What evidence do you have that this Peyronie’s treatment concept is effective?

If as you say 50% of men self heal from peyronies disease, what empirical evidence do you have that any of your treatments are actually effective? Testimonials of cures are to be expected in any group of men whether they take your medication or a placebo. What evidence do you have that your medication is better than a placebo?

 

Greetings,

Thank you for your valuable and interesting question.

Empirical evidence is taken from or by way of naturalistic experience or observation, as well direct experimental procedures.  It serves to defy or support a scientific theory or a working hypothesis that is under study.

For those who have spent any time reading the PDI website, you know that I have repeatedly reported that at this time it is not possible for me to conduct research or scientific investigation as is conducted by the government, large universities, medical research hospitals or pharmaceutical companies. I do the best I can under the circumstances I work under.  I am limited to the reports and communication about success and failure I receive from men who choose to follow the PDI concept of Peyronie's treatment.  This information is provided to me on a volunteer basis by men during their self-directed treatment, so it is understood that I do not have any way to control how each plan is conducted or to verify the accuracy of the information that is received.  

When early medical research was done with natural therapies like vitamin E, or acetyl-L-carnitine, or PABA, or quercetin, on Peyronie's disease the effects were often positive.   You can read these early reports in which all of these were found to have positive effects to reduce the Peyronies plaque or reduce advancement of penile distortion.  They all seem to end with the comment that would go something like, "Further investigation should be done based on these positive outcomes to verify these results."   Of course, since there is no profit or advantage in a drug company testing a common nutrient, no further testing is ever done.  No one is interested in the results of combining natural enzymes, vitamins, minerals, and performing gentle manual stretching because these ideas represent no business opportunity.

From the information I have gathered over the last 10 years while working with men who have Peyronies, I estimate that about half of these men have had their Peyronie's disease for 18 months or less, and the other half have had their Peyronie's disease for more than 18 months (many start their PDI-based treatment with a history of Peyronie's disease of five years duration, and a few have had their problem for 10 years or more).   Based on my feedback from these men, there does not seem to be much difference in the rate or degree of improvement between these two groups, or in the types of problems or difficulties they encounter while under care.   It seems that the body is able to heal or correct a newer (18 months or less) case of PD about as easily as an older (18 months or more) case of PD.   This 18-month time reference point is important because it is rather commonly maintained that any case of PD that will spontaneously heal or self-correct will do so before the 18th month; after 18 months the PD is considered permanent.  This is the reason so many surgeons will wait until a case of Peyronie's disease has reached the 18 month mark, since at this time the condition is thought to be stable and permanent.  

When I worked to develop the treatment plan that eventually became the PDI concept of Peyronies treatment I had my PD for about 18 months.  Many men who report back to me their positive results have had their problem for 2-4-6 years or more.  All of these cases are considered permanent and stable by medical standards.  Any change or reversal of the size, shape, density or surface features of  their PD scar mass or change in their deformed or curved penis would have to be considered clinically significant.  

At this time I am not interested in conducting blind studies with placebos with men who have Peyronies.   After 10 years of work I am at a point where I still improving and expanding the PDI treatment protocol.  It would be wrong for me to conduct research in this way that would deny every man the opportunity to reverse his problem.  Keep in mind that I am not attempting to make pigs fly; the PDI concept is really not all that extraordinary or extreme.  All we are attempting to do is to increase or support the natural ability of the body to heal and repair PD that tends to occur in about 50% of the men who develop this condition.  For many men who take the time to read the information on this website the idea of natural healing makes sense.   I suppose it all comes down to the question of, "Do you think it is possible to help the body heal if you improve your nutrition and do a few common sense things that assist the process of recovery like tissue detoxification, simple stretching and increase of blood flow?"  

You are viewing this work while it is its early stages, as the men are told when they read the PDI website.   Testimonials and personal communication is what many medical ideas have developed from in the past.  You are seeing this idea at that stage of development.  I do not know if that should be a reason for condemnation of this work.  Many men who need treatment for Peyronies disease understand the basic concept of supporting the ability to heal and repair and give the process a try.  Many who do it well find good results.

I completely understand your concern and interest in evidence of treatment efficacy, and comparison to placebo response.   However, keep in mind that all the glowing praise and approval for a drug that passes through government, university, medical research hospital, or pharmaceutical company research is no guarantee of effectiveness or safety of those same drugs or procedures.  So much of the kind of proof that you ask about seems to make very little difference to the people who use those approved drugs in the real world.  So many of the drugs that pass through rigorous research tests, and perform so much better than placebos, only come to fail to get results with actual patients or are found to be dangerous because of the side-effects and dangerous complications they cause. 

Again, thank you for the opportunity to explore and discuss this question.  Perhaps in time this idea will be taken up by a large research group when I have gathered more evidence and weight of public opinion.   TRH

How many units of vitamin E should I take for my Peyronies?

Hi,

After reading much of the literature on Vitamin E treatment I find it hard to conclude how many IU’s of the vitamin one needs to take on daily basis ??

Thanks
Dave

 

Greetings Dave,

With the naturally occurring and full spectrum vitamin E that is available on the PDI website there is much less cause for concern than when the synthetic forms of vitamin E are used.  All the nasty reports of bad reactions to vitamin E involved the use of synthetic vitamin E.

It is best to keep your daily dosage down to around 1200 IU of vitamin E when used in conjunction with a larger plan of diversified therapies.   When you place your order with PDI for any therapy products you will be given complete and detailed information how to use whatever you order.  TRH

What is the difference bewteen the two vitamin E products you use for Peyronie’s disease treatment?

Hello,

I was wondering about these two products:  Vitamin E Factor 400/400 and the other is  Maxi-Gamma E.

I am probably not understanding this correctly which is why I am emailing, but they seem to both be vitamin e.   Is that correct?   If so why take both? I would be taking too much vitamin e if I take both.   If I am not correct could you explain the difference.

Thank you
Carl

 

Greetings Carl,

Yes both are vitamin E products.   But, vitamin E is not one thing; vitamin E is actually a family of eight different but related fat-soluble compounds that exist in diverse forms, all widely found in the plant kingdom. There are two basic groups of vitamin E, the tocopherol family and the tocotrienol family; each of these two forms has four subdivisions called alpha, beta, delta and gamma, for a total of eight variations or forms of vitamin E.    Different forms of vitamin E are found in different parts of a plant; the green parts of a plant contain mostly alpha tocopherol and the seed germ and bran contain mostly tocotrienols.

The product Vitamin E Factor 400/400 is very unique in the world of nutrition because it contains a large amount of all eight members of the entire vitamin E family for broad based support of this important vitamin group. 

The product Maxi-Gamma E is also unique because it primarily contains gamma tocopherol, the one member of the vitamin E family that is most responsible for soft tissue healing hence its importance to Peyronie's disease treatment.   

PDI makes both of these products available – and most men who follow a successful PDI Peyronies treatment plan will use both products  typically taking one of these in the AM and the other in the PM.

Why do you think that taking both would be too much?   Overdosing with vitamin E occurs at a relatively low dose only when synthetic vitamin E is taken.  PDI only supplies natural forms of vitamin E that are organic.  Please see this article   Peyronie's Disease Treatment and Vitamin E for a discussion about the silly vitamin E scare that is going around simply because people do not understand the story behind vitamin E.  You will understand the background of how poor research and bias maligns even a naturally occurring vitamin that is essential for health.

Unfortunately most vitamin E supplements contain only alpha-tocopherol. This information should make it all the more obvious why a Peyronies disease victim needs to carefully choose supplements that contain the complete vitamin E family of tocopherols plus tocotrienols and any that are  especially rich in gamma-tocopherol. Like all families, each member has certain strengths and abilities, requiring a variety of workers to support the necessary tissue changes needed to improve the health and resistance of tissue damaged in PD. Here is a list of the eight forms of vitamin E:

Tocopherol group

Alpha-tocopherol
Beta-tocopherol
Gamma-tocopherol
Delta-tocopherol

Tocotrienol group

Alpha-tocotrienol
Beta-tocotrienol
Gamma-tocotrienol
Delta-tocotrienol

Each of the two forms has its own area of use or activity in the body. The tocopherol forms function as strong antioxidants, with the alpha form being the most active of the four subdivisions. Vitamin E, like all antioxidants, protect at the cellular level against the effects of potentially damaging by-products of metabolism, called free radicals. A free radical is a molecule that has been involved in a chemical process in the body, and in so doing becomes unstable when it loses an electron. Free radicals can cause cell damage by attracting electrons from stable molecules in other areas in the body, thus making additional cells also unstable.

Unless they are connected to an antioxidant, highly unstable free radicals attack the polyunsaturated fatty acids of cell membranes in a chain reaction. This process of losing and gaining electrons might contribute to the development of heart disease, cancer; Alzheimer's disease, arthritis, premature aging and cataracts and even excess scar formation.

Peyronie's and vitamin E connection

The tocotrienol form of vitamin E has shown superior action in maintaining arterial health because of its ability to reduce plaque and fibrous tissue infiltration in damaged arterial walls. This same ability is suspected to result in reduction of scar and fibrous tissue buildup in other parts of the body.

Vitamin E has 75% worldwide approval as a first-line treatment of Peyronie's disease, yet its effectiveness has not been proven to scientific standards. It is the most popular of the alternative treatments used. Vitamin E is perhaps the most researched and tested of the alternative methods for treatment of PD, and yet it has not been researched or tested very much. It has been heavily researched and tested for other health conditions that have the same or similar scar and fibrous tissue formation, and it has proven its effectiveness. Use of vitamin E is based not only on the positive results it gets with Peyronie's disease, but also the positive results scored against other health conditions similar to it.

Maybe your family doctor or local urologist doesn’t recommend using vitamin E for PD, but you can now see there is a lot of science backing up this idea, and there are thousands of doctors from around the world who use it successfully. You are now aware of some of the reasons it is used as a first-line of treatment against Peyronie's disease. If you were going to use only one therapy to improve the health of your tissue and increase your chance of repairing some of the damage of PD, vitamin E should be considered as that one thing.

Using vitamin E – and therefore vitamin C – is the perhaps the most commonly recommended conservative method to assist the healing of the PD scar in traditional medical practice, as well as alternative medical practice.

I hope this information helps you understand the role of vitamin E in Peyronie's disease treatment.  TRH

Which PDI treatment plan would be beneficial to my Peyronie’s disease?

I had been having problems with pain upon erection and lumps along the shaft of my penis for several months and then I started having a lot more pain.

I went to a urologist who initially told me he couldn't find anything abnormal but during a subsequent follow-up visit he told me that I have Peyronies Disease and that the lumps were plaque formation and there wasn't much I could do about it. He advised oral Vitamin E (which I take religiously) and waiting to see if it got better without injections or Peyronie's surgery.

I had never heard of this disease so I have been researching it. I do not have any obvious outward sign like scars or any curvature but I can feel the plaque deposits and have very painful erections.  Sometimes there is pain even without erections. I don't remember having any specific injury or trauma to my penis during sex but sex definitely makes the pain worse. I am really worried that although there is no curvature now, there will be if I follow the doctor's "wait and see" plan.

I already feel a "pulling upward" sensation with erections. I would like to know which of your treatment plans would likely be most beneficial to me. The biggest problem is the pain and the lumps that seem to produce this "tugging or pulling" feeling. My first thought is to jump in with both feet into the most aggressive treatment you have but maybe that is not the correct thing to do. I would really appreciate any guidance you can give me.

Greetings,

Thank you for your question.

You must stop doing anything that causes your Peyronie's disease to be more painful.  Pain indicates that you are again stressing the deep plaque or scar tissue of your Peyronies, and this is harmful and will delay your recovery.  This does not specifically mean stopping sexual intercourse; it only implies you must determine what you  are doing during intercourse, or how you engage in intercourse, that causes physical stress upon the penile tissue and change that aspect of your technique.   This is a huge, diverse and important subject, and for this reason I suggest you should consult a book I wrote, "Peyronie's Disease and Sex."    

Taking vitamin E by itself, or taking the wrong kind of vitamin E, no matter how religiously you take it will not help your PD.  You must use the right type of vitamin E, take it at the right time and in combination with other important therapies for it to help your problem.  Please refer to the section in the PDI website about vitamin E that covers this important subject. 

Penile distortion can occur immediately in Peyronie's disease, but it can also take months or years to develop.  Further,  I have communicated with many men whose PD distortion suddenly worsened after being static for a few years.  For this reason you must not assume your problem will always look the way it looks at this time; they usually worsen over time.    

No one can tell you ahead of time which PD plan will work best for you.   Please read "Do you simply recommend the same treatment products to all Peyronies cases?"   You will then understand that all treatment must be unique and driven by specific response of your Peyronie's plaque or scar.  Lastly, it would appear that you think that the Peyronie's scar is located on surface of the shaft; it is not.     The Peyronies plaque and scar are terms for the same fibrous material that is found deep within the penis below the skin surface; in the world of PD the scar and plaque mean the same thing.  The scar or plaque are not visible from the exterior since they are internal.

 Let me know if I can help you in any way with eliminating your PD scar with Alternative Medicine.  TRH    

Information about vitamin E and Peyronie’s treatment

Dear Dr Herazy,

I am a GP in the UK.   I have a patient with Peyronies, who has been following your advice (through your publications and web site) for some time. He is very happy with your advice and his results.  He asked if I could ask you some specific questions?

He has been using vitamin E for some time, and feels it does benefit him, however given the recent data from the SELECT trial, he is concerned if he should continue, he wondered what your advice might be.   Also, he wanted to know if you had any position on the use of fish oils ( omega 6-3) and activated vit D ( cholecalciferol) in the management of PD.

I have been trying to guide him through the available data. He would have contacted you directly but asked if I would do so, partly because I suspect he feels it is more 'official' through me and partly because I understand he does not have internet access at the moment.

I'd be grateful for any advice you can offer.

I would prefer that you do not use my name when you reply to this email, for confidentiality reasons.  

Best wishes.

Dr EXXX    SXXXXX
GP
Hurley Clinic

 

Greetings Dr. SXXXXX,

Of course.   Many people have been concerned about the findings of the SELECT trial of vitamin E, although if they knew a few details of that report they would be far less concerned.    They would understand that the conclusions they cite are misguided and based on several false premises that alter the conclusions that should be drawn.

Since this important topic bears a detailed explanation that I have already answered at length, allow me to direct you to my article, "Peyronie's Disease Treatment and Vitamin E." 

In regard to omega 3, 6 and 9 oils, we have always taken the stand that they are very helpful to Peyronie's treatment, especially in the early stages to reduce and control the inflammatory process that often causes pain.  Please refer to the discussion of Omega T and the essential fatty acids.   TRH 

What do I start doing to prevent my Peyronie’s disease from getting worse?

I was just told last week that I have pd..I have some pain that is light, no curving, but my erections are weak on the left side at the base with some mild ED. What do I start doing to prevent it from getting worse?  I saw my urologist who told me to take vitamin E 1000 IU daily.  Please advise me to help it not get any worse…thanks

Larry Baldwin


Greetings Larry,

I have never seen vitamin E by itself help anyone with Peyronie's disease.  Vitamin E is a great therapy but it must be combined with a variety of other therapies to make a positive and helpful impact on a difficult problem like PD.  Besides that, you cannot just take a general or lesser grade of vitamin E and expect it to work for you;  a pharmaceutical grade is required.  PDI has two great therapeutic grades of vitamin E available on the website.

You should by reading about Peyronie's disease on the PDI website, especially starting with the page "Start Peyronie's Treatment."  

When you have a specific question about treatment of Peyronie's disease please let me know.   TRH

Will a combination of Neprinol and vitamin E be effective for my Peyronie’s disease?

Do you think that a combination of Neprinol and vitamin E will be effective in helping my Peyronie's disease?

Greetings,

There is no way to tell ahead of time if any Peyronie's treatment plan will be effective.   No matter what plan you start with, it is always a guess to know at the start of care if it will help.   The eventual treatment plan a man uses to eliminate his PD is determined by its ability to influence the PD scar.  Each person has different needs, and this prevents one treatment idea from being the solution for everyone.    It is necessary to evaluate the effectiveness of any plan by looking for changes in the size, shape, density and surface features of your scars while you following your treatment.   You can start with any type of plan you believe might help you, but it is the response of the  scar tissue that guides and determines type of therapy that is used and at what dosage.

Your question tells me you have not spent much time on the PDI website.   You really should go over the PDI home page and follow the links you will find there.  If you are interested in recovering from your PD it is a great way to get an education how Alternative Medicine can be used to increase your ability to heal and repair the Peyronie's plaque that is causing your bent penis.

Using Neprinol and vitamin E is a small combination that is far too limited to reach into the problem of Peyronie's disease.  I have never heard of anyone who used this combination and got results.   As an example, if you look at the PDI small plan you will see there are seven different ingredients in that plan – and it is called small.   I am fully aware that many men can have financial problems that limit the amount of therapy they use, yet these same men also want a Peyronie's treatment plan that gets results.

You see, it is not really what I think about using Neprinol and vitamin E that is important.   All I can tell you is that no one has ever told me that taking only these two therapies has helped his PD.    Usually, the plan must be larger to be effective.   How large does your plan have to be?   I don't know.   You have to figure that out for yourself while you are working with your problem.  I suggest you start here reading this website of the Peyronie's Disease Institute to  learn how this is done.   TRH

How long until I see any improvement with my Peyronies problem?

I'm 18 years old and I have PD. I think I had it for 2-3 years, really not sure. It curves up from my pelvic bone to the middle and curves down from the middle to tip. So it kind of looks like an arch or rainbow. It also looks really dark, I'm white Italian and it shouldn't be really dark like that.

I really don't want to go to the doctors, I asked to go to the urologist but kept getting questioned why. I came to the conclusion that I'm probably not going to go so I want to help myself.  I want to buy "Vitamin E: Unique-Oil – 1 oz pump bottle", "DMSO – PMD DMSO Gel", and "Super CP Serum".  I been using vitamin e capsule gels and using the gel inside as a moisturizer with baby oil for the past few days.

I want to know how to use the vitamin e properly for your mixture. Do I mix them all together and put it on? Do I use them one at a time? Do I have to be flaccid? Do I use after shower I get out of shower and leave on overnight? Also, how do you rub it in and for how long? Will the box definitely be "Discreet Shipping" even if I don't buy a plan and just those 3 bottles?

I live with my parents and my brothers, sister and my friends are constantly over so I don't want anyone to see the box if I don't get it first. I can just tell my mom the stuff is for my scar and my face because I used to use the capsule gels for that.

Also, how long do you think until it fixes it and how long until I see any improvement? I want to get with a girl and embarrassed to get close to her because of it.

Thank you

 

Greetings young man,

You need to get over your embarrassment and seek out a medical opinion and have your condition formally diagnosed. 

Why are you mixing vitamin E with baby oil?   Please use the products as instructed when you receive your order from PDI; all products come with complete and correct instructions for use to treat Peyronie's disease. 

Using only DMSO, vitamin E oil (Unique E) and copper peptides  (Super CP Serum) is a very limited and lopsided approach to good Alternative Medicine treatment; good treatment usually demands both internal (PABA, vitamin C and E, systemic enzymes), as well as external therapies.

Yes, all products received from PDI come discreetly boxed, with no outside identification that would embarrass you.  However, inside the box we freely identify and discuss Peyronies disease.

There is no way ahead of time to tell you how long it will take to recover from your PD, or even if you will do so.  It is a very difficult problem to remedy. Get your parents involved in your treatment so you are not doing this alone and you are able to mount the kind of aggressive treatment that is usually most effective. TRH 

What is a good vitamin E for Peyronie’s treatment?

I was diagnosed with Peyronie's several years ago and my doc told me to take Vitamin E. In a few weeks, the symptoms cleared up. My problem is that I've developed PD again, have seen another urologist who also suggested Vitamin E. The PD seems much worse this time around. My question..if I choose to simply take Vitamin E, can you recommend the exact(and very best) brand, dosage, etc. I'm still sexually active, but it is affecting my sex life and is very stressful. Any help you might offer would be greatly appreciated. Also, I have read/researched at great lengths on your site and may return if you cannot offer a possible solution based upon the info I've provided. Thank you very much, Bobby

Greetings Bobby,

Sorry to hear of your Peyronie's problem.

Vitamin E is one of the cornerstone Alternative Medicine therapies recommended by PDI.  You can read about using vitamin E for Peyronie's treatment on the PDI website.  However, it is not all that is usually needed to recover from this problem.  So often it is required that a man assemble a group of therapies to take all at the same time to finally increase the immune response of the body against this problem.

PDI has a shopping cart from which you can order a great vitamin E product that we have used for over ten years.   Feel free to contact me if you have additional questions about helping yourself with natural therapy.   TRH 

Do you think using vitamin E by itself will help my Peyronie’s disease?

Greetings Doctor,

My urologist recommended taking 400 I U of vitamin E daily when he first told me I had Peyronie's disease, although he was not too specific about the quality or type of vitamin E I should use, or anything else for that matter.  Before he ran out the door he did not say what the next step would be if that did not help me, but he did stress that I should return in six months for another visit.

Thank you for the helpful information about vitamin E on your Peyronies website.  At least I know now how to do it, and I will get mine from you so I know I will be taking the best vitamin E for this purpose.  I will try my doctors recommendation of just using vitamin E by itself and keep my fingers crossed.  Do you think using vitamin E  by itself will help my Peyronie's disease?   Paul

Greetings Paul,

No, I do not.  Vitamin E for Peyronies treatment is great, but it needs a lot of support from other kinds of therapy to get the job done.  And finger crossing has nothing to do with successfully treating your Peyronie's disease.  

Success is based on hard work, determination, dedication and focus to a broad based Alt Med plan that will increase your body's ability to heal and repair the Peyronie's scar.  I suggest you do all you can during these next six months to learn about your PD and the process of natural correction. The PDI treatment protocol has a high degree of success when it is done correctly.  The problem is that many men try to bastardize the PDI treatment protocol to save a few bucks, or is too lazy to do what is required, or is always looking for the easy way out.  I trust you are not that way.

Go ahead and follow your urologist's idea of using vitamin E as a solo therapy.  I have never heard of anyone who has been successful with this idea – and neither has your urologist.  He is just telling you to do that because that is what the text books tell him to say and he cannot get into trouble for repeating what is accepted current medical thinking. What is probably on his mind is that at your next office visit in six months he will be able to follow the same current medical thinking and tell you that you need Peyronie's surgery because the vitamin E did not work. They have a great thing going for themselves. 

I suggest you spend a little time on the PDI website educating yourself about the non-drug and non-surgical treatment of Peyronie's disease.  If you need any more information please let me know.  TRH