What are your thoughts on Pentoxyfilline for Peyronie’s disease treatment?

Hello Doctor,

I’ve been dealing with this crazy Peyronie’s condition for about 18 months. In that time, I’ve visited 4 different urologists. The first was when I first experienced mild pain in the left tip of my penis. The doctor diagnosed it as prostatitis and send me on my way with some antibiotics. A second urologist several months later diagnosed me with superficial vein thrombosis. Finally, several months after that, I was diagnosed by a third urologist with peyronie’s which seemed to appear as long bands of inflammation from the base of the penis to the tip on both sides. I was told surgery was the only option, and was sent on my way.

Not satisfied with the suggested treatment plan of surgery, I decided to surf the web and do my own research. I found a site that promoted Neprinol as the only known cure. So I bought into it. I think I tried 2 full months (9 pills a day). The only result was a substantial hit on my wallet. So I went back to the web and found another site (PeyroniesForum.net) where members talk about various treatment options. The consensus on the site was that Neprinol was in fact a huge scam, and I stopped using them. Members also praised the use of Pentoxyfiline as being an outstanding product for softening scar tissue and alleviating curved penis. So I went back to a fourth urologist and asked for a prescription, but was denied. Instead, i was recommended to try the Andropenis traction device.

I’ve been on the device for 5 full weeks now, but I think I’ve decided to stop. Your website recommends against it, as well as another site. My urologist described it as working in a manner opposite of what a Nesbit procedure would be. For instance, rather than shorten the penis on the site opposite the scar tissue, traction would elongate the scar tissue to correct curvature that way instead. Made sense to me at the time. But now it sounds as if traction does not work because it’s not really stretching the scar tissue, rather only healthy tissue.

So if I stop with traction, I’ll be happy to not deal with that contraption any longer. It reminded me of having my penis in a mousetrap for 9 hours a day. Not to mention I always worried about whether people could see it jutting out through my trousers at work, and despised having to take it off every two hours to relax. That’s not always easy in the middle of a busy work day.

In any case, I came across your web site again. I’ve decided I’m going to give your “Medium” package a try, so I placed an order. I admit I’m very reluctant because you seem to be a heavy proponent of Neprinol, and I’ve heard people state emphatically that the product is a scam. I also ordered your Handbook. It’s expensive, but maybe there’s something in it that I can learn.

I do have a few questions if you wouldn’t mind responding. Today, I have two “knots’ in my penis. One that feels about the size of a dime on the right size near the base of my penis. Another is about the same size, also on the right size, but towards the tip. But my penis bends to the left when flaccid (sometimes 10-20 degrees, sometimes 45 degrees like after masturbation), and I can’t figure that out. That’s seems counter to everything I’ve heard before, that the bend is on the same side as the plaque.  So if you have any insight as to why my bend is to the left when my plaque is on the right, I’d be very interested. Regardless, that leads to my first question, how will I know where to apply the topical treatments? Would I apply to the right side where the “knots” or “bumps” are located, or should I be looking somewhere on the left side for plaque? Or should I just apply the treatment to the entire penis shaft? Maybe directions come with the kit, but any advice you can share would be greatly appreciated.

Second, can you share your thoughts on Pentoxyfilline and it’s effectiveness for Peyronie’s. Not sure if I’m spelling that correctly.

Finally, who can I find a coupon code? I noticed when I placed the order for one medium package and one book, that there was a place to enter a coupon code. I did some web surfing to find a code, but was unable. If you can share a code, or apply a n appropriate discount to my order, I’d greatly appreciate that.

Hope you’re doing well. Looking forward to your thoughts.


Greetings Mike,

Thank you for your informative letter and specific questions.  I will reply with comments and answers in the order of your email.

There is no direct known cure for Peyronie’s disease.  Neprinol is not a cure, but is is not a scam.  In my opinion, after working with many hundreds of men from around the world who are undergoing Alternative Medicine treatment of Peyronie’s disease, I know Neprinol is an excellent enzyme product.   It cannot be counted on as a solo therapy for Peyronie’s disease since none of the products found on the PDI website are by themselves able to change the PD scar or plaque material.  None of the therapies found on the PDI website are good solo therapies – they all must be used as part of a larger plan to support the natural healing process that is the only known form of cure for Peyronie’s disease.   When Neprinol is combined properly and taken aggressively the results can be dramatic.  I do not know how any of the experts on the various Peyronies forums actually used Neprinol when they took it, but many times when I communicate with men about their failure with  Neprinol I learn that they “tried it for a few weeks and it did not work,” or “I took two pills a day and it did not work,” or some similar manner of use that is doomed from the start.   In order to get results from Neprinol it must be used correctly.  If you bought your Neprinol from PDI we warned you not to use it that way; if you bought it from someone who does not know anything about PD you did not get that kind of help so you would know better.  Peyronie’s disease is a tough and tenacious problem to treat.  I am not surprised at your lack of results after using Neprinol as a solo therapy.

Here is a simple example that just occurred to me about Neprinol and PD:   Beans are a great food.  I like beans.  But by itself beans make a lousy chili – it is just beans.  For a good chili you have to add meat, garlic, onions, tomatoes, lots of different spices and a few other items.  It is only by combining the beans with all the other ingredients that you create chili.  None of the ingredients by itself is chili.  It is in using the correct technique (there are rules for bringing the ingredients together, you cannot just throw everything into a pot) when you bring all these things together to develop the magic that becomes a great bowl of chili.  Same with combining Neprinol with the other things your body needs to help it overcome and correct your curved penis and Peyronie’s disease.  

Pentoxifylline is popular with some urologists and not so much with others.  I think that those who actually prescribe pentoxifylline do so because they are tired of dealing with the other drugs that do not work and only use this one because they do not know what else to use.   Perhaps I am being overly skeptical and blunt in my assessment.   Some time back I wrote two articles that might be helpful on this subject, Pentoxifylline, Niacin and Peyronie’s Disease and Pentoxifylline and Peyronie’s Disease Treatment

Every month I hear more horror stories about the mechanical penis stretcher devices.    You did not indicate what problems you were having that you wanted not to deal with it any longer, but it usually has to do with pain as well as skin abrasions and blisters, and the fact that it does not work for the large majority of men.

The two plaque or internal scars you have located do not explain your deviation to the left.  My experience is that Peyronie’s plaque are usually multiple.  I suspect that the two you have found on the right are not the only ones that you have.  I suspect you also have one or more plaque on the left that are far more aggressive and instrumental in distorting your penis that those you have found on the right.   Let me know if you need help locating the other scars and I will assist you.   If you can not locate those scars on the left that are causing your distortion pattern I suggest that you apply the therapy at the deepest or lowest point of your concavity on the left. You could apply the DMSO, Super CP Serum and Unique-E vitamin E oil to the entire shaft if you wanted to, but it is unnecessary and wasteful; be as specific as possible.   I trust that the detailed DMSO instructions you received with your order cleared up this point for you. 

When you received your order you were given information about the use of a discount code for subsequent orders.

Let me know if  I can help you in any way.  TRH 


Spontaneous Remission of Peyronie’s Disease

Spontaneous remission of Peyronie’s disease 

Spontaneous remission of Peyronie’s disease occurs when PD simply goes away on its own.  No outside help or treatment is needed.  This happens more commonly than men are aware.  Peyronie’s disease is filled with many unknowns and controversy.  Self-healing of PD is just one of them. How often, when, and why a spontaneous remission of Peyronie’s disease happens are just a few.  Some say PD never goes away. But, others say it goes away half of the time.
The term “goes away on its own” is another way of saying “self-healed” or a spontaneous remission of Peyronie’s disease. This is not an example of playing with words.  There is no difference in what these terms mean. When the body rids itself of PD it is a spontaneous remission of Peyronie’s disease and a natural cure.  Hence, there is a cure for Peyronie’s disease.  The body is able to cure Peyronie’s disease.  It happens either rarely, or in up to 20-50% of the cases, depending upon whom you choose to believe – but it does happen.

Cure for Peyronie’s disease is natural healing 

Self-healing is an important choice to consider for treatment of Peyronie’s disease.  It means that a man can attempt to encourage or trigger his body do a better job of self-healing with Alternative Medicine.  By using different internal and external therapies recommended by PDI it might be possible to encourage or promote spontaneous remission of Peyronie’s disease.
What does a medical doctor mean when he says there is no cure for Peyronie’s disease?   He really means there is no drug that he can prescribe that is a Peyronie’s cure. We have established that the body can and does heal the Peyronie’s plaque in an undetermined number of cases. With the Peyronie’s Disease Institute therapy program we are attempt to increase the odds for a spontaneous remission of Peyronie’s disease.

Is cancer more difficult to treat than Peyronie’s disease?

A spontaneous healing, also called spontaneous remission or spontaneous regression, is the unexpected cure or improvement of a previously stable or worsening disease.  These terms explain the unexpected improvement of a cancer.  Everson and Cole explained spontaneous regression and remission from cancer in their 1966 book, Spontaneous Regression of Cancer, this way: “The partial or complete disappearance of a malignant tumour in the absence of all treatment, or in the presence of therapy which is considered inadequate to exert significant influence on neoplastic disease.”

Medical sources report that spontaneous regression of cancer is rare.  They estimate that spontaneous healing occurs at the rate of 1 in 100,000 cancers. Everson and Cole explain that at least for small tumors, the frequency of spontaneous regression had been was drastically under-reported. In their carefully designed mammography study they found that 22% of all breast cancer cases underwent spontaneous regression. They explain spontaneous remission or regression from cancer: “In many of the collected cases … it must be acknowledged that the factors or mechanisms responsible for spontaneous regression are obscure or unknown in the light of present knowledge. However, in some of the cases, available knowledge permits one to infer that hormonal influences probably were important. … In other cases, the protocols strongly suggest that an immune mechanism was responsible.”

Results for assisted spontaneous remission of Peyronie’s disease

If the body can cure cancer on occasion, why not Peyronie’s disease if you are doing many things at once to encourage a spontaneous remission?  Even without help, in 6-50% of cases of Peyronie’s disease the problem goes away on its own.  Think of how much more might be possible with help.

All of this should give you some encouragement about Peyronie’s disease self-treatment.  The Peyronie’s Disease Institute therapy program follows  a logical and reasonable course of action to promote self-healing. This is why since 2002 PDI averages 8-10 reports of moderate to marked improvement when using the PDI treatment program correctly, for every one report of failure.  That is an excellent ratio of success, or assisted remission of Peyronie’s disease.

Medical Peyronie’s Cure is Lacking

Peyronie’s disease cure right under your nose

Everyone wants a medical Peyronie’s cure that is a fast, easy, economical – and, oh yes – guaranteed.  In short, the ideal cure for Peyronie's disease from the traditional medical viewpoint would be simply to pop a pill or two.  In this way everyone with a bent nail could go about with his life as before, with minimal inconvenience or effort.

Why would I say that this is the viewpoint of “everyone”?   Well, simply because we live in a medical society.  When people think of a “cure’ they think of medicine as it is currently being practiced.   All efforts on the medical industry drawing board are directed toward looking for a drug – oral or injectible – to be the great cure for Peyronie’s disease that has evaded us for over 425 years.   Currently, Peyronie’s disease surgery is the only treatment that organized medicine makes available to someone with this problem and it is beset by limitations and drawbacks.

Other than the Peyronie’s Disease Institute no other effort has been made to seriously investigate a treatment for Peyronie’s disease outside of the traditional medical model.

This limited viewpoint of looking only for a medication to treat Peyronie’s disease is typical of the medical and drug industries.   The business people who decide how to approach a particular health problem tend to look at these issues from a profit standpoint; they also only look in directions and for treatment approaches that are not only profitable, but which they can control so that their profit is protected.

Since the perfect Peyronie’s drug has eluded the medical establishment, they are quick to say there is no known cure for Peyronie’s disease.   What this statement really means is that there is no known cure for Peyronie’s disease using a drug or medical procedure they can profit from, control, and manipulate.

There is a Peyronie’s cure

What kind of medical quackery and heresy – nonsense – is it to say that there is a cure for Peyronie’s disease?  Actually none.  The body itself, in a fairly high percent of cases, will heal and correct – cure – the Peyronie’s plaque so that the problem does not advance.  Peyronie’s disease eventually leaves without a trace of deformity, pain, scar formation or limited sexual ability for about half of the men who get this problem.  It is said that about in half of the men who develop Peyronie’s disease, within the first 12-24 months the entire problem will just go away on its own.  Does that sound like a Peyronie’s cure to you?  It does to me.

How does the body go about doing this miraculous thing, to rid itself of the terrible curved penis that is the hallmark of Peyronie’s disease, and heal over the mass of fibrous material that is known as the Peyronie’s plaque?  I do not know; no one knows.  But then again, I do not know how my body does the thousands of miraculous and complex things it does every second of every day of my life.  I do not know, as a small example, how my body can take the breakfast I just ate and convert into living tissue.  We are all just wonderful that way, and part of this is demonstrated when a man heals his own Peyronie’s disease.

The Peyronie’s Disease Institute is involved with the use of a wide variety of nutritional and supplemental products that are intended to increase and improve the ability of the body to heal the Peyronie’s scar.  It is really not so complicated or more mysterious than that.

For those who say it is quackery or nonsense to think that a person can improve his ability to heal and function better in life, I ask, “Why it is that a person eats?”

What is the purpose of eating?  To satisfy the taste buds?  No, that is just a side benefit.  We eat, we put nutrients into our body so it can function; the food we take in is fuel to enable life and repair to take place.   By following the ideas of the Peyronie’s Disease Institute about PD treatment, all we are doing is trying to increase the odds and opportunity for the body to heal and repair in a way that is better than what is happening now.  Call this a Peyronie’s cure if you want, but it is no more miraculous than anything else that your body does during the course of an average day.