What is the difference between DMSO in gel and liquid form?

Online the PDI site says your DMSO LIQUID is more effective than the GEL. I fear the topicals I use won't penetrate as deeply if i were to use the liquid? How is effectiveness different?  Thank you.


Both the gel and liquid format are effective in their own way, depending on what you want to accomplish. Read DMSO in Peyronie's Therapy.

We have determined that the DMSO liquid penetrates faster than the gel, but not only a little faster.   And we have determined that the DMSO gel penetrates deeper and carries more therapy agents with it.  For this important reason in 2009 PDI converted both the Dusa Sal DMSO (Dupuytren contracture) and PMD DMSO (Peyronie's disease) products to being made with a gel base.  It makes sense to sacrifice a little speed of penetration to gain depth and amount of therapy delivered to the tissue involved.   TRH

What is the success rate of PDI Peyronies treatment approach?

I am curious, what is the success rate of your Peyronies treatment approach? John from Australia

Greetings John,

You ask about PDI Peyronie's disease treatment results. All day long I send emails to men from around the world – like yourself – who do not have to report back to me, and over whom I have no control as to how, if, and when they use their various therapies.

I can only tell you this directly about the treatment results I have heard about from men over the years: I receive about 12-15 emails or telephone conversations reporting improvement in scar size, shape or density, or favorable change in penis curvature, or improvement of sexual function, for every one email or telephone call I receive complaining of no progress concerning the above. Considering that people tend to complain more than they compliment, I interpret this 12:1 ratio in a very favorable way.  But to give you percentages of natural Peyronies treatment improvement, I cannot report that to you at this time. Perhaps some time in the future when we are able to do formal research.

PDI is not yet conducting controlled studies, so I have no way of knowing how any of this is being used. And of course how these products are used determines the results that are earned. I get back bits and pieces of information from men about their treatment results. My feedback is limited in response to the large amount of information I put out to the PD community.

There is no guarantee that you or anyone else will use any of these products as I suggest that you use them. Actually, after doing this work since 2002 I find that few people start out using their Peyronie's treatment plan in the correct way.  You know how people can be. I can only hope that the suggestions I make are given fair consideration and application is made in the correct way. As a result, I do not receive with any regularity reports from men about their treatment results.

All I can tell you is that the more that a person does to knock that scar out of the tissue, the greater the synergistic effect and the greater the likelihood for success. You either understand the concept of synergy or you don’t. It is the reason that MDs have so much trouble with patients when they start putting them on more than one drug – when combined, the synergistic effect of multiple drugs begins to magnify, often causing drug reactions that most people have come to be concerned about. In the area of Alternative Medicine the results tend to be beneficial.

I notice from your records that you have only ordered Scar-X from PDI, and nothing else to treat your PD.   It is a good product we have used with success over many years. However, since you order only Scar-X you are using this product in a way it is not intended to be used.   You are a good example of what I mentioned earlier.  You are not following the suggestions of PDI and yet you will judge PDI results after not following our suggestions.   It is your decision; I can only advise you along the way and you will decide how you wish to proceed.  TRH

What is my opinion of prescription drug injection?

What is the Dr's opinion on using the prescription Edex injected with a syringe? 

Bryant from Ohio


Greetings Bryant, 

You ask for my opinion about Edex injections.  I will not comment on the drug, because that is the decision of your treating doctor.  But I will make a few observations about injections in general and how they could further injure the tunica albuginea.

Anytime you inject ANYTHING – even sterile water – into the penis and directly or indirectly contact the delicate tunica albuginea, you are taking a serious risk of making your Peyronie's disease worse. This could either occur just from the simple act of piercing the tissue of the tunica albuginea, or the placement of a concentrated chemical that is foreign to that tissue, or both.

I have communicated with many, many men whose Peyronie's disease started or was made worse from penile injections of a variety of substances.

If your problem is PD, why are you taking an ED medication? Some MDs prescribe Viagra, Edex, etc to their PD patients in the belief that this increases the local circulation which in turn is beneficial to PD.

What if you could take a drug that would enable you to lift a ton of weight above your head and keep it there for an hour? Nice trick, very impressive, but your body is not built to take that kind of pressure. It would cause great damage to internal organs, your spine, your blood vessels, all major joints, etc. Simply put, “It just ain’t natural.” Same with Viagra, Levitra or Cialis. The increased pressure created by these medications can be very damaging to the delicate tunica albuginea, and can result in or worsen a case of PD. What would happen to your car tires if you happened to over-inflate them with 100 pounds of air pressure, even though they were built to take just 40 pounds of pressure. You would be running the risk of damage to the internal structure of tire, wouldn’t you? Of course.

The same thing can happen if the penis is over-inflated and then given a “rough ride.” This is where the problems start, and this is what I wanted to bring to your attention. It is very likely that the MDs who prescribe these medications to men with PD will not agree with this thinking. MDs tend to favor a chemical “fix” even if it is temporary, so you would tend to expect a prejudice from an MD to use drugs to solve most problems.

A penis that is predisposed to PD in the first place cannot tolerate the kind of stress that these erections drugs create.  If you think independently and logically about what happens when these drugs are used, you should have no trouble understanding how this could work against you.  That is just the way I see it and I feel compelled to share this rationale with you. Use of Viagra and other related meds like it could easily be worsening the very problem you are attempting to heal. Something to think about.  TRH

What is the daily dose recommended for Neprinol?

What is the daily dose recommended for Neprinol? Thank you.

Bill C.

Greetings Bill C.,

There are several things to say about dosage in general for Peyronie treatment, that applies to Neprinol dosage in particular

1.  The starting dosage for any therapy is often the one that is listed on the label for that product.  This standard starting point is used to see if the dosage recommended by the product manufacturer can bring about a favorable change in the size, shape, density and surface features of your scar.  Often it cannot.

2.  The ongoing treatment dosage that eventually proves to reduce the original size and shape of the scar, or soften the density, or alter the surface features of a Peyronies plaque will very often be higher than what is suggested on the label of each product. 

3.  No matter which therapy product you use, it must be taken in a safe and reasonable dosage.  All of this information is available to you in the treatment section of the PDI website.  Please read that information and adhere to it.  

4.  Dosage for any ONE therapy product that is actually going to help your Peyronie's disease is not easy to determine because you will be taking MANY therapy products at the same time.  You are juggling many balls at once and this requires some patience and the ability to keep good notes about what you are doing. 

Of course, if you are taking five different internal therapies (vitamin E, vitamin C, Neprinol, Acetyl-L-carnitine and PABA) each one must be individually determined.  An important part of your therapy plan are the external therapies you are using (Genesen Acutouch pens, gentle manual stretching, DMSO, etc.) While you do all the internal and external therapies that make up your total therapy plan you must monitor the size, shape, density and surface quality of your scar(s) to note at what dosage level changes begin in the scar material.  It is as simple – and difficult – as that.

5. No clear and specific treatment dosage numbers are offered to you since everyone uses different internal and external therapies, in addition to doing them in different ways.  In this sense, since each man is different, and each man follows a different plan, each man must determine what he must do to improve his scar behavior.

The procedure to determine scar size, shape, density and surface quality is explained in great detail in “Peyronie’s Disease Handbook.” The correct dosage of any therapy product is not determined from a chart. The chart that you receive with your first order only tells you the average range of what most men are doing. Your dosage should be what you need to take daily to cause changes in your PD scar. The dosage for you is what you learn works for you. I cannot tell you what you need to take. You have to determine that by your observation of the dose that makes the scar size, shape, density, and surface quality change. This vital information will guide your use of all the therapy products; it is the measurement that tells you if your plan is working or not. All of this is explained in great detail in “Peyronie’s Disease Handbook.”

What is the average age for onset of Peyronies?

Greetings Dr. Ted, 

Thanks again for all the information you have provided in the past. My curve has gone from 60 degrees to less than 10 degrees.  I can't believe all this change in just 13 weeks after only getting worse for the last three years.

One more question that I have is about my age when my PD started.  I am 36 now and I got PD when I was 33.  According to most sites you read it states that occurrence typically is after age 55+, and some even say 40+.   Although I am sure there is great variation, does 33 seem young or typical given your experience?

Thanks again,


Greetings Gary,

No, 33 is not especially young to develop Peyronie's disease.  I, unfortunately, communicate with many men your age and even younger who have PD.  Last week I was involved in a lengthy discussion with a young man of 18 years who has had a diagnosed case of PD for almost two years. It does happen.

Age is less of a factor in Peyronie's disease than people would like to think, and the numbers are not absolute.  Just as you have stated that many sources report that PD usually occurs in men 40+ or 55+ or whatever age you might read, that does not mean there is a wall protecting you for the next few years if you are 37 years old.  While it is true Peyronies disease is a problem of older men, you youngsters can develop it also.  I would not put too much emphasis on that entire subject of age and PD.

The real question is now that you know you have PD, what are you going to do about it?  Let me know if I can help you tweak your plan a bit more to increase the rate of your improvement.  TRH

What is the best combination of products for treatment of Peyronies?

You may not be the one to ask but what is the best combination for treatment of Peyronies?  I have read and seen so much, my head is spinning. Thank you. Sonny

Greetings Sonny,

Probably a good place to start is by looking at the structure and diversity of the three Peyronies treatment plans (small, medium and large) that are shown and described at the top of the page of the treatment page on the PDI website. 

These different plans were put together so you can see how a balanced and diversified plan looks, and to make it easy for men to purchase a plan as a simple starting point for natural Peyronie's treatment.

Ultimately the best plan is the one that reduces the size, shape and density of your Peyronie's plaque.  This is determined over time by monitoring your PD scars while you are self-administering any plan you put together for yourself or have selected from the three PDI offers you.

To get to the point of your question about the "best": there is no best for everyone. You must search it out based on what works for you.

I think people come to the PDI looking for the "best" PD treatment in the same way they go to their doctor looking for the best drug to reduce their high blood pressure or the best salve for their rash.  In the PDI method of treatment we realize their is no one single Peyronie's treatment; we realize a combination of treatments are used at the same time to encourage and support the body to heal the PD plaque.  Further, we realize that this combination is different for everyone.   So each man starts out using the plan that he thinks might help him, and is prepared to modify it later if it does not make the necessary changes in his scar tissue.  This is why it is so difficult to answer the question "What is the best Peyronie's treatment?"   Each person must work that out individually.  I can help you with that process.  TRH