penetration and trauma that causes the scar material that eventually starts a Peyronies problem.   However, it has also been shown that the presence of certain drugs can cause a chemical irritation to the tunica albuginea.  So in this regard, drug injections could easily represent a double threat of injury to the tunica that results in Peyronie’s disease.

Peyronie's treatment – "First, do no harm"

This blog post about Peyronie’s disease treatment using direct drug injections (Verapamil, cortisone, etc.) should hit home for a large number of you.  Many men have undergone painful drug injections into the penis because their medical doctor thought it was worth the effort, and only found themselves with a new problem or worsening of their original Peyronie's disease.

First I will simply copy an article, “Extracorporeal shock-wave therapy in the treatment of Peyronie's disease.”  This research discussion is essentially about Extracorporeal Shock Wave Therapy, ESWT (or ESWLas they call it here).  

What is important to note in our particular discussion is the area I have highlighted for emphasis.  This form of therapy has been fairly well abandoned by a large percent of doctors who used it for many years since these injections seem to cause more problems than it helps. The reason this information about ESWT (or ESWL) is included in this article about penile injections is that these Russian physicians make a very interesting comment while discussing ESWT that underscores the damage created by injections (of any kind) into the tunica albuginea.

[Article in Russian]

Ne?mark AI, Astakhov IuI, Sidor MV.

The authors analyse the results of treatment of 28 patients with Peyronie's disease using extracorporeal shock-wave lithotripsy (ESWL) performed on Dornier U15 lithotriptor. A total of 2-6 sessions were made, maximal number–12. The efficacy was controlled by clinical indices and ultrasonic investigation (Doppler mapping of the blood flow). ESWL proved to be efficient in the treatment of Peyronie's disease (PD), primarily, in patients with early disease before appearance of severe fibroplastic alterations. Less plaque vascularization by energetic Doppler mapping due to ESWL is an important diagnostic criterion of PD treatment efficacy. Conservative treatment is not indicated in marked deformities and plaque calcification, erectile dysfunction. Moreover, any injection into the tunica albuginea, especially complicated by hematomas (deep tissue bruising) may be a damaging factor which triggers fibrous inflammation. Such patients should be treated surgically. If the patient is interested in immediate results or is not interested in continuation of sexual life, the treatment is ineffective. Thus, ESWL is an effective, safe method of PD treatment but requires further study and accumulation of clinical experience.

It seems that the problems penile injections can cause is not that necessarily about the drug that is injected into the tunica, but the needle itself that is used to deliver the drug. An injection to deliver any drug, or sterile water, can cause injury to this delicate membrane.  This sets off an inflammatory response that can result in significant Peyronie’s disease plaque or scar tissue formation for men who as so predisposed.   Doing this once can be risky.  Doing this up to a dozen times over a few months, as is often the recommended course of therapy, just multiples the opportunity for injury to mount on top of injury.

This Russian research team offers the opinion that the effects of such injection into the penile shaft causes such significant plaque development, that surgery is the best treatment option for the damage that it can cause.   Obviously, I do not agree with that, since surgery can also cause more scar development. Their conclusion is that they find men who receive these injections often eventually are rewarded with a disturbed and discontinued sexual life.

Growing concern about injections for Peyronie's disease treatment

This idea is brought to your attention to demonstrate there are many in the medical community who agree with the same position that I have taken for many years now.  These doctors and I contend it is inherently risky, in fact, dangerous, to stick needles repeatedly into the penis for Peyronie’s disease treatment. Their  logic concludes that any treatment that can start or aggravate the very problem it is attempting to treat, is not much of a treatment.

It is unfortunate that the medical community turns a blind eye to the direct observation of poor results, serious irritation of the tunica, and the solid logic that reputes injections as a form of Peyronie’s cure.  Those who continue to inject their Peyronie’s disease patients, and bring these men farther down the road toward greater plaque development, must be desperate to look useful or just ignorant of how Peyronie’s disease often develops.  It is so common for medical doctors to think only in terms of medicine and surgery, notwithstanding the tragedy that can often result from their limited thinking.

The Peyronie's treatment concept of using non-invasive methods to increase the healing response of the body is a safer and more trustworthy Peyronie’s disease treatment than some of the aggressive medial schemes being promoted today.


8 thoughts on “Peyronie’s Disease Treatment Via Direct Drug Injection

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  5. Rich krausen says:

    My comment is after seeing my doctor for my Peyronie’s disease, she prescribed a verapamil ointment from pd labs in San Antonio Tx. I read all their brochures sent from them. So far I have been using the ointment for 3 months. After the first month the pain associated with intercourse became better. The curvature hasn’t improved much and like you said we all are looking for a fix all quickly. The problem I have run into is the insurance company will not pay for the medicine because they say that pd labs is not an a credited pharmacy. If this gel being dispensed from pd labs is as positive as the brochures say it is, why haven’t I heard more men using it?, why is my insurance company refusing to help in the cost of the medicine? Have you heard any positive outcomes for Peyronie’s disease from a verapamil gel? I would hate to have given this company all this money for a 9 month treatment and after the 9 months be at square 1 again! Thank you for any help you can provide.

  6. therazy says:

    Greetings Rick,

    When I first developed Peyronie’s disease back in 2001 I also used topical verapamil from PD Labs in Texas. After three months of faithful use my Peyronie’s disease was clearly worse, and I was suffering from side effects so bad (dizziness, fatigue, light headed, blurred vision, headaches) that I could not drive, and work was very difficult. At this point I realized that traditional medicine had nothing to offer me – or anyone with Peyronie’s disease – so I started to do the research with three MDs that I was practicing with at the time. As a result of our work, with me as a very willing guinea pig, my PD started to improve. From this original work and the later discoveries I have made, came the Peyronie’s disease information you see on the PDI website.

    I have not run into many men who say that verapamil, as a pill, shot or cream has helped them. I cannot make any comment about the claims made by the people at PD Labs.

    You might want to read about the ideas of using Alternative Medicine to treat Peyronie’s disease presented on the PDI website. See if it makes sense to you, and then decice what you should do. TRH

  7. Theodore Herazy says:

    Greetings Vincent,

    No, it is not safe, in my opinion. It is not so much the Trimix drug that is the problem, but the need to deliver a high number of injections into the delicate tissue of the penis that causes the problems. All experts agree that physical injury of the penis is the main cause of Peyronie’s disease. Making dozens of injections into that same tissue area can easily cause or aggravate PD.

    As you can read in the first paragraph of the attached article, “Peyronie’s disease treatment using drug injection into the delicate tunica albuginea of the penis is a medical therapy that is fast loosing favor for treatment of the Peyronie’s penis.  One of the reasons is the lack of good results, the other is that it has been shown that injections can cause or aggravate Peyronie’s disease in many cases.”

    Treating the penis like it was a pin cushion is a good way to develop or worsen Peyronie’s disease. TRH

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