Best Peyronie’s disease treatment, Neprinol 300 or Neprinol AFD?

Neprinol reduces inflammation and tissue damage

Neprinol is a completely vegetarian blend of several different enzymes that have tested to have over six time’s stronger activity to break down fibrin than the leading animal based enzyme blend product.  The enzymes in Neprinol have been shown to be clinically effective in supporting C-reactive protein (CRP) levels when taken as directed.  In this way Neprinol promotes normal levels of anti-inflammatory markers in the blood stream that are part of the physiologic response of the body while  dealing with acute (sprain, strain, overwork) and chronic (arthritis, most soft tissue disease, stroke, blood vessel disease) injury.  As a result Neprinol enzymes will assist the body in its effort to eliminate from the blood stream damaged red and white blood cells, fibrin, any protein material that is part of the inflammation process, as well as other cellular debris and foreign protein that can accumulate in the blood.

Neprinol AFD important in treatment of Peyronie’s disease because it affects fibrin

Fibrin deposition in Peyronie’s disease plaque

Immediately after injury occurs in the body, a protein called fibrin is deposited at the site of injury to act as a meshwork to trap and collect important blood cells and helpful components that create a clot that stops bleeding and promotes healing and repair of the recent injury.  This is normal.  After a period of time this mass of fibrin with it cellular collection changes so that the fibrin is removed and another protein called collagen fills in the spaces and changes the area of repair so that it resembles a fresh scar.  This is normal.  However, in Peyronie’s disease two abnormal things occur, for reasons that are not understood:  the fibrin does not leave the clot, and an excessive amount of collagen forms in the young scar so that it takes on a different name, a Peyronie’s plaque.  The way this fibrin and collagen collect and remain at the site of injury is consistent with repetitive injury to the small blood vessels of the penis.

The benefit of Neprinol AFD to Peyronies treatment is that it can break down and assist the removal of the fibrin that remains in the Peyronie’s plaque or scar.

Neprinol 300 most popular systemic enzyme sold by PDI

The ability to break down fibrin with enzymes, and to do it as economically as possible because it is a larger size bottle, is the reason some people call it Neprinol 300.  The high potency of two key enzyme ingredients, nattokinase and serrapeptase, address the concern about aggressively placing a systemic enzyme product as the foundation of treatment. Start by taking only four Neprinol 300 capsules daily, then slowly increase dosage while monitoring the size, shape, density and surface features of each Peyronie’s scar.  This is a great way to use this Alternative Medicine therapy for treatment of Peyronie’s disease. Neprinol 300 is recommended for both clinical use and therapeutic applications.

No difference between Neprinol 300 and Neprinol AFD

Whether you choose to call it Neprinol 300 or Neprinol AFD, these two terms are simply different names for the same potent enzyme therapy supplement that most people simply call Neprinol.

Neprinol continues to be by far the commonly used Peyronie’s disease therapy product.  Many times I have seen men who are following a particular plan that does not include Neprinol, and they experience slow or totally stalled results.  After adding Neprinol to that same plan it is common to learn that their recovery greatly improved from that point forward.

The name Neprinol 300 refers to the fact that Neprinol is bottled in either a 300 or 90 count bottle, for your benefit.  With the larger Neprinol 300 size bottle it is possible to take advantage of the reduced price of a greater supply and to purchase it fewer times; this is especially helpful for those who use Neprinol for chronic health problems that require prolonged treatment.  With the smaller Neprinol 90 count bottle it is possible to keep a smaller amount on hand for relief from occasional and mild overwork injuries or to simply get acquainted with the Neprinol product by taking a small amount of it.  By far, Neprinol 300 is a much more popular product.

The name Neprinol AFD refers to the primary purpose of Neprinol, as an Advanced Fibrin Defense therapy product.  Neprinol AFD is a name that tells the story that reduction and elimination of fibrin from the blood stream and tissue is what this product is all about.

Neprinol is safe

In over 10 years of use through the Peyronie’s Disease Institute there has been no report of any serious complication or adverse side effect associated with taking any systemic enzyme product like Neprinol, when it is taken in the way that we suggest.  Worldwide experience during this time has revealed, as well as clinical studies have demonstrated, that taking extremely large doses of this product does not result in a toxicity reaction.  Anyone taking a prescription for blood-thinning medication should consult with his treating physician prior to taking Neprinol.

Neprinol for Peyronie’s treatment

As good as Neprinol is when used to reduce Peyronie’s plaque material, it is almost always necessary to use several other in addition to the Neprinol to support and sustain the desired tissue changes.  Neprinol is best taken as part of an already good therapy plan, often used as a substitute for low dose nattokinase and serrapeptase supplements, although some men use all three products with very good results.

Neprinol AFD contains primarily serrapeptase, nattokinase, bromelain, and co-enzyme Q, plus a few other lesser ingredients. Other products also contain serrapeptase and nattokinase, individually, but few put these two in combination and none in the concentration of Neprinol AFD.  It is a more potent form of nattokinase and serrapeptase than if you would buy each in individual bottles, and the Neprinol 300 bottle itself is three times larger than most others that contain 100, to say nothing of smaller bottles with 60 or even 30 capsules.

However, in regard the idea of successful PD treatment is to not focus on any one particular therapy, even if it is a great one like Neprinol because the goal is to attempt to create a synergistic effect with several therapies taken at once for maximum therapeutic effect.  For this reason the Peyronie’s Disease Institute has always maintained that even if someone believes Neprinol (or any other) is a key PD treatment it should not be taken alone but combined for greatest therapeutic benefit.

No one knows how any one will respond to any or all of the 13 Alternative Medicine therapies found on the PDI website.  Some men report some positive results with just one therapy, but more men report better results when they take multiple therapies.  That is what the whole therapy concept of synergy is all about:  the more you do, the larger your plan, the greater the likelihood of promoting a favorable metabolic change to support and encourage scar reduction.  The PDI idea is not to “treat the scar” as a medical doctor would do, but to “treat the man who has the scar” so that his body can heal what is wrong with it.  This is a major concept shift for most medically indoctrinated people.  For this reason, as good a single therapy as Neprinol is, it is not recommended that anyone who is interested in earning good results in treatment of his PD scar should use just Neprinol – or just any one product – but several to create synergy.

Peyronies disease is a tough and terrible thing to happen to a man.  It takes dedication and persistence to overcome it.  Call it Neprinol 300 or Neprinol AFD, but definitely use it in a well diversified plan to break down the fibrin network of your Peyronie’s plaque material.  Success over this problem is never an easy victory, but always worthwhile.


Detoxification during Peyronie’s Disease Treatment with Neprinol

Consequence of systemic enzymes like Neprinol for Peyronie’s treatment

When using any of the systemic enzyme products (Neprinol, Nattokinase 1500 or Fibrozym) in a Peyronie’s disease Alternative Medicine program, it is not uncommon to go through a detoxification reaction.   Avoiding a detoxification reaction, and what to do if you have one, is the reason anyone who orders these particular products receives specific suggestions for their use.

Any of these systemic enzymes will destroy foreign fibrin in the body, regardless of the location of the fibrin material.  Over time as Peyronie’s plaque and fibrin is destroyed the greater the problem for the body is to eliminate the fibrin protein break-down products and tissue debris.  Like when you clean the attic – you must  find a way to get rid of all the accumulated junk.

When starting to use the systemic enzymes in a Peyronie’s disease treatment plan, this can amount to a flood of break-down debris that possibly can overwhelm the ability of the liver and large intestine for removal.  The end result is often nausea and diarrhea that are caused by this “housecleaning” that performed by the systemic enzymes.

Besides being no fun, the nausea and diarrhea problems that detoxification causes will also make absorption of nutrients more difficult and inefficient.   It is difficult for the body to absorb nutrients through the bowel wall while diarrhea is taking place.  For this reason I suggest that you stay at an enzyme dose high enough to just border on digestive distress (light occasional diarrhea and nausea, but definitely controllable), but less than having bad out-of-control problems.  This way you are attempting to still push for the benefits of detoxification without losing nutrients because your system is in a state of irritation from toxic overload.

Peyronie's treatment personal and specific for the individual

There is no one who can tell you the exact dosage to go about detoxification without developing a lot of diarrhea; you have to figure out how to do it; no one can do it for you. I suggest you not stay on a constant or level dose of enzymes.

Let’s say you wish to try a 6/day dose of your enzymes (either Neprinol, Serrapeptase or Fibrozym).  I suggest you start at 3/day and over a 7 day period slowly work your way up the level you wish.  If you notice a slight case of diarrhea starting, drop down to one less pill per day for a few days but do not totally stop taking the enzyme because you then interfere with your body’s tendency to adapt to and tolerate that product.  After a few day go back up to the dose that had caused a little diarrhea and you will likely have no problem.

As an option for those who want to take – as an example – 6/day of a systemic enzyme consider this effective variation.   Play with that 6/day dose by taking 5/day and 7/day on alternate days; or even 4/day and 8/day on alternate days.  This way, on the high days you are pushing yourself for detox but this is followed by a day of relative “rest” with the lower dose of enzymes so that you your gut does not stay irritated for a long time. This method also has the advantage you are not stopping your program; you are staying with it but modifying it for maximum benefit to you.

If you are taking these enzyme products you might consider trying this pattern of taking them for a few weeks.  I found I was experiencing toxic overload when I was taking about 12/day of Neprinol in addition to other systemic enzymes.  I did this higher/lower pattern and it really seemed to help.  Eventually I got to the point I could take up to 18/day of Neprinol with no problem at all.  This higher level of systemic enzyme therapy can be a little complicated, but it was definitely worthwhile for me.

Peyronie’s Disease Plaque Fibrin Patterns

Peyronie’s plaque is the heart of the problem

Peyronie’s disease is an abnormal collection of fibrous pathological tissue in the deep tissue layers within the substance of the tunica albuginea and the Peyronies plaque; it is also characterized by excessive deposition of collagen within that same plaque material. Even thought the cause of Peyronie’s disease remains unknown, direct injury or repeated small trauma is most often thought to be the two most likely inciting events eventually resulting in Peyronie’s disease.

Materials and Methods

To understand the onset and cause of the Peyronie’s disease plaque or scar tissue that is always present in every case of PD, it is necessary to follow a simple approach that examines for the presence of collagen, elastic fiber, and fibrin content within the PD plaque material and evaluate its distribution.

Peyronies plaque or scar tissue specimens were taken from 33 Peyronie’s disease patient volunteers, and control penile tissue samples and nodular tissue samples were taken from eight patients with Dupuytren’s contracture (a related and similar problem of the hand). These samples were analyzed to determine collagen staining characteristics, and patterns of elastic tissue distribution. In addition, plaque tissue from another 19 Peyronie’s disease patients, control tissue and nodular tissue from Dupuytren’s disease were also analyzed for fibrin in these same samples.


Abnormally stained collagen was found in 32 of 33 plaque specimens (97%), disrupted elastic fibers in 31 of 33 plaque specimens (94%), and abnormal fibrin deposits were also found in plaque tissue from 18 of 19 patients (95%). None of these abnormalities were located in normal or scared tunica from control patients.


These findings of fibrin deposits in Peyronie’s plaque tissue is consistent with the concept that repetitive injury and disruption of the small blood vessels and capillaries of the area results in fibrin deposition in the tissue space and has served to provide insights into the pathophysiology of Peyronie’s disease.