What is the maximum "safe" daily dosage of Vitamin E for treatment of Peyronie's disease?

What is the maximum “safe” daily dosage of Vitamin E (for example, Unique E) in IU that is recommended for treatment of Peyronie's disease. I have read that daily doses in excess of 1500 IU of d-alpha tocopherol can be potentially toxic. I am planning on taking Vitamin E, with Nattokinase 200mg 2x/day, and PABA 1000mg 3x/day. Any comments on this regimen are appreciated.

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Greetings,

Please search this website for many articles I have written about safety of taking vitamin E within a Peyronie's disease treatment plan.  For example: Peyronie's disease treatment and vitamin E  and  Peyronie's disease vitamin E therapy.

To answer your question directly, I usually recommend that a man takes 800-1200IU of Unique E daily in a Peyronies plan.

Concerning the brief plan that you have outlined, above, I suggest that you consider adding some external therapies to this plan (DMSO with related copper peptides and vitamin E as topical applications, gentle manual penis stretching, ultrasound, etc.).  Your plan as you describe it is not fully developed.  I suggest that you look at the small, medium or large PDI plans to get an idea of what a well rounded plan looks like.

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Is pycnogenol good or bad for Peyronie's disease?

Good morning,

I have recently ordered the alternative large package and I would like to ask you the following.

I have the Peyronie disease and for other reasons I am taking a supplement of (Solgar) called pycnogenol. If I have well understood this product is related to collagen. Can you please advise me if this is good for the Peyronie's disease or bad and whether I should stop taking it or not?

Thanks/Regards,
Panos

Greetings Panos,

I am very familiar with pycnogenol, which is an extract primarily from the bark of a pine tree, pinus pinaster, although the same pycnogenol can removed from peanut skin, grape seed, and witch hazel bark.  The reason that it is not included in the PDI lineup of therapies is that it has not been subjected to any testing for Peyronie's disease that I can determine.  Not everything possible that could be remotely effective for Peyronie's treatment is included in our PDI treatment concept; only those things that have received a sufficient level of testing and produced some positive research findings but insufficient to be considered a complete cure.   Pycnogenol has not been tested at all in that manner and so will not be considered for inclusion until it is.   

When you consider how to go about treating your Peyronie's condition you have to determine that it is not the scar you are treating but your total body and your ability to heal and repair the PD scar.  The best route for Peyronie's disease treatment is different for each man.   This is why there are so many variations of the different plans that are being used.

Pycnogenol is often mentioned as being effective for treatment of many diverse problems: asthma, allergies, skin problems, elevated blood pressure,  reduced blood circulation,  muscle soreness, pain, arthritis, menopausal symptoms, painful menstruation, diabetes, retinopathy and erectile dysfunction, to name just a few.  It is also commonly used by those who are interested in its anti-aging benefits.  

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It is your decision to continue taking it or not.  TRH

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Cortisone injections and Peyronie's disease

My doctor wants to put cortisone injections into my Peyronies scar, what do you think of that?

Will steroid injections reduce the inflammation and pain of my Peyronies?

My opinion is that it is risky to use cortisone injections as a Peyronie's treatment.  While a temporary and variable reduction of pain does occur in some cases, but not all, it is not worth the limited benefit that makes future Peyronies surgery more complicated and dangerous should it become necessary.  There is good reason to think twice about using steroid injections for this purpose.  This website has presented an earlier article about a closely related topic, Peyronie's disease treatment via direct drug injection.
It would be good to talk to your doctor about other treatment options or to consider using Alternative Medicine as a way to increase your natural ability to eliminate the Peyronies scar.  The PDI website explains how this can be done without the use of drugs and surgery.
In the 1960’s steroid (cortisone) injections were used as a Peyronie’s treatment under the theory that they would reduce plaque or scar formation because of the inhibitory effect cortisone has on fibroblast cell formation. Since fibroblasts are cells that make fibrin, and fibrin makes collagen in the body, with fewer fibrin cells the ideas was that this would result in less collagen produced during scar formation.
This treatment for Peyronie’s was used rather extensively until the mid-1980s when it became obvious that it did not consistently or greatly reduce collagen at the Peyronie’s plaque. And of equal concern was the observation that these steroid injections were causing penis tissue weakness (atrophy) of blood vessels, nerves, and all connective tissue of the corpora cavernosa and tunica albuginea of the at the site of the injections near the Peyronie’s plaque. These steroid injections resulted in weak and fragile tissue that would easily tear when a surgeon would try to sew it together during surgery, or worse yet would tear after surgery or heal slowly or not at all.

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It took a long time to notice and correlate this problem because virtually all of the studies of using cortisone injections in Peyronie’s disease did not use a placebo control, and they performed with only a small number of patients who reported their improvement subjectively without objective measurement of progress in terms of pain, plaque formation and deformity reduction.
Seldom did the steroid injections actually have a beneficial effect on the eventual Peyronie’s disease outcome, but had an undesirable side effect that made Peyronie’s surgery complicated and less effective. The problem was that the broad tissue destruction caused by the cortisone made the tissue so weak and compromised that a surgeon could not later go into that same area to suture the tissue closed at the site of a surgical incision, or expect the sutures to hold on the weakened tissue. If penis surgery was done it often resulted in frequent bleeding and repeated opening of surgical wounds. Once it was seen that cortisone injections made it difficult to do good surgery later, the practice began to fall out of general use.
In addition, the practice of using cortisone injections for treatment of Peyronie’s disease did not take into account the harmful effect of placing a series of multiple needle punctures into the scar material and the tunica albuginea tissue of the penis. Later clinical observations have shown that these frequent and repeated needle punctures act as additional trauma to tissue that has already shown itself capable of producing excess scar formation to repeated small injury. This has also proven to be the case when a series of multiple injections of other drugs like verapamil and interferon are used as Peyronie’s treatment. The clinical results of these other drug injections have not provided positive or encouraging clinical results that were any better than those of cortisone injections.
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How should I change my Peyronies treatment plan to get better results?

Dr. Herazy,

I have been using the following and not seeing many changes. I’m wondering what I should increase.

Externally: Super CP Serum, Vitamin E then DMSO 3 x day

Internally: 2 Neprinol, 1 Quercetin/Bromelain and 1 Acetyl-L-Carnitine 3 times daily between meals
1 Ascorbplex 1000mg and 1 Unique E 400mg 2 times day with meals

I will also order the ultrasound unit to go with the treatment.

Thanks for your help.

Michael

 

Greetings Michael,

You need to tell me when you are taking these products and if/how they are being used during the day.  I can at least tell you that your  plan is rather limited and light compared to those who get good results with their Peyronie’s disease treatment plans.   I suggest that you set up an appointment to have a telephone discussion with me soon to get you on the right track.  TRH

Natural vitamin C for Peyronie’s disease treatment

What does your natural vitamin C have in it?  Why is it called natural? Thank   Dave G

 

Greetings Dave,

The vitamin C product from Douglas Laboratory is highly regarded for its quality and purity, and is the reason PDI has selected it as part of all Peyronie's disease treatment plans. It contains 1000 mg of ascorbic acid and the full bioflavinoid complex as is found in rose hips.  The base of the rose is a powerful source of vitamin C as it occurs in nature.  The vitamin C in this supplement is extracted from the hip of the rose plant (right below the base of the flower petals) and this is why it is called "natural".  TRH

Neprinol in a Peyronie’s disease treatment plan

I have had Peyronie's disease for about a year now. I have been doing lots of research and plan to purchase your medium plan. I feel that will be a god starting point. I have seen some other options with success stories, in particular, Serracor-NK mixed with Serra RX 80. My question is can I add these supplements to your medium plan in hope to defeat the disease better. Is that healthy, or would that be too much? I read that the Serracor-NK has nattokinase in it which is one of your supplements in the medium plan, so would this be pointless or do you think that would be ok?

Thanks

 

Greetings,

It seems most everyone makes changes and adds variations to the basic PDI-based treatment plan.  I cannot comment on the products you mention because I have no direct experience with them.  The problem with using these products is that I have been told that there is little information that has been made available about how to use these products.  

The medium plan is already a well diversified way to increase your ability to reduce your Peyronie's disease. I suggest that you simply start with the medium plan and see what it can do for you as it is presented.  If at a later time you think you might want to add some additional therapy you could always use the products you mentioned.

When you order your medium plan you will be impressed with the amount of information you will receive that describes in great detail how to use each component of the 10 items in that plan.  No one says that they do not understand how to go about using their therapy products after reading the information that is given with each order.

Lastly, in my opinion Neprinol is a better fibrinolytic enzyme product than those you mention, based on the formulation and the feedback I receive from people who have used both.  That is why we promote its use and not other enzyme products.  The ultimate decision is always yours.

Let me know if I can help you in any way.  TRH

Please Doctor Herazy you are the only person who I think can help my Peyropnie’s disease

Dr Herazy,

I am a young adult male from CA. I have been cursed with Peyronie's disease at a young age and it is destroying my youth. I am practically bed-ridden with depression and I can't even sleep right anymore. All I want is to fix my Peyronie's disease. My plaque doesn't even cause bending, it is in the base of the penis and is causing a severe narrowing of the tunica. My erection hangs low now and the deformation can be seen easily. You could call it "baseball bat" shaped. I lost my job due to my severe depression this has sunk me into an even deeper state of gloom. I can't afford to pay for anything on the site. Please Doctor Herazy you are the only person who I think can help me. Everything else is just suggesting thatcher's formula or surgery, but they think my penis is curved.

I eagerly await your reply.

-Thom

 

Greetings Thom,

I could write a 10,000 word response to your email, but I simply do not have the time or opportunity to reply to all the  levels of the different problems that you express in your email. 

The fact that you do not ask a question in your email suggests that you have not attempted to learn about how you might be able to help yourself out of this problem. You wish for me to fix your problem, and I cannot; only you can.  The fact that you suggest I am the only one who can help you tells me that you are not taking any responsibility for your recovery but would rather put that burden on me. This is not the way that Peyronie's disease treatment works, and for that matter it is not the way that anything in life works. You need to re-evaluate this aspect of your personality and mindset to see how this has affected your response not only to Peyronie's disease but to other aspects of your life.  

You are making your situation worse by wallowing in self pity and you amplifying how your condition is affecting you.  You are the one allowing yourself to be bed-ridden with depression. You are telling yourself that your life is being destroyed and you are believing that voice as though it was the truth. You are making your problem worse than it is, you need to take control of yourself, and you need to correct these deeper and larger issues that bother you.    

You say you are bothered by your observation that the baseball bat deformation can be easily seen. You are investing far too much worry and energy in the idea that someone else will look at your deformity and think less of you. This bothers you as much as it does because you already do not think much of yourself and have been bothered by low self-esteem for most of your life.  I suggest that your poor self image is what is really at the base of why you feel that your youth is being destroyed.       

I also suggest to you that you have always had many problems in life that have overwhelmed you, and Peyronie's disease is just the latest to flatten you out emotionally. 

Please allow me to help you by telling your to seek professional help for your other problems.  In the meant time, you should investigate a bit about Peyronies treatment and attitude.   TRH

How is DMSO applied in a Peyronie's disease treatment plan?

Hi doctor,

I just have a quick question regarding applying DMSO to my curved penis. Will it still be effective to the fibrous plague even my Peyronies disease condition started a long time ago. I had developed a curved penis since i was young and i am now 28. Looking to purchase your BETTER PLAN. How should one apply it? on erect state or not? Thank you and hope for your response.:)

Ollie

Greetings Ollie,

Are you sure you have Peyronie’s disease? Have you been formally diagnosed with PD? Perhaps you were born with a normally curved penis.

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Assuming you do have Peyronie’s disease, the medium plan is by far the most popular. DMSO is an important part of the overall therapy. All instructions you need for using every part of the medium plan are included when you receive your order; you will not have any questions about how to use the DMSO or any other part of the plan.

To answer your question, the DMSO is applied in the non-erect, or flaccid, state.

Let me know if I can help you in any way. TRH

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How can you help my Peyronie's disease situation?

Hello,

I have, what I believe is the early stages of Peyroine's disease.

I have a very distinct and sudden narrowing of the base of the penis, on the left, but little angular distortion, and no palpable scar tissue. I do have have the pain associated with this condition.

I am fortunate that I found your site, and identified the condition before it becomes more established.

I would like to prevent this from escalating and of course return to normal ASAP.

How can you help in this situation?

Thank you.

Greetings,

You ask perhaps the most common question that is presented to me in a thousand different ways: “I have Peyronie’s disease, how can you help me?”

You are correct in wanting to get Peyronies treatment started early before the usual tissue changes become entrenched and more difficult to reverse; it can be done later, but is usually faster and easier to help in the early stages.

I enjoy the sense of knowing that I can assist someone like you toward recovery from Peyronie's disease, so I also feel fortunate that you found this website. In fact, maybe because it is early on a Sunday morning that I am writing this response, I will approach my reply to you in a slightly different way. You see, I have received hundreds and hundreds of emails exactly like yours – and I have answered each of them and yet I never know the best way to answer your most fundamental and sincere question.

I spend from 50-60 hours a week talking to men from around the world, answering emails, writing various articles and posts for the PDI website, and tending to the business of helping the shocked and discouraged men who have Peyronies. After doing this for a little over 10 years, the PDI website is monstrously large and loaded with unique content about all aspects of natural Peyronie’s disease treatment.

It has been estimated that if someone were to print out the PDI website it would be well over 1,500 pages of information – how to treat PD, how to get started, how to handle various questions and problems along the way, technical information and every day practical stuff. All of that free information is available for your use and education, right now, 24 hours a day.

And yet, after all that, men like you write a simple email asking, “How can you help this situation?”

With all that I have written and presented to you that you can have right now at your immediate disposal for the mere cost of clicking on your cursor button, I do not know what else I can say or do to get that information to you that I have not already done a hundred times before. All you really have to do is look and read what is in front of you.

All you have to do is spend some time reading and learning the concepts and philosophy involved in helping your body heal the Peyronie’s plaque like it should have happened in the first place. If half the men who develop Peyronie’s disease are fortunate to have their problem spontaneously and naturally heal all on its own, then there exists the possibility that your natural healing ability can be increased and strengthened if you supply a high quantity of high quality nutrients and enzymes to assist that natural recovery process that failed to occur in you and me when I developed my Peyronie’s disease many years ago.

When i developed my Peyronie's disease I worked hard to plow through a mountain of information about this crazy problem to understand what was known and not known about it; I worked hard to sort out a large amount of technical information, facts, opinions, and what I came to know was simply lazy medical thinking; I worked hard to apply the information that made sense to me; I worked hard to put together the first Alternative Medicine treatment strategy that could actually make a difference in the recovery from PD and it actually worked for me; I worked hard to understand what was going on when the Peyronie’s plaque started to get reabsorbed and disappear; and I worked hard to keep that recovery going until all the plaque disappeared and the distortion finally straightened out.

And now I am answering your question to make it easy for you, but you still must spend a little time reading the PDI website. Go to “Start Peyronie’s Treatment” that is found toward the top of the home page, and read.

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And as I always conclude when I finish a response, if you have any questions please let me know and I will be happy to assist you. TRH

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What are the ingredients and concentration (%) of the DMSO to treat Peyronie's disease?

Have a few questions about the “PMD DMSO Gel” if you don't mind.

Was curious the ingredients or concentration(%) of the DMSO (dilution)?

I had some irritation before from a 80% DMSO, but I wasn't using it for Peyronie's.

Thanks.

Greetings,

Our PMD DMSO is a special formula that was developed specifically to be used for Peyronie's disease treatment. This formulation was created with the cooperation and help of Stanley Jacobs, MD, who did the original DMSO medical research that made it so popular in the late 1950s.

The PMD DMSO is a 60% DMSO, 10% urea, 10% PABA, 10% MSM, and 10% distilled water combination. Since it contains 60% DMSO it tends to not irritate the tissue and can be used often enough to do some good for treating PD; only rare men have trouble with skin irritation and this is solved by applying it less often. As you have learned, if the concentration is too high it cannot be used at all. It does no one any good to use a 100% concentration of DMSO but then not be able to use it. Our formula allows for repeated applications and this is where the real benefits come into play. Lastly, PMD DMSO is formulated in a gel form for easier and cleaner application since it tends to stay directly where it is applied and does not run down to create a mess.

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It is strongly recommended that before applying PMD DMSO that our Unique-E vitamin E oil and Super CP Serum (copper peptides) are applied over the area of Peyronie's plaque to increase the therapeutic benefit of using DMSO.

Of course, these three therapy products are topical applications and they should be combined with various internal therapies as described throughout the PDI website. TRH

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