Peyronie's disease plaque and fibrin
The tissue changes that occur in Peyronie’s disease are unique in regard to the Peyronie's plaque that develops.
In a November 2005 abstract account, Kenneth D. Somers and Dawn M. Dawson, of the Department of Microbiology and Immunology, Eastern Virginia Medical School, Norfolk, Virginia, and Department of Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, reported on their findings concerning the tissue changes that occur in Peyronie’s disease.
To begin this explanation, they remind us that Peyronie's disease is actually a pathological fibrosis, or a situation in which there is excess fibrin tissue located in a small area to the degree that it becomes a problem for the body. In the case of Peyronie’s disease, this fibrosis also is associated with an excessive deposit of collagen in the same area of the fibrin plaque or scar.
Although the cause of Peyronie's disease remains unknown, they tell us, injury or trauma has long been thought to be the inciting event. To determine if this is true, they looked at the cellular structure of the Peyronie’s plaque or scar to get an insight into the cause of this condition.
Materials and methods they used
Small samples of plaque tissue was taken from 33 patients with Peyronie's disease, and control tissue and nodular tissue was taken from the penis of eight patients with Dupuytren's contracture; both groups of tissue were analyzed for collagen staining, as well as fibrin and elastic fiber structure and distribution.
As a result of this study they found abnormally stained collagen in 97% of the samples, disrupted elastic fibers in 94% and excess fibrin deposition in 95% of the samples. These same findings were not found in the normal scared tunica albuginea of control patients who did not have Peyronie’s disease. The presence of abnormal fibrin accumulation in Peyronies plaque tissue was detected in a special chemical analysis, while this abnormal fibrin was not found in skin tissue samples from the same patients.
Their conclusions from this study is that the fibrin deposits in Peyronies plaque tissue is consistent with the theory that repeated minor injury or single major injury to the tunica albuginea results in fibrin being deposited in the tissue spaces at the site of trauma to start this condition.
PDI therapy concept
Peyronie’s Disease Institute has taken the position that it is this excess fibrin deposit within the excess collagen formation that can be safely and easily removed by the use of a battery of systemic enzymes that are specific for foreign fibrin protein in the body. By using natural Peyronie's disease treatment methods to increase the healing response of the immune system against Peyronie’s disease plaque, it is possible to reverse the abnormal tissue found in the tunica albuginea and therefore eliminate the cause of pain and penile curvature associated with Peyronie’s disease.