My doctor wants to put cortisone injections into my Peyronies scar, what do you think of that?
Will steroid injections reduce the inflammation and pain of my Peyronies?
What is the Dr's opinion on using the prescription Edex injected with a syringe?
Bryant from Ohio
You ask for my opinion about Edex injections. I will not comment on the drug, because that is the decision of your treating doctor. But I will make a few observations about injections in general and how they could further injure the tunica albuginea.
Anytime you inject ANYTHING – even sterile water – into the penis and directly or indirectly contact the delicate tunica albuginea, you are taking a serious risk of making your Peyronie's disease worse. This could either occur just from the simple act of piercing the tissue of the tunica albuginea, or the placement of a concentrated chemical that is foreign to that tissue, or both.
I have communicated with many, many men whose Peyronie's disease started or was made worse from penile injections of a variety of substances.
If your problem is PD, why are you taking an ED medication? Some MDs prescribe Viagra, Edex, etc to their PD patients in the belief that this increases the local circulation which in turn is beneficial to PD.
What if you could take a drug that would enable you to lift a ton of weight above your head and keep it there for an hour? Nice trick, very impressive, but your body is not built to take that kind of pressure. It would cause great damage to internal organs, your spine, your blood vessels, all major joints, etc. Simply put, “It just ain’t natural.” Same with Viagra, Levitra or Cialis. The increased pressure created by these medications can be very damaging to the delicate tunica albuginea, and can result in or worsen a case of PD. What would happen to your car tires if you happened to over-inflate them with 100 pounds of air pressure, even though they were built to take just 40 pounds of pressure. You would be running the risk of damage to the internal structure of tire, wouldn’t you? Of course.
The same thing can happen if the penis is over-inflated and then given a “rough ride.” This is where the problems start, and this is what I wanted to bring to your attention. It is very likely that the MDs who prescribe these medications to men with PD will not agree with this thinking. MDs tend to favor a chemical “fix” even if it is temporary, so you would tend to expect a prejudice from an MD to use drugs to solve most problems.
A penis that is predisposed to PD in the first place cannot tolerate the kind of stress that these erections drugs create. If you think independently and logically about what happens when these drugs are used, you should have no trouble understanding how this could work against you. That is just the way I see it and I feel compelled to share this rationale with you. Use of Viagra and other related meds like it could easily be worsening the very problem you are attempting to heal. Something to think about. TRH
I have Peyronie's disease causing a bend to the left and downwards and it's closer to the tip then the base. I have seen a urologist who has injected it twice now. I haven't seen any improvement. both my doctor and myself have trouble finding any plaque. I'm 50 and in good shape….this just showed up a couple of months ago…there was no trauma…should I continue with the injections? .
It is not my intention or desire to interfere between you and your urologist concerning your treatment or any other aspect of your relationship. Nor will I answer your question directly if you should or should not continue with the penile injections you are receiving – I have no direct opinion or advice for your question. That is a subject for discussion between you are your treating doctor. My only interest and purpose in making this reply is to offer ideas, and pose questions to you, to broaden your discussion with the urologist about the progression of your care.
My opinion and ideas for you to consider are these:
1. Any time you make a simple injection into the penis with anything, even sterile water, you are physically traumatizing the thin tunica albuginea membrane where the Peyronie's plaque is located. Many times when these injections are given at multiple sites of the tunica albuginea at one office visit, causing multiple trauma. Yes, these are small needle holes, but they are holes none the less. When given at multiple sites within a small area, and done on multiple occasions, that is still a lot of trauma (think of a shot gun blast which is just a lot of small holes). Your body has already demonstrated the tendency and ability to lay down excess collagen in the form of Peyronies plaque without any trauma or trauma so small that you do not remember it, so what will be its reaction when actually traumatized? It is my opinion that any injection is a direct injury that could possibly cause more plaque or scar tissue to develop or worsen plaque already present.
Avoidance of the trauma of needle injection is the reason that since 2002 I have counseled perhaps 20 or so MDs (of whom 2 were urologists) who had PD and wanted to avoid surgery, injections and drugs.
2. The needle injection points are not the only potential trauma to the tunica. Since you did not mention what drug was being injected by your doctor, I cannot comment specifically on that issue, but it is my opinion any drug has a potential to cause chemical trauma in the form of an allergic reaction, side effect or perhaps just a chemical irritation to the tunica in certain individuals. If this is the case with you, this could result in additional irritation internally and further trauma to tissue that has already created Peyronies plaque for no apparent reason you recall. It is my opinion that any drug reaction or unexpected side effect could possibly result in additional plaque or scar tissue or further aggravate plaque already present.
Unexpected drug reactions and unexplained side effects are a fact of life in medical practice. This is such a large problem that there is a medical term for it, "Adverse Drug Reactions" or ADR. In fact, a 1999 report in JAMA of a meta-analysis entitled "Incidence of Adverse Drug Reactions in Hospitalized Patients" by J. Lazarou concluded that
Conclusions.— The incidence of serious and fatal ADRs in US hospitals was found to be extremely high."
I am not at all suggesting that any penile injection could cause a fatal reaction, but I am suggesting that if in hospitals serious and fatal ADRs occur at the rate of 6.7%, the rate of less serious ADRs must be even higher. All of this means that drug reactions occur at a seriously high rate, you are taking drugs directly into the penis, and you are already in a position in which you should be extremely careful because your penis will probably overreact if it is further injured.
3. If you say that you and your doctor have trouble finding any plaque, then where are these injections being given? If the exact location cannot be confidently identified by your doctor, then how accurate is the placement of these injections you are receiving?
4. It is estimated that 50% of men who begin Peyronie's disease will self-limit or cure their own problem without any outside help or medical care. The Alternative Medicine treatment concepts of PDI is simply to do all that you can with natural methods to increase the natural healing ability of your own immune system to eliminate your Peyronie's plaque. How to go about doing this is the subject of the large PDI website. I suggest that you, and everyone else with Peyronie's disease, consider attempting conservative measures before undertaking more aggressive Peyronie's treatment that has potential for side effects and drug reactions.
Good luck in discussing this subject with your urologist. TRH
Calcium channel blockers, or calcium antagonists, are a class of medications as well as natural substances (D-glucaric acid) that disrupt calcium ion conduction along what are known as the calcium channels of the body.
While some doctors use calcium channel blockers to treat Peyronie’s disease, there are researchers who have evidence that these very same calcium channel blockers can actually cause Peyronie’s disease. This shows how strange and up-side-down is the world of Peyronie’s disease treatment.
The most widespread prescription use of calcium channel blockers is to reduce elevated blood pressure in patients with essential hypertension, particularly elderly patients. Calcium channel blockers are notably effective to reduce large blood vessel stiffness, a common cause of elevated systolic blood pressure in geriatric patients. They are also used to control and reduce rapid heart rate, prevent spasms of brain blood vessels and reduce chest pain due to angina pectoris.
Calcium channel blockers, or calcium antagonists, also treat a variety of conditions, such as Peyronie’s disease, high blood pressure, subarachnoid hemorrhage, migraines and Raynaud's disease.
All tissue of the body requires oxygen, and the heart muscles in particular need oxygen to pump blood. The faster and harder the heart pumps blood, the more oxygen it needs. Heart pain occurs when the amount of oxygen available to the heart muscle walls is inadequate for the work load of the heart. Calcium channel blockers dilate the large arteries that supply blood to the heart muscles, and thereby reduce the pressure within those arteries. This action reduces the stress on the heart muscles and reduces the need for oxygen at the same time, thus reducing angina pain. In similar mechanism, calcium channel blockers reduced elevated blood pressure, and slow the rate at which the heart beats in a condition known as tachycardia.
One type of calcium channel blocker known as a phenylalkylamine calcium channel blockers, is called Verapamil. It is used in the treatment of Peyronie’s disease because it is thought to be effective in disrupting the calcium ions found within the Peyronie’s plaque, thus slowing or reversing the development of the offending plaque material that is the cause of the notorious Peyronie’s curved penis.
Peyronie's disease is a complex health condition without a known cause that affects nearly 4-6 percent of the worldwide male population. It is best characterized by the development of internal fibrous plaque material below the surface of the penile shaft that results in curvature of the penis, as well as pain. Peyronie’s disease typically on average at age 54, yet men of all ages (from 16 to 80) can and do develop it for reasons that are not consist or clear.
Some medical doctors prescribe a topical gel of the calcium channel blocker, Verapamil to be applied once or twice daily over the area of the Peyronie’s plaque. Since it is thought that calcium channel blockers change the way that calcium is bound within the plaque, that it might slow or reverse the development of Peyronie’s disease. While this form of treatment has not proven especially effective, and has fallen out of general favor, other medical doctors attempt a more direct route of administration by injecting Verapamil directly into the plaque material of the penis. This can be a rather painful treatment, and is often given in series of 12 to 20 injections over time. Verapamil injections have not proven to be especially effective, either, yet remain on the list of medical therapies because it offers some avenue of treatment for both patient and doctor who do not have much medical treatment available for this troublesome and persistent problem.
In addition to the problem of inconclusive results and lack of support within the medical community for the use of Verapamil drug injections as a Peyronie’s disease treatment, there is also the vexing problem of trauma to the delicate tunica albuginea by repeated piercing of these multiple injections.
While there is still debate if calcium channel blockers actually cause Peyronie’s disease in healthy men, as well as if it can be used to treat Peyronie’s disease in those men who have it, the use of verapamil appears to be reducing if only because of discouraging clinical outcomes.
The Peyronie’s Disease Institute has maintained since 2002 that it makes sense to attempt to restore and support the natural healing ability of the body to correct Peyronie’s disease as occurs in about 50 percent of men who develop this condition. Read how you can use many Peyronie’s disease natural treatment options to help your body heal and repair without risk or danger of unnecessary drugs or surgery.