Is there a connection between using Cialis and Peyronies disease?

Is there a connection between using Cialis and Peyronies disease? The reason being is because I had no signs of the disease developing. I woke up one morning to find the scar/plaque on my penis when I went to the bathroom. Overall I took about 13 pills over 6-7 weeks, only taking one at a time. My doctor examined me and confirmed that I have it but did not offer anything solutions or why it happened. He did say he was surprised that it just came on as fast as it did which was like overnight for me.  I know my body and I was completely surprised.


Cialis is a member of group of drugs called PDE5 inhibitors, used to treat symptoms of erectile dysfunction (ED). Other members are Viagra and Levitra.

Yes, there definitely appears to be a connection between using Cialis and Peyronies disease.   Over the years I have encountered many men whose Peyronie's disease started after using just one dose of a PDE5 inhibitor.  There are many lawsuits pending in this regard.

Here are a few of the posts I have written about this subject over the years: Peyronie's disease plaque, Viagra, Cialis, Levitra and blood supply, and Peyronie's disease treatment and Viagra, Cialis and Levitra; there are others if you look further on the website.  TRH

Peyronie’s Treatment and Cialis


Peyronie’s and Cialis (Tadalafil) and PDE5 inhibitors

Peyronie’s and Cialis are both on the rise – no pun intended, and there is a reason for that.

Cialis it is not a Peyronie’s treatment; Cialis is used to treat erectile dysfunction (impotence).   Some MDs use Cialis in Peyronies treatment because they think it will help the patient achieve a stronger erection  since Peyronie’s disease and impotence or erectile dysfunction often occur together.    But    This practice is is coming under close scrutiny because Viagra, Cialis and Levitra (all the PDE5 inhibitors) can make Peyronies worse if they cause a very extreme erection that the body is not built to handle.  This can cause damage to delicate tissue and more Peyronie's plaque formation.

Peyronie’s and Cialis Usage

Every man should know each package of Cialis contains information warning that men with Peyronie’s disease should use Cialis with great caution because of possible side effects that include damage to the penile tissue that can actually cause Peyronie’s disease if you do not already have it.

MDs write orders for their patients with Peyronies and Cialis is a commonly prescribed drug.   The MD will explain that the Cialis will increase the blood flow to the penis and this makes it beneficial to Peyronie’s disease.  I think this is nonsense.

An erection is created when blood is TRAPPED inside the penis, causing the spongy tissue to fill up and expand with about 2-3 tablespoons more blood than is normally in the penis.  This additional 2-3 tablespoons of blood become TRAPPED inside the penis, just like when you blow up a balloon and tie a knot at the end of the balloon.  Sure there is more air inside the balloon, but it does not circulate freely – it is stagnant air. And the additional blood also does not circulate freely in the penis.  That is why the penis is darker when it is erect – the blood does not have much oxygen in it, making the tissue darker.  This just goes to show how little many MDs think about what they are doing when they write a prescription.

Cialis is a popular erectile dysfunction drug, but it does not make sense to use it for treatment of Peyronie’s disease. When a man goes to his doctor for his Peyronie’s and Cialis is prescribed, he should understand the reason for the prescription does not make sense.

Cialis and Peyronie’s Connection

While I hate to spoil the fun for those whose sex life is enhanced by Cialis, but over the years I have had a disturbing number of men inform me they now have Peyronies and Cialis use was the cause.  Any of the PDE5 inhibitor drugs (Viagra and Levitra are others) can increase pressure within the penis that  can be greater than normal.  Injury to the tissue can lead to Peyronie’s disease.

If it were possible to take a drug that would allow you to lift a truck above your head and keep it there for an hour, should you do it?  That would be an interesting, and very impressive to the ladies, but is that reason enough to subject your body to the potential risk that would be involved?   The fact is that the body is not built to be used that way.  Lifting a great amount of weight causes internal pressure on tissue and organs that were not meant to bear that kind of weight.  Great injury would occur to internal organs, your spine, knees, hips, shoulders, blood vessels, and so on.  The same relationship exists between Peyronies and Cialis, and the rest of these PDE5 inhibitors.

All of this is so unfortunate because there are far safer methods for Peyronie’s disease treatment.

The increased occurrence of Peyronies and Cialis use also increasing is not a coincidence.  There is a reason that more and more men are getting Peyronie’s disease at the same time that more and more men are using Cialis and the other PDE5 inhibitors.