Why am I urinating more frequently since I started to take Nattokinase and Fibrozym?

For about a month and a half I have been taking 2 tabs of nattokinase 3xdaily and 3 tabs of fibrozym 3x daily. In this time I have to urinate more frequently including getting up 2x at night from sleeping.(not experienced before) Coincidence or do these pills cause more frequent urination? No extra liquid has been consumed. Thank you


This observation is made from time to time with men who use any of the systemic enzymes (Nattokinase, Fibrozym, Neprinol) when they have a large quantity of internal fibrosis.

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The explanation for the increased urination is that your body is pulling out additional fluid from your tissue to dilute the toxins that are being produced as the Nattokinase and Fibrozym breaks down the fibrous tissue in your system, especially the Peyronies scar. Some men have more fibrous tissue than others, hence they experience more frequent urination. This can be seen as a good thing since it shows you that the systemic enzymes you are taking are working for you.

Please keep me informed of your progress. TRH


Should I take Neprinol instead of Fibrozym, or with it, for my Peyronie's disease?

I ordered the medium package and in it was a sample for Neprinol. I noticed it has a lot of the same things Fibrozym has. Is this something that would be used instead of other products, or on top of? If in place of do you like it better and which products would it replace.

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Thanks a million.


Neprinol has many of the same ingredients as the Fibrozym and Nattokinase 1500 therapy products PDI sells, but Neprinol also has additional ingredients and all ingredients are in higher concentration.

Some men use Neprinol as a substitute for Fibrozym and Nattokinase 1500, meaning once they start taking Neprinol they do not use the other two enzymes products. And other men use all three enzyme therapy products, but they use more of the Neprinol and only lesser amounts of the Fibrozym or Nattokinase. Using these different combinations, and all the possible different dosages of each, provides a wide variety of treatment options to get the best possible response from your PD treatment plan.

The changes and modifications in how you take these different enzymes should be done while experimenting and watching for changes in the size, shape, density and as surface features of your Peyronie's scar. Taking Neprinol as the only enzyme or taking with the other two is not just a whim or something you THINK would be good to do, but it is something that you actively experiment with to see how the therapy change affects your scar structure. Any change in your therapy plan like this must be evaluated to determine if it causes a desirable and beneficial change in the scar you are monitoring. So you can ask me what I think you should do, but I will only answer, “Try doing several different combinations with the enzymes and see what happens to the scars. That is the best way to know exactly what needs to be done to get rid of your Peyronie's disease.” You will see that your scar will show you exactly what needs to be done to get the best response.


Which enzyme preparation is most effective for Peyronie's disease treatment?

What enzyme preparation do you feel is the most effective, and has the highest quality control in its manufacture, Neprinol, Fibrozym or Nattokinase?

What is the reason you don't recommend Serracor or Serra RX?


Effectiveness of Neprinol, Fibrozym or Nattokinase is never evaluated in a vacuum. Since I have never used them alone or recommended any of the PDI therapies to be used as a solo treatment, I cannot speculate in that way for you. Each product undergoes rigorous laboratory testing to prove each is effective in its ability to degrade and catabolyze fibrous protein molecules, so we know each is effective in that regard. The question you are asking has never been investigated because it is contradictory to the way these products are used and the philosophy of synergistic Peyronies treatment I promote on the PDI website.

The quality control issue is equal for the manufacturers of Neprinol, Fibrozym and Nattokinase since each fulfills the government standards for laboratory testing and manufacturing practices.

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I do not recommend Serracor or Serra RX because I was around before these products existed and I know some of the nasty history behind them, and the lawsuits that did not go in favor of the manufacturer of Serracor and Serra RX. Given that, I think it is more prudent to stay with an older, larger and more stable company. TRH


Should I take Neprinol with other enzymes or by itself?

Hi Dr. Herazy, 

Should I take Neprinol with Fibrozym and Nattokinase, or just take it by itself?   Jerry 

Greetings Jerry,

Just so we are clear on what you are asking me, I know you are following a larger PDI therapy plan so I am confident you are also using other therapies besides the Neprinol, Fibrozym and Nattokinase you mentioned.   The way you asked your question I could get the idea you wanted to just use Neprinol by itself.  If that what you are thinking of doing, then I strongly advise against that.  I have never spoken to anyone who has earned good results by using Neprinol as a solo treatment for Peyronies.  You always want to diversify and broaden your treatment base with a variety of internal and external therapies, right?  

Men use Neprinol both ways – as a total substitute for the other enzyme products, or in addition to them (usually with the Neprinol being the primary enzyme source and the others being used as a minor role). The choice is yours.

I would consider using just the Neprinol as the only systemic enzyme, and see how it goes. If that is not enough to get the scars to change favorably, then bring back the Fibrozym, or Nattokinase, or Quercetin/Bromelain, or all of them into your existing therapy plan.

You must keep experimenting to learn what Peyronies treatment makes your scar size, shape, density and surface features respond favorably and then go with that.

Detoxification during Peyronie’s Disease Treatment with Neprinol

Consequence of systemic enzymes like Neprinol for Peyronie’s treatment

When using any of the systemic enzyme products (Neprinol, Nattokinase 1500 or Fibrozym) in a Peyronie’s disease Alternative Medicine program, it is not uncommon to go through a detoxification reaction.   Avoiding a detoxification reaction, and what to do if you have one, is the reason anyone who orders these particular products receives specific suggestions for their use.

Any of these systemic enzymes will destroy foreign fibrin in the body, regardless of the location of the fibrin material.  Over time as Peyronie’s plaque and fibrin is destroyed the greater the problem for the body is to eliminate the fibrin protein break-down products and tissue debris.  Like when you clean the attic – you must  find a way to get rid of all the accumulated junk.

When starting to use the systemic enzymes in a Peyronie’s disease treatment plan, this can amount to a flood of break-down debris that possibly can overwhelm the ability of the liver and large intestine for removal.  The end result is often nausea and diarrhea that are caused by this “housecleaning” that performed by the systemic enzymes.

Besides being no fun, the nausea and diarrhea problems that detoxification causes will also make absorption of nutrients more difficult and inefficient.   It is difficult for the body to absorb nutrients through the bowel wall while diarrhea is taking place.  For this reason I suggest that you stay at an enzyme dose high enough to just border on digestive distress (light occasional diarrhea and nausea, but definitely controllable), but less than having bad out-of-control problems.  This way you are attempting to still push for the benefits of detoxification without losing nutrients because your system is in a state of irritation from toxic overload.

Peyronie's treatment personal and specific for the individual

There is no one who can tell you the exact dosage to go about detoxification without developing a lot of diarrhea; you have to figure out how to do it; no one can do it for you. I suggest you not stay on a constant or level dose of enzymes.

Let’s say you wish to try a 6/day dose of your enzymes (either Neprinol, Serrapeptase or Fibrozym).  I suggest you start at 3/day and over a 7 day period slowly work your way up the level you wish.  If you notice a slight case of diarrhea starting, drop down to one less pill per day for a few days but do not totally stop taking the enzyme because you then interfere with your body’s tendency to adapt to and tolerate that product.  After a few day go back up to the dose that had caused a little diarrhea and you will likely have no problem.

As an option for those who want to take – as an example – 6/day of a systemic enzyme consider this effective variation.   Play with that 6/day dose by taking 5/day and 7/day on alternate days; or even 4/day and 8/day on alternate days.  This way, on the high days you are pushing yourself for detox but this is followed by a day of relative “rest” with the lower dose of enzymes so that you your gut does not stay irritated for a long time. This method also has the advantage you are not stopping your program; you are staying with it but modifying it for maximum benefit to you.

If you are taking these enzyme products you might consider trying this pattern of taking them for a few weeks.  I found I was experiencing toxic overload when I was taking about 12/day of Neprinol in addition to other systemic enzymes.  I did this higher/lower pattern and it really seemed to help.  Eventually I got to the point I could take up to 18/day of Neprinol with no problem at all.  This higher level of systemic enzyme therapy can be a little complicated, but it was definitely worthwhile for me.