Do you know of any link between Peyronie's disease and PSA (Prostate-Specific Antigen)?

My question is, do you know of any link between Peyronie's disease and PSA?

Since I acquired Peyronies, my PSA has increased over a couple of years.


Greetings Dave,

In my opinion there is a possible link between an elevated PSA test and Peyronie's disease, actually two links, but only in an indirect way and probably not as you might expect.  I will discuss that association a bit later after a few preliminary remarks so all readers can be more familiar with the PSA test.

Every man needs to know that PSA (prostate-specific antigen) is a protein made by normal prostate gland tissue in the adult male.  A recent ejaculation, any inflammation of the prostate whether caused by  acute injury, benign (non-cancerous) enlargement (BPH or benign prostatic hyperplasia) associated with aging, or prostate cancer can elevate the PSA level found in the blood.

In the mid-80s the PSA test was approved by the FDA only to monitor the progression of prostate cancer that was previously diagnosed.  In the mid-90s the PSA test was approved by the Food and Drug Administration (FDA) to be used in conjunction with a direct digital rectal examination (DRE) to annually test men who did not have active prostate symptoms as a screening procedure for prostate cancer. 

However, due to recently becoming aware of the limitations of the PSA test and the potential harm that can arise with its use, it the FDA acknowledges the PSA test is not a dependable prostate cancer screening procedure; it yields a false-positive result in about 75% of positive tests (only one correct test result out of four positive tests) . This means that three men who do not have prostate cancer will receive an incorrect test result for every four positive tests.  Prostate biopsy operations are performed on a routine basis when a PSA test is positive, so this means that three out of four prostate biopsies are unnecessary and expose those men to unnecessary risks and side effects.

On the other side of the coin, a false-negative PSA test can also come back with a low or normal readying even thought active prostate cancer is present.  This does not happen nearly as often as a false-positive PSA test, but it does occur, giving a man and his doctor, as well as his family, a false sense of security that cancer is not present when in fact he might have prostate cancer that requires immediate treatment.

As a cancer screening test the PSA, when it is actually correct,  can help detect the presence of small cancers that do not cause symptoms.  However, simply locating a small prostate cancer does not result in a man living longer.   Several types of prostate cancer detected by PSA testing grow so slowly they are unlikely to be a cause of death.  Further, detecting cancer early might not help a man survive a fast-growing or aggressive tumor that often spreads to other tissues and parts of the body long before it is detected.   For this reason the FDA now takes a different position about the PSA detecting prostate tumors:  early detection of slow growing and non-malignant prostate tumors that do not threaten a man’s life can result in “overtreatment” of low-threat problems, and this routine screening use of the PSA test has been called “overdiagnosis.”

Active and aggressive treatment of a low threat and slow growing prostate cancer is called overtreatment because the side effects and complications that arise from this kind of cancer treatment are often far worse and more life threatening than the cancer itself.   Beginning with  suppression or weakening of the immune system that makes a man more susceptible to infection anywhere in the body and other diseases, urinary incontinence (inability to control urine flow), bowel and urinary dysfunction and erectile dysfunction are a common side effect of cancer treatment.

More commonly now only those men who report actual prostate symptoms will be given a PSA test along with a digital prostate examination to determine the cause of their symptoms. The exception to this more limited use of the PSA test is for those men who are who are at greater risk of malignant prostate cancer (black men or those men whose father or brother had prostate cancer).  For this group it is recommended that they begin to screen for prostate cancer in their mid-40s.

For these men in a high risk group, PSA testing spread out over a period of several years rather than several months gives the most accurate and revealing diagnostic information. One individual elevated PSA test may be a reason for only mild concern, because often the next PSA test will be normal.  But a series of slowly raising PSA tests over a period of a few years is another matter and warrants further prostate testing. 

PSA testing is also controversial for men 75 years old and above.  This age group is far more likely to have a slow growing cancer.  This type of cancer posses very little immediate health risk compared to the other cancers, heart, lung and kidney diseases, diabetes, degenerative neurological and vascular disease (that often occur as multiple health problems) in the elderly.  For this reason PSA screening is not recommended for elderly men with multiple health problems or a single major medical problem, or when life expectancy is less than 10 years.

So now, Dave, with all that on the table, allow me to offer my thoughts about a possible connection between Peyronie's disease and the PSA test. 

When a man has a PSA test and the results come back positive, the doctor treating doctor will do additional tests that will probably include a prostate biopsy.  After the prostate biopsy the man might be catheterized (a thin catheter tube inserted up his urethra – the urinary passage in the penis) to help him void urine. I have written in the past about the issue of abusive catheterization leading to PD in  Possible Peyronie's cause: Catheter and cystoscope trauma. In this sense, men who have had a PSA test can develop Peyronie's disease indirectly as part of the process of having their prostate gland treated.

As a second possible link of PSA tests and Peyronie's disease, please consider the man who goes to his medical doctor for symptoms of prostate enlargement (urinary frequency, urinary dribbling, difficulty starting or stopping the flow urine or pelvic and penis pain).  As these things often progress, this man could be given a PSA test to assess the condition of the prostate and subsequently be prescribed the drug Proscar (finasteride) to reduce prostate enlargement (benign prostate hyperplasia – BPH).   There are a growing number of lawsuits now pending which claim that Proscar can cause Peyronie's disease; for additional information please see Will the drug finasteride (Proscar) (Propecia) affect my Peyronie's disease in any way?

I would be interested to learn more about your situation, Dave.  In particular, if you have ever taken Proscar in relation to prostate enlargement; and if have, if your Proscar was taken before you knew you had PD.  Now that you have Peyronie's disease I believe there is no direct connection between your prostate gland or Peyronie's disease and the raising pattern of your PSA readings.     

For additional information please see Prostate screening and Peyronie's disease.   TRH

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Aneros purchase guide for Prostate Massage

Prostate milking for BPH, enlarged prostate and prostatitis

Deciding which Aneros model to choose is easier when you remember that they are all designed to do the same two things – prostatic massage and orgasm pleasure enhancement – but one model may be more effective than another because of overall body size, prostate size and shape, strength of PD muscles and ability to control contractions, pelvic contours, ability to relax during Aneros use, etc.   In this way the Aneros provides a wonderfully therapeutic prostate milking massage that greatly helps recovery from BPH and chronic prostatitis, as well as reduction of prostate symptoms  in men over 40.

All five Aneros prostate massager devices rely upon a patented, hands-free design that uses the contraction of the anal muscles to control the prostate massage in a controlled, safe and pleasant action.  While each model has the same general design idea, close inspection shows each has its own unique shape and size that determines how it performs.  Some are slightly larger, and some have more subtle curves here and there.

Click here to purchase an Aneros prostatic massager – scroll down to the bottom of the page for the Aneros devices.

It is important to understand that each Aneros unit – Helix, MGX, SGX, Maximus and Eupho – works the way it does because of its overall design, not just because of one characteristic.  Size is not the most important characteristic of any one unit (bigger is not necessarily better), nor is shape.   Each model will be described and general comments will be offered about the performance quality of each.  With this information you can develop an idea which mode will work well for you.

It can be safely said that most men can use most Aneros prostate massagers; one or two might feel more comfortable than one or two others, but most models could be used with no problem.  There are no strict rules that dictate which model would suit a man better than another.  The idea that there is a “best” model of Aneros is not generally true.  The idea that there is a model you prefer more than others – your “favorite” – because its subtle difference fits your body better than others is closer to the truth of it.

To massage the prostate well, improve pelvic muscle tone

The Aneros will work better as a prostate massager if the lower pelvic PC muscles are strong and can be controlled well to push the device against the prostate. If you feel nothing happening when you have your prostate massager in place, it will be because your pelvic muscles are not strong enough; with continued use you will begin to feel a pleasant and sexual feeling during use that will tell you that you are getting stronger. The more you use the Aneros, regardless of which model you select, the better the prostate massage and sexual stimulation will be.  Continued use and practice pays off over time, as you learn how your body reacts to the Aneros depending on body posture while using it, comfort level and your mindset.

Read about each model before making a decision.

Aneros MGX – for beginner and all men       Aneros MGX

The Aneros MGX is a medically researched and designed to slide and rock over the surface of the prostate gland as the anal sphincter muscles slowly contract and relax.  The MGX is well balanced with a ribbed stem for prostate stimulation and stability

It is designed to stimulate both the prostate and the perineum in a rhythmic motion that moves lymphatic fluid out of the prostate as well as increase blood flow in this region, thus assisting the natural healing ability of the body, as well as creates male orgasms.  It has a standard ample perineum tab to provide an external prostate massage through the perineum.

A good choice for the novice and a favorite of the advanced user, with continued use and improved muscle action it provides a progressively great prostate massage.
•  For beginning and experienced users
•  Ribbed stem
•  Standard perineum tab
•  Polished to hold lubricant for better movement
•  Sue Johanson's Top 10 Toys of 2003
•  One of Playgirl Magazine sex columnist's two favorite toys for men.

All Aneros models are made in the USA from FDA approved materials.

Aneros SGX for beginner and all men, especially those men shorter than 5’6”    Aneros SGX

The SGX is the smallest Aneros model, originally developed for the Asian market and geared toward men 5’6” and shorter.  The insertion length of the SGX measures approximately 1/2 inch shorter ( a total of 3½ inches) than the MGX.  So do not be fooled to think that there is a huge sixe difference in these units.  Even so, its smaller size makes for easier insertion and use, and progressively rewarding symptom relief and improved sexual experiences.

However, this smaller unit might be a good starter model for those men who want to be conservative due to apprehensive about prostate stimulation.

Do not be confused about size of the different Aneros units.  Many times it happens that a short and smallish man prefers a larger Aneros device and a tall and large man prefers a smaller Aneros unit like the SGX; all size men can use all size Aneros massagers.  Ability to relax the anal muscles probably has more to do with the size of the device that a man will prefer to use.

The Aneros SGX is for men of all experience levels.   Men who receive good results from the SGX sometimes try a slightly larger model to see if their positive results might not increase.

The Aneros SGX, like its cousin the MGX, has a balanced head and ribbed stem with a thick, standard perineum tab.

• Great for prostate health, especially BPH
• For beginning users
• Smaller cousin of the MGX
• Ribbed stem for stability
• Standard perineum tab

Aneros Helix – for beginner and all men; tends to be the most effective model for prostate massage for most men        Aneros Helix

The best-selling Aneros Helix is part of the Next-Generation line (includes the Maximus and Eupho models.)  The Helix is aggressively shaped and angled, providing immediate pressure and tension on the prostate and surrounding area. It has a large, bulbous head and thin-angled stem for greater pivoting action. The tip of the head is also flatter, offering the most direct contact on the prostate, resulting in a more "aggressive" or vigorous prostate massage.

The Helix was designed based on research studies and user feedback surveys, and earned several additional design patents.  In terms of dimensions, the Helix is larger at the tip (1 1/16" versus 7/8 " on the MGX) and is more angled to provide a more vigorous massage. However, the mid-ridge is slightly smaller (1/16" smaller) on the Helix.  The redesigned P-Tab provides a more focused external prostate stimulation when massaging the perineum.

• For adventurous beginners and advanced users
• Next generation model
• Larger bulbous head with flat, wide head for more contact with prostate
• Strong angled stem for greater pivoting ability
• Dime perineum tab

Click here to purchase an Aneros prostatic massager – scroll down to the bottom of the page for the Aneros devices

Aneros Maximus – for Intermediate to advanced users       
Aneros Maximus

The Aneros Maximus is definitely true to its name.  It has a larger contact head, larger stem, and thick, standard perineum tab.  It is recommended for the advanced Aneros user and for men experienced with anal play, and is popular in the gay community.   The Maximus is similar in shape to the MGX and SGX, but expanded throughout.

The Maximus is part of Next-Generation line which includes the Helix and Eupho.  Its size makes it more difficult to insert and moves less than the other models.  Experienced Aneros users will have higher developed PC muscles, which makes it easier for the Maximus to move.  It provides greater pressure throughout the rectum and this makes it slightly more difficult to insert due to its size.  The Maximus has been reported to be a great performer during traditional intercourse.  Therefore we recommend the Maximus for men who are experienced with anal and prostate stimulation.

• Next-Generation Model
• Largest Next-Generation model
• Extra girth provides more anal canal stimulation
• Requires stronger PC sphincter muscles
• Great for prostate health

Aneros Eupho – for Advanced users       
Aneros Eupho

The delicately shaped Aneros Eupho is the most advanced model, at least based on the most number of patents it holds. It is recommended only for advanced Aneros users. It is proportionally the longest and slimmest model. It has a dime-style perineum tab and extremely thin head. These design features allow for the greatest movement of all Anderos models.  Therefore, the Eupho user must have highly developed PC muscles to control its movement. The thin head will “skip and dance” around the prostate during use, creating subtler sensations than other models.

This model of Aneros stimulator was not designed as much for prostate massage benefits, but for intense sexual stimulation.

Due to its advanced design, the Aneros Eupho is best reserved for experienced users who have developed their technique through experience and exercise with other models.

• Next-Generation Model
• Most delicate, agile and advanced model
• Thin stem requires strong PC sphincter muscles
• Dime perineum tab
• Polished to hold lubricant for better movement

Aneros Progasm – for Intermediate to Advanced users

The Aneros Progasm is the newest and largest member of the Aneros family.  It was created due to  popular demand for an even larger model than the Maximus. The result is a large model that can move easily because it is still agile due to design features.  It has a newly designed round perineum tab and also boasts a Kundalini "K-Tab." The "K-Tab" adds sensations up and down your back that are complementary to the sensations from the prostate.

Mobility of each Aneros model is achieved through PC muscle contraction and relaxation is the key to success for prostate massage and sexual stimulus.  Despite that it is the largest of the Aneros units, the Progasm moves inside the man's body to provide a robust prostate massage for incredible pleasure.

• For advanced and experienced users
• Largest Aneros model, but is very mobile
• Round perineum tab design
• Kundalini "K-Tab" provides additional sensations